RACK1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4AOW, 4UG0, 4V6X, 5A2Q, 5AJ0, 5FLX
Identifiers
Aliases	RACK1, Gnb2-rs1, H12.3, HLC-7, PIG21, GNB2L1, receptor for activated C kinase 1
External IDs	OMIM: 176981 MGI: 101849 HomoloGene: 4446 GeneCards: RACK1
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q35.3 Start 181,236,897 bp[1] End 181,248,096 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 B1.2 Start 48,691,159 bp[2] End 48,697,261 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pericardium superior surface of tongue body of tongue vena cava nipple saphenous vein trachea lower lobe of lung cerebellar vermis thymus Top expressed in bone marrow ovary ganglionic eminence spleen uterus zone of skin placenta morula thymus yolk sac More reference expression data BioGPS n/a
Gene ontology Molecular function protein homodimerization activity receptor tyrosine kinase binding SH2 domain binding signaling adaptor activity protein tyrosine kinase inhibitor activity protein binding enzyme binding cysteine-type endopeptidase activator activity involved in apoptotic process molecular adaptor activity protein phosphatase binding signaling receptor binding ion channel inhibitor activity RNA binding cadherin binding ribosome binding protein kinase C binding cyclin binding Cellular component cytoplasm cell body perikaryon cell projection membrane plasma membrane neuronal cell body dendrite midbody mitochondrion perinuclear region of cytoplasm neuron projection phagocytic cup extracellular exosome nucleus IRE1-RACK1-PP2A complex nucleoplasm cytosol ribosome small ribosomal subunit cytosolic small ribosomal subunit Biological process positive regulation of protein homooligomerization positive regulation of Golgi to plasma membrane protein transport negative regulation of protein kinase B signaling positive regulation of protein phosphorylation positive regulation of ceramide biosynthetic process regulation of cell division negative regulation of phagocytosis positive regulation of gastrulation rhythmic process positive regulation of cell migration negative regulation of endoplasmic reticulum unfolded protein response cellular response to growth factor stimulus negative regulation of Wnt signaling pathway regulation of tumor necrosis factor-mediated signaling pathway negative regulation of gene expression regulation of cell cycle regulation of protein localization multicellular organism development positive regulation of GTPase activity negative regulation of hydrogen peroxide-induced neuron death positive regulation of mitochondrial depolarization gastrulation negative regulation of cell growth negative regulation of peptidyl-serine phosphorylation positive regulation of apoptotic process cell cycle regulation of growth viral process regulation of establishment of cell polarity activation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of intrinsic apoptotic signaling pathway regulation of translation positive regulation of proteasomal ubiquitin-dependent protein catabolic process cellular response to glucose stimulus positive regulation of cyclic-nucleotide phosphodiesterase activity apoptotic process negative regulation of protein tyrosine kinase activity protein biosynthesis pigmentation protein ubiquitination rescue of stalled ribosome negative regulation of translation regulation of protein localization to plasma membrane Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10399 14694 Ensembl ENSG00000204628 ENSMUSG00000020372 UniProt P63244 P68040 RefSeq (mRNA) NM_006098 NM_008143 RefSeq (protein) NP_006089 NP_032169 Location (UCSC) Chr 5: 181.24 – 181.25 Mb Chr 11: 48.69 – 48.7 Mb PubMed search [3] [4]
Wikidata
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Receptor for activated C kinase 1 (RACK1), also known as guanine nucleotide-binding protein subunit beta-2-like 1 (GNB2L1), is a 35 kDa protein that in humans is encoded by the RACK1 gene.^[5][6]

Function

RACK1 was originally isolated and identified as an intracellular protein receptor for protein kinase C, noting the significant homology to the beta subunit of heterotrimeric G proteins.^[5] Later studies established RACK1, and its yeast homolog Asc1, as a core ribosomal protein of the eukaryotic small (40S) ribosomal subunit.^[7][8][9] Much of the function of Asc1/RACK1 appears to result from its position on the 'head' of the 40S ribosomal subunit.^[10] Asc1/RACK1 participates in several aspects of eukaryotic translation and ribosome quality control, including IRES-mediated translation,^[11] non-stop decay,^[12] non-functional 18S ribosomal RNA decay,^[13] and frameshifting.^[14]

Interactions

RACK1 is positioned at the solvent-exposed surface of the 40S ribosomal subunit, where it is held in place through contacts with both the 18S rRNA and other ribosomal proteins, including uS3, uS9, and eS17. Additionally, RACK1 has been shown to interact with:

See also

• Eukaryotic small ribosomal subunit (40S)
• Protein kinase C
• Heterotrimeric G protein

References

Further reading