Binding profile

6-Fluoro-DMT possess affinity for the 5-HT_1A (392.6 nM), 5-HT_1B (217.7 nM), 5-HT_1D (55.4 nM), 5-HT_1E (460.8 nM), 5-HT_2A (866 nM), 5-HT_2B (29.8 nM), 5-HT_2C (674.2 nM), 5-HT_5A (960.5 nM), 5-HT₆ (25.6 nM), 5-HT₇ (40.8 nM), D₁ (547.3 nM), D₂ (610.4 nM), D₃ (866.8 nM), D₄ (1,454 nM), D₅ (6,291 nM), α_1A-adrenergic (173.3 nM), α_2B-adrenergic (295.5 nM), α_2C-adrenergic (148.8 nM), H₁ (46.6 nM), H₂ (925.4 nM), I₁ (898.4 nM), ₁ (6,892 nM), and ₂ (7,128 nM) receptors, as well as the SERT (144.6 nM).^[1] It has low/negligible (> 10,000 nM) affinity for the 5-HT₃, α_1B-adrenergic, α_2A-adrenergic, β₁-adrenergic, β₂-adrenergic, H₃, H₄, and M₁-M₅ receptors, as well as the DAT and NET.^[1] It has not been screened at 5-HT_1F, 5-HT₄, α_1D-adrenergic, β₃-adrenergic, or VMAT₁/VMAT₂.