Große or Grosse is a German surname. Notable people with the surname include:
- Ben Grosse, American record producer and mixer
- Demetrius Grosse (born 1981), American actor and producer
- Hans-Werner Grosse (1922–2021), German bomber pilot
- Heinz-Josef Große (1947–1982), East German construction worker
- Julius Grosse (1828–1902), German poet
- Katharina Grosse (born 1961), German visual artist
- Maurice Grosse (1919–2006), British paranormal investigator
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