Small nucleolar RNA SNORA30/SNORA37 family
Predicted secondary structure and sequence conservation of SNORA30
Identifiers
SymbolSNORA30
Alt. SymbolssnoACA30
RfamRF00415
Other data
RNA typeGene; snRNA; snoRNA; H/ACA-box
Domain(s)Eukaryota
GOGO:0006396 GO:0005730
SOSO:0000594
PDB structuresPDBe

In molecular biology, SNORA30 (also known as ACA30) is a non-coding RNA (ncRNA) molecule which functions in the biogenesis (modification) of other small nuclear RNAs (snRNAs). This type of modifying RNA is located in the nucleolus of eukaryotic cells. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a 'guide RNA' as it 'guides' the modification process.

ACA30 was originally cloned from HeLa cells[1] and belongs to the H/ACA box class of snoRNAs based on its structure and the proteins it is associated with. snoRNA ACA30 is predicted to guide the pseudouridylation of U4643 of 28S ribosomal RNA (rRNA). Pseudouridylation is the (isomerisation of the nucleoside uridine) to the different isomeric form pseudouridine(Ψ).

This snoRNA is related to other snoRNAs identified in human (ACA37)[1] and mouse (MBI-26).[2]

References

  1. 1 2 Kiss AM, Jády BE, Bertrand E, Kiss T (July 2004). "Human box H/ACA pseudouridylation guide RNA machinery". Molecular and Cellular Biology. 24 (13): 5797–807. doi:10.1128/MCB.24.13.5797-5807.2004. PMC 480876. PMID 15199136.
  2. ↑ Hüttenhofer A, Kiefmann M, Meier-Ewert S, O'Brien J, Lehrach H, Bachellerie JP, Brosius J (June 2001). "RNomics: an experimental approach that identifies 201 candidates for novel, small, non-messenger RNAs in mouse". The EMBO Journal. 20 (11): 2943–53. doi:10.1093/emboj/20.11.2943. PMC 125495. PMID 11387227.
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