OR56A4
Identifiers
AliasesOR56A4, OR11-49, olfactory receptor family 56 subfamily A member 4
External IDsMGI: 3030518 HomoloGene: 133596 GeneCards: OR56A4
Orthologs
SpeciesHumanMouse
Entrez

120793

244187

Ensembl

ENSG00000183389

ENSMUSG00000047225

UniProt

Q8NGH8

Q7TRN8

RefSeq (mRNA)

NM_001005179

NM_207249

RefSeq (protein)

NP_001005179

NP_997132

Location (UCSC)Chr 11: 6 – 6.01 MbChr 7: 104.8 – 104.81 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Olfactory receptor 56A4 is a protein that in humans is encoded by the OR56A4 gene.[5]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[5]

Ligands

See also

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000183389 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000047225 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. 1 2 "Entrez Gene: OR56A4 olfactory receptor, family 56, subfamily A, member 4".
  6. ↑ Adipietro KA, Mainland JD, Matsunami H (2012). "Functional evolution of mammalian odorant receptors". PLOS Genetics. 8 (7): e1002821. doi:10.1371/journal.pgen.1002821. PMC 3395614. PMID 22807691.
  7. ↑ Mainland JD, Keller A, Li YR, Zhou T, Trimmer C, Snyder LL, et al. (January 2014). "The missense of smell: functional variability in the human odorant receptor repertoire". Nature Neuroscience. 17 (1): 114–20. doi:10.1038/nn.3598. PMC 3990440. PMID 24316890.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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