Grothe is a surname that may refer to:
- D. J. Grothe (born 1973), American writer, public speaker and President of the James Randi Educational Foundation
- Eric Grothe Jr. (born 1980), Australian former rugby league footballer
- Eric Grothe Sr. (born 1960), Australian former rugby league footballer, father of Eric Grothe Jr.
- Luma Grothe (born 1993/94), Brazilian fashion model
- Matt Grothe (born 1986), American former football quarterback
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