World War II

After a brief shakedown in the Gulf of Mexico followed by a short availability, the store ship departed Galveston on 31 January and steamed to Mobile, Alabama, to receive her initial load. She departed the United States on 7 February as part of Service Squadron 9 and shuttled provisions to various ships and shore activities throughout the Pacific Ocean, primarily in the Philippine Islands, the Admiralty Islands, and the Netherlands East Indies.

Before the end of October 1945, Arequipa had serviced 905 ships and 41 shore activities and travelled over 35,000 miles. On 19 December, she went into drydock at Manicani Island in Leyte Gulf.

Cold War

Following overhaul, Arequipa returned to the United States and picked up provisions in San Francisco, California, for delivery to ports throughout the Pacific Islands, Japan, and China. From May 1946 until November 1954, the stores ship delivered supplies, almost without interruption except for periodic repair and overhaul.

Decommissioning and fate

Arequipa underwent a pre-inactivation overhaul at Pearl Harbor from November 1954 to June 1955 and then steamed to San Diego, California, to join the Pacific Reserve Fleet. She was decommissioned on 25 August 1955, and her name was struck from the Navy list on 1 September 1961. She was sold in December 1972 to Star-Kist Foods, Inc., of Terminal Island, California, for non-transportation use. The Arequipa was toured by a former crewman, Don King USN (Ret), in San Diego prior to being towed offshore and scuttled to become an artificial reef.