Characters

Main

• Timmy the Tooth (performed by Kevin Carlson) is the main protagonist. He is an adventurous tooth that lives with his best friend Brushbrush and is prone to burst into song.
• Brushbrush (performed by Todd Mattox) – Timmy's pet toothbrush who behaves like a dog. He whispers or bristles his words, although Timmy is the only one who can understand him unlike the other characters.
• Bubbles Gum (performed by Cheryl Blaylock) is Timmy's blue-skinned friend is always ready to help Timmy as well as go on an adventure. She tends to take lead of things, and usually calls Timmy by his full name.
• Miss Flossy (performed by Michael Earl) is a cowgirl of sorts who is constantly having a good time. Despite her name, she has a blob-like appearance.
  • Waxie is Flossie's unicorn-type hobby horse.
• Sidney Cyclops (performed by Bruce Lanoil) is a one-eyed male monster and Timmy's friend who wants to become the greatest paper boy in the world. He is much younger than Timmy and looks up to him as his best friend.
• Annette Bruner Prower (performed by Christine Papelexis) is Timmy's yellow-skinned friend is exactly a ditz, but always there for her friends. Her other name is also Full of Jello, her general middle and last names are Bruner and Prower.
• Johnny Paste (performed by Allan Trautman) is a large muscular tube of toothpaste who is another one of Timmy's friends. He is well-meaning, but not all that bright.
• Mr. Wisdom (performed by Phil Baron) is an old wisdom tooth who lives up on Wisdom Mountain. He gives advice to Timmy and his friends when they need it.

Supporting

• Sherry (performed by Allan Trautman) is an elderly female fairy who is the local fortune teller.
• Gil (performed by Allan Trautman) is a grinning green grouper.
• Sunny (performed by Allan Trautman in most episodes, Phil Baron in "Malibu Timmy") is a hot and smiling sun that wears sunglasses.
• Leggs O'Many (performed by Todd Mattox) is a cool piano-playing octopus.
• Nicki and Irene (performed by Christine Papelexis and Dina Fraboni) are the two flowers in Timmy's front yard. They both love the rain and love to be watered.
• Emmett (performed by Greg Ballora) is Timmy's mailbox.
• Thirstin and Windslow (performed by Greg Ballora and Kevin Carlson) are two clouds.
• Clem (performed by Greg Ballora) –
• Bunky (performed by Michael Earl) –

Villains

• The Cavity Goon (performed by James Murray) is the main antagonist of the series. The Cavity Goon (otherwise known as Goonius Nemesis III) is a disgusting sight...a green creature covered with spots and a mouth full of decayed sharp teeth. He wears clothes that appear to be made of ripped-up leaves and is constantly bothering Timmy and his friends. In the episode "Lost My Brush", he even tried to kidnap Timmy by using the kidnapped Brushbrush to lure him in an attempt to turn him over to the Tooth Fairy for money.
  • Miss Sweety (performed by Bruce Lanoil)^[2] is the Cavity Goon's sidekick. She is an enormous peppermint candy on a stick who always joins her boss on his evil plots.
• The Gingivitis Gang are a group of ambiguous creatures and the secondary antagonists. Although their hobbies include looking for trouble and harassing Timmy and his friends, they are not inherently evil and even occasionally assist Timmy.
  • Leo (performed by Phil Baron) is the red-horned, lavender-haired, blue-skinned leader of the Gingivitis Gang.
  • Kay (performed by Bruce Lanoil) is the orange-skinned, red haired, female bird-like member of the Gingivitis Gang.
  • Dee (performed by Dina Fraboni) is the blonde-haired, pinkish orange-skinned, female insect-like member of the Gingivitis Gang.
  • Darol (performed by James Murray) is the blue-haired, green-skinned member of the Gingivitis Gang.
  • Nolan (performed by Kevin Carlson) is the rose-colored, yellow-haired, hook-nosed, and green-horned member of the Gingivitis Gang.