Small nucleolar RNA TBR5
Predicted secondary structure and sequence conservation of snoTBR5
Identifiers
SymbolsnoTBR5
RfamRF00292
Other data
RNA typeGene; snRNA; snoRNA; CD-box
Domain(s)Eukaryota
GOGO:0006396 GO:0005730
SOSO:0000593
PDB structuresPDBe

In molecular biology, TBR5 is a member of the C/D class of snoRNA which contain the C (UGAUGA) and D (CUGA) box motifs. Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs.[1][2]

Together with TBR7 and TBR17 it is a part of a tandemly repeated snoRNA gene cluster, located within the spliced leader RNA (SLA).[3] The cluster genes are produced as polycistronic RNA.[4]

See also

Small nucleolar RNA TBR2

References

  1. ↑ Galardi S, Fatica A, Bachi A, Scaloni A, Presutti C, Bozzoni I (October 2002). "Purified box C/D snoRNPs are able to reproduce site-specific 2'-O-methylation of target RNA in vitro". Molecular and Cellular Biology. 22 (19): 6663–8. doi:10.1128/MCB.22.19.6663-6668.2002. PMC 134041. PMID 12215523.
  2. ↑ Dunbar DA, Wormsley S, Lowe TM, Baserga SJ (May 2000). "Fibrillarin-associated box C/D small nucleolar RNAs in Trypanosoma brucei. Sequence conservation and implications for 2'-O-ribose methylation of rRNA". The Journal of Biological Chemistry. 275 (19): 14767–76. doi:10.1074/jbc.M001180200. PMID 10747997.
  3. ↑ Roberts TG, Sturm NR, Yee BK, Yu MC, Hartshorne T, Agabian N, Campbell DA (August 1998). "Three small nucleolar RNAs identified from the spliced leader-associated RNA locus in kinetoplastid protozoans". Molecular and Cellular Biology. 18 (8): 4409–17. doi:10.1128/mcb.18.8.4409. PMC 109026. PMID 9671450.
  4. ↑ Dunbar DA, Chen AA, Wormsley S, Baserga SJ (August 2000). "The genes for small nucleolar RNAs in Trypanosoma brucei are organized in clusters and are transcribed as a polycistronic RNA". Nucleic Acids Research. 28 (15): 2855–61. doi:10.1093/nar/28.15.2855. PMC 102681. PMID 10908346.
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