USP33

USP33
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2UZG
Identifiers
Aliases	USP33, VDU1, ubiquitin specific peptidase 33
External IDs	OMIM: 615146 MGI: 2159711 HomoloGene: 8996 GeneCards: USP33
Gene location (Human)
Chr.	Chromosome 1 (human)
End	77,759,852 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	152,099,254 bp
RNA expression pattern
	Top expressed in
	cerebellar vermis; ; Brodmann area 23; ; retinal pigment epithelium; ; pons; ; parietal pleura; ; endothelial cell; ; middle temporal gyrus; ; superior vestibular nucleus; ; palpebral conjunctiva; ; parietal lobe;
	Top expressed in
	ventromedial nucleus; ; ventral tegmental area; ; mammillary body; ; dorsomedial hypothalamic nucleus; ; pontine nuclei; ; habenula; ; lateral hypothalamus; ; dorsal tegmental nucleus; ; medial vestibular nucleus; ; cerebellar vermis;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	cysteine-type peptidase activity; zinc ion binding; metal ion binding; peptidase activity; ubiquitin binding; protein binding; thiol-dependent deubiquitinase; cysteine-type endopeptidase activity; hydrolase activity; G protein-coupled receptor binding;
Cellular component	cytoplasm; cell body; centrosome; Golgi apparatus; VCB complex; focal adhesion; nucleoplasm; microtubule organizing center; autophagosome; perinuclear region of cytoplasm; cytoskeleton; cytosol;
Biological process	endocytosis; protein K48-linked deubiquitination; ubiquitin-dependent protein catabolic process; regulation of G protein-coupled receptor signaling pathway; centrosome duplication; cellular response to starvation; protein stabilization; negative regulation of protein binding; proteolysis; axon guidance; regulation of autophagy; protein K63-linked deubiquitination; positive regulation of protein binding; cell migration; protein deubiquitination;
	Sources:Amigo / QuickGO
Orthologs
	23032
	170822
	ENSG00000077254
	ENSMUSG00000025437
	Q8TEY7
	Q8R5K2
	NM_015017; NM_201624; NM_201626
	NM_001076676; NM_001252486; NM_133247; NM_001355666
NP_055832; NP_963918; NP_963920; NP_001364359; NP_001364360;
	NP_001364361; NP_001364362; NP_001364363; NP_001364364; NP_001364365; NP_001364366; NP_001364367; NP_001364368
	NP_001070144; NP_001239415; NP_573510; NP_001342595
	Wikidata
View/Edit Human	View/Edit Mouse

Ubiquitin carboxyl-terminal hydrolase 33 is an enzyme that in humans is encoded by the USP33 gene.^[5]^[6]

Interactions

USP33 has been shown to interact with DIO2,^[7] SELENBP1^[8] and Von Hippel–Lindau tumor suppressor.^[9]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000077254 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025437 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Puente XS, Sánchez LM, Overall CM, López-Otín C (Jul 2003). "Human and mouse proteases: a comparative genomic approach". Nat Rev Genet. 4 (7): 544–558. doi:10.1038/nrg1111. PMID 12838346. S2CID 2856065.
↑ "Entrez Gene: USP33 ubiquitin specific peptidase 33".
↑ Curcio-Morelli C, Zavacki AM, Christofollete M, Gereben B, de Freitas BC, Harney JW, Li Z, Wu G, Bianco AC (Jul 2003). "Deubiquitination of type 2 iodothyronine deiodinase by von Hippel-Lindau protein-interacting deubiquitinating enzymes regulates thyroid hormone activation". J. Clin. Invest. 112 (2): 189–196. doi:10.1172/JCI18348. PMC 164294. PMID 12865408.
↑ Jeong JY, Wang Y, Sytkowski AJ (Feb 2009). "Human selenium binding protein-1 (hSP56) interacts with VDU1 in a selenium-dependent manner". Biochem. Biophys. Res. Commun. 379 (2): 583–588. doi:10.1016/j.bbrc.2008.12.110. PMID 19118533.
↑ Li Z, Na X, Wang D, Schoen SR, Messing EM, Wu G (Feb 2002). "Ubiquitination of a novel deubiquitinating enzyme requires direct binding to von Hippel-Lindau tumor suppressor protein". J. Biol. Chem. 277 (7): 4656–4662. doi:10.1074/jbc.M108269200. PMID 11739384.

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Kikuno R, Nagase T, Ishikawa K, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (1999). "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (3): 197–205. doi:10.1093/dnares/6.3.197. PMID 10470851.
Li Z, Na X, Wang D, Schoen SR, Messing EM, Wu G (2002). "Ubiquitination of a novel deubiquitinating enzyme requires direct binding to von Hippel-Lindau tumor suppressor protein". J. Biol. Chem. 277 (7): 4656–4662. doi:10.1074/jbc.M108269200. PMID 11739384.
Li Z, Wang D, Na X, Schoen SR, Messing EM, Wu G (2002). "Identification of a deubiquitinating enzyme subfamily as substrates of the von Hippel-Lindau tumor suppressor". Biochem. Biophys. Res. Commun. 294 (3): 700–709. doi:10.1016/S0006-291X(02)00534-X. PMID 12056827.
Curcio-Morelli C, Zavacki AM, Christofollete M, Gereben B, de Freitas BC, Harney JW, Li Z, Wu G, Bianco AC (2003). "Deubiquitination of type 2 iodothyronine deiodinase by von Hippel-Lindau protein-interacting deubiquitinating enzymes regulates thyroid hormone activation". J. Clin. Invest. 112 (2): 189–196. doi:10.1172/JCI18348. PMC 164294. PMID 12865408.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Allen MD, Bycroft M (2007). "The solution structure of the ZnF UBP domain of USP33/VDU1". Protein Sci. 16 (9): 2072–2075. doi:10.1110/ps.072967807. PMC 2206988. PMID 17766394.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000077254 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025437 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12838346-5] Puente XS, Sánchez LM, Overall CM, López-Otín C (Jul 2003). "Human and mouse proteases: a comparative genomic approach". Nat Rev Genet. 4 (7): 544–558. doi:10.1038/nrg1111. PMID 12838346. S2CID 2856065.

[entrez-6] "Entrez Gene: USP33 ubiquitin specific peptidase 33".

[pmid12865408-7] Curcio-Morelli C, Zavacki AM, Christofollete M, Gereben B, de Freitas BC, Harney JW, Li Z, Wu G, Bianco AC (Jul 2003). "Deubiquitination of type 2 iodothyronine deiodinase by von Hippel-Lindau protein-interacting deubiquitinating enzymes regulates thyroid hormone activation". J. Clin. Invest. 112 (2): 189–196. doi:10.1172/JCI18348. PMC 164294. PMID 12865408.

[pmid19118533-8] Jeong JY, Wang Y, Sytkowski AJ (Feb 2009). "Human selenium binding protein-1 (hSP56) interacts with VDU1 in a selenium-dependent manner". Biochem. Biophys. Res. Commun. 379 (2): 583–588. doi:10.1016/j.bbrc.2008.12.110. PMID 19118533.

[pmid11739384-9] Li Z, Na X, Wang D, Schoen SR, Messing EM, Wu G (Feb 2002). "Ubiquitination of a novel deubiquitinating enzyme requires direct binding to von Hippel-Lindau tumor suppressor protein". J. Biol. Chem. 277 (7): 4656–4662. doi:10.1074/jbc.M108269200. PMID 11739384.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

Interactions

References

Further reading