Vulpius is a surname, derived from Latin vulpes, "fox". Notable people with the surname include:
- Christian August Vulpius (1762–1827), German novelist and dramatist
- Christiane Vulpius (1765–1816), wife of Johann Wolfgang Goethe, sister of Christian August Vulpius
- Johann Samuel Vulpius (1760–1846), German botanist
- Melchior Vulpius (c. 1570–1615), German singer and composer
- Paul Vulpius (1880–1957), German singer and composer
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