40S ribosomal protein S9

RPS9
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4UG0, 4V6X, 5A2Q, 5AJ0, 4KZY, 3J7R, 4D61, 4KZX, 4D5L, 5FLX, 4UJD, 3J7P, 4KZZ, 4UJE, 4UJC
Identifiers
Aliases	RPS9, S9, ribosomal protein S9
External IDs	OMIM: 603631 MGI: 1924096 HomoloGene: 68145 GeneCards: RPS9
Gene location (Human)
Chr.	Chromosome 19 (human)
End	54,249,003 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	3,709,896 bp
RNA expression pattern
	Top expressed in
	monocyte; ; right uterine tube; ; skin of abdomen; ; canal of the cervix; ; lymph node; ; appendix; ; gallbladder; ; right lobe of thyroid gland; ; ganglionic eminence; ; prostate;
	Top expressed in
	medial ganglionic eminence; ; thymus; ; maxillary prominence; ; lip; ; spleen; ; abdominal wall; ; skin of abdomen; ; molar; ; calvaria; ; lymph node;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	rRNA binding; structural constituent of ribosome; translation regulator activity; protein binding; RNA binding;
Cellular component	cytoplasm; cytosol; ribosome; membrane; focal adhesion; intracellular anatomical structure; nucleolus; small ribosomal subunit; extracellular exosome; nucleus; nucleoplasm; cytosolic small ribosomal subunit; synapse; ribonucleoprotein complex;
Biological process	positive regulation of translational fidelity; viral transcription; SRP-dependent cotranslational protein targeting to membrane; positive regulation of cell population proliferation; translational initiation; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; protein biosynthesis; rRNA processing;
	Sources:Amigo / QuickGO
Orthologs
	6203
	76846
ENSG00000274646; ENSG00000277359; ENSG00000274950; ENSG00000274626; ENSG00000275323;
	ENSG00000278270; ENSG00000278081; ENSG00000274005; ENSG00000277079; ENSG00000170889
	ENSMUSG00000006333
	P46781
	Q6ZWN5
NM_001013; NM_001321701; NM_001321702; NM_001321704; NM_001321705;
	NM_001321706
	NM_029767
NP_001004; NP_001308630; NP_001308631; NP_001308633; NP_001308634;
	NP_001308635
	NP_084043
	Wikidata
View/Edit Human	View/Edit Mouse

40S ribosomal protein S9 is a protein that in humans is encoded by the RPS9 gene.^[5]^[6]^[7]

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S4P family of ribosomal proteins. It is located in the cytoplasm. Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. As is typical for genes encoding ribosomal proteins, multiple processed pseudogenes derived from this gene are dispersed through the genome.^[7]

References

1 2 3 ENSG00000277359, ENSG00000274950, ENSG00000274626, ENSG00000275323, ENSG00000278270, ENSG00000278081, ENSG00000274005, ENSG00000277079, ENSG00000170889 GRCh38: Ensembl release 89: ENSG00000274646, ENSG00000277359, ENSG00000274950, ENSG00000274626, ENSG00000275323, ENSG00000278270, ENSG00000278081, ENSG00000274005, ENSG00000277079, ENSG00000170889 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000006333 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Frigerio JM, Dagorn JC, Iovanna JL (Jul 1995). "Cloning, sequencing and expression of the L5, L21, L27a, L28, S5, S9, S10 and S29 human ribosomal protein mRNAs". Biochim Biophys Acta. 1262 (1): 64–8. doi:10.1016/0167-4781(95)00045-i. PMID 7772601.
↑ Kenmochi N, Kawaguchi T, Rozen S, Davis E, Goodman N, Hudson TJ, Tanaka T, Page DC (Aug 1998). "A map of 75 human ribosomal protein genes". Genome Res. 8 (5): 509–23. doi:10.1101/gr.8.5.509. PMID 9582194.
1 2 "Entrez Gene: RPS9 ribosomal protein S9".

Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins". Biochem. Cell Biol. 73 (11–12): 933–47. doi:10.1139/o95-101. PMID 8722009.
Mundus DA, Bulygin KN, Yamkovoy VI, et al. (1993). "Structural arrangement of the codon-anticodon interaction area in human placenta ribosomes. Affinity labelling of the 40S subunits by derivatives of oligoribonucleotides containing the AUG codon". Biochim. Biophys. Acta. 1173 (3): 273–82. doi:10.1016/0167-4781(93)90124-v. PMID 8318536.
Vladimirov SN, Ivanov AV, Karpova GG, et al. (1996). "Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry". Eur. J. Biochem. 239 (1): 144–9. doi:10.1111/j.1432-1033.1996.0144u.x. PMID 8706699.
Yu Z, Ford BN, Glickman BW (2000). "Identification of genes responsive to BPDE treatment in HeLa cells using cDNA expression assays". Environ. Mol. Mutagen. 36 (3): 201–5. doi:10.1002/1098-2280(2000)36:3<201::AID-EM3>3.0.CO;2-1. PMID 11044901. S2CID 19391792.
Bortoluzzi S, d'Alessi F, Romualdi C, Danieli GA (2002). "Differential expression of genes coding for ribosomal proteins in different human tissues". Bioinformatics. 17 (12): 1152–7. doi:10.1093/bioinformatics/17.12.1152. PMID 11751223.
Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298. S2CID 14132033.
Yoshihama M, Uechi T, Asakawa S, et al. (2002). "The human ribosomal protein genes: sequencing and comparative analysis of 73 genes". Genome Res. 12 (3): 379–90. doi:10.1101/gr.214202. PMC 155282. PMID 11875025.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Dubois T, Zemlickova E, Howell S, Aitken A (2003). "Centaurin-alpha 1 associates in vitro and in vivo with nucleolin". Biochem. Biophys. Res. Commun. 301 (2): 502–8. doi:10.1016/S0006-291X(02)03010-3. PMID 12565890.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
Yu Y, Ji H, Doudna JA, Leary JA (2005). "Mass spectrometric analysis of the human 40S ribosomal subunit: native and HCV IRES-bound complexes". Protein Sci. 14 (6): 1438–46. doi:10.1110/ps.041293005. PMC 2253395. PMID 15883184.
Tu LC, Yan X, Hood L, Lin B (2007). "Proteomics analysis of the interactome of N-myc downstream regulated gene 1 and its interactions with the androgen response program in prostate cancer cells". Mol. Cell. Proteomics. 6 (4): 575–88. doi:10.1074/mcp.M600249-MCP200. PMID 17220478.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

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[refGRCh38Ensembl-1] 1 2 3 ENSG00000277359, ENSG00000274950, ENSG00000274626, ENSG00000275323, ENSG00000278270, ENSG00000278081, ENSG00000274005, ENSG00000277079, ENSG00000170889 GRCh38: Ensembl release 89: ENSG00000274646, ENSG00000277359, ENSG00000274950, ENSG00000274626, ENSG00000275323, ENSG00000278270, ENSG00000278081, ENSG00000274005, ENSG00000277079, ENSG00000170889 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000006333 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7772601-5] Frigerio JM, Dagorn JC, Iovanna JL (Jul 1995). "Cloning, sequencing and expression of the L5, L21, L27a, L28, S5, S9, S10 and S29 human ribosomal protein mRNAs". Biochim Biophys Acta. 1262 (1): 64–8. doi:10.1016/0167-4781(95)00045-i. PMID 7772601.

[pmid9582194-6] Kenmochi N, Kawaguchi T, Rozen S, Davis E, Goodman N, Hudson TJ, Tanaka T, Page DC (Aug 1998). "A map of 75 human ribosomal protein genes". Genome Res. 8 (5): 509–23. doi:10.1101/gr.8.5.509. PMID 9582194.

[entrez-7] 1 2 "Entrez Gene: RPS9 ribosomal protein S9".

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[5]

[6]

[7]

References

Further reading