Nomegestrol acetate/estradiol
Estradiol (top) and
nomegestrol acetate (bottom)
Combination of
Nomegestrol acetateProgestogen
EstradiolEstrogen
Clinical data
Trade namesZoely
Other namesNOMAC-E2, NOMAC/E2, MK-8175A
AHFS/Drugs.comUK Drug Information
Routes of
administration		By mouth
Drug classEstrogen; Progestogen
ATC code
Legal status
Legal status
  • UK: POM (Prescription only)[1]
  • EU: Rx-only[2]
Identifiers
CAS Number
PubChem CID
KEGG

Nomegestrol acetate/estradiol (NOMAC-E2), sold under the brand names Naemis and Zoely among others, is a fixed-dose combination medication of nomegestrol acetate, a progestogen, and estradiol, an estrogen, which is used in menopausal hormone therapy and as a birth control pill to prevent pregnancy in women.[3] It is taken by mouth.

Research

Estradiol-containing birth control pills like NOMAC-E2 may have a lower risk of venous thromboembolism than birth control pills containing ethinylestradiol.[4] This is being studied in the case of NOMAC-E2.[4][5]

See also

References

  1. ↑ "Zoely 2.5 mg/1.5 mg film-coated tablets - Summary of Product Characteristics (SmPC)". (emc). 20 July 2020. Retrieved 9 June 2021.
  2. ↑ "Zoely EPAR". European Medicines Agency (EMA). 17 September 2018. Retrieved 9 June 2021.
  3. ↑ Yang LP, Plosker GL (October 2012). "Nomegestrol acetate/estradiol: in oral contraception". Drugs. 72 (14): 1917–28. doi:10.2165/11208180-000000000-00000. PMID 22950535. S2CID 44335732.
  4. 1 2 Douxfils J, Morimont L, Bouvy C (October 2020). "Oral Contraceptives and Venous Thromboembolism: Focus on Testing that May Enable Prediction and Assessment of the Risk". Semin Thromb Hemost. 46 (8): 872–886. doi:10.1055/s-0040-1714140. PMID 33080636. S2CID 224821517.
  5. ↑ "Results from large-scale real-world safety study for oral combination contraception pill, Zoely (NOMAC-E2), submitted to European Medicines Agency". Theramex (Press release). 27 April 2021. Retrieved 9 June 2021.


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