VER-3323

VER-3323
Identifiers
	IUPAC name (2S)-1-(6-bromo-2,3-dihydroindol-1-yl)propan-2-amine;
CAS Number	259857-99-3;
PubChem CID	6604042;
IUPHAR/BPS	168;
ChemSpider	5036348;
ChEMBL	ChEMBL309760;
Chemical and physical data
Formula	C11H15BrN2
Molar mass	255.159 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C[C@@H](CN1CCc2c1cc(cc2)Br)N;
	InChI InChI=1S/C11H15BrN2/c1-8(13)7-14-5-4-9-2-3-10(12)6-11(9)14/h2-3,6,8H,4-5,7,13H2,1H3/t8-/m0/s1; Key:QGRQJMXAQYGAKK-QMMMGPOBSA-N;
	(verify)

VER-3323 is a drug which acts as a selective agonist for both the 5-HT_2B and 5-HT_2C serotonin receptor subtypes, with moderate selectivity for 5-HT_2C, but relatively low affinity for 5-HT_2A. It has potent anorectic effects in animal studies.^[1]^[2]^[3]^[4]

References

↑ Knight AR, Misra A, Quirk K, Benwell K, Revell D, Kennett G, Bickerdike M (August 2004). "Pharmacological characterisation of the agonist radioligand binding site of 5-HT(2A), 5-HT(2B) and 5-HT(2C) receptors". Naunyn-Schmiedeberg's Archives of Pharmacology. 370 (2): 114–23. doi:10.1007/s00210-004-0951-4. PMID 15322733. S2CID 8938111.
↑ Halford JC, Harrold JA, Lawton CL, Blundell JE (March 2005). "Serotonin (5-HT) drugs: effects on appetite expression and use for the treatment of obesity". Current Drug Targets. 6 (2): 201–13. doi:10.2174/1389450053174550. PMID 15777190.
↑ Schuhler S, Clark A, Joseph W, Patel A, Lehnen K, Stratford E, Horan TL, Fone KC, Ebling FJ (May 2005). "Involvement of 5-HT receptors in the regulation of food intake in Siberian hamsters". Journal of Neuroendocrinology. 17 (5): 276–85. doi:10.1111/j.1365-2826.2005.01303.x. PMID 15869562. S2CID 31333248.
↑ Song J, Hanniford D, Doucette C, Graham E, Poole MF, Ting A, Sherf B, Harrington J, Brunden K, Stricker-Krongrad A (December 2005). "Development of homogeneous high-affinity agonist binding assays for 5-HT2 receptor subtypes". ASSAY and Drug Development Technologies. 3 (6): 649–59. doi:10.1089/adt.2005.3.649. PMID 16438660.

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[pmid15322733-1] Knight AR, Misra A, Quirk K, Benwell K, Revell D, Kennett G, Bickerdike M (August 2004). "Pharmacological characterisation of the agonist radioligand binding site of 5-HT(2A), 5-HT(2B) and 5-HT(2C) receptors". Naunyn-Schmiedeberg's Archives of Pharmacology. 370 (2): 114–23. doi:10.1007/s00210-004-0951-4. PMID 15322733. S2CID 8938111.

[pmid15777190-2] Halford JC, Harrold JA, Lawton CL, Blundell JE (March 2005). "Serotonin (5-HT) drugs: effects on appetite expression and use for the treatment of obesity". Current Drug Targets. 6 (2): 201–13. doi:10.2174/1389450053174550. PMID 15777190.

[pmid15869562-3] Schuhler S, Clark A, Joseph W, Patel A, Lehnen K, Stratford E, Horan TL, Fone KC, Ebling FJ (May 2005). "Involvement of 5-HT receptors in the regulation of food intake in Siberian hamsters". Journal of Neuroendocrinology. 17 (5): 276–85. doi:10.1111/j.1365-2826.2005.01303.x. PMID 15869562. S2CID 31333248.

[pmid16438660-4] Song J, Hanniford D, Doucette C, Graham E, Poole MF, Ting A, Sherf B, Harrington J, Brunden K, Stricker-Krongrad A (December 2005). "Development of homogeneous high-affinity agonist binding assays for 5-HT2 receptor subtypes". ASSAY and Drug Development Technologies. 3 (6): 649–59. doi:10.1089/adt.2005.3.649. PMID 16438660.

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See also

References