TRIM11

TRIM11
Identifiers
Aliases	TRIM11, BIA1, RNF92, tripartite motif containing 11
External IDs	OMIM: 607868 MGI: 2137355 HomoloGene: 14225 GeneCards: TRIM11
Gene location (Human)
Chr.	Chromosome 1 (human)
End	228,406,835 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	58,882,284 bp
RNA expression pattern
	Top expressed in
	cerebellar hemisphere; ; oocyte; ; spleen; ; blood; ; cerebellar vermis; ; monocyte; ; putamen; ; nucleus accumbens; ; caudate nucleus; ; pancreatic ductal cell;
	Top expressed in
	secondary oocyte; ; spermatocyte; ; corneal stroma; ; thymus; ; atrium; ; seminiferous tubule; ; entorhinal cortex; ; interventricular septum; ; blood; ; proximal tubule;
	More reference expression data
	n/a
Gene ontology
Molecular function	ubiquitin-protein transferase activity; zinc ion binding; transcription factor binding; protein binding; protein domain specific binding; ubiquitin protein ligase activity; metal ion binding; transferase activity;
Cellular component	cytoplasm; intracellular anatomical structure; nucleus; cytosol;
Biological process	negative regulation of neurogenesis; innate immune response; negative regulation of transcription, DNA-templated; defense response to virus; protein ubiquitination; negative regulation of viral transcription; negative regulation of viral entry into host cell; positive regulation of viral entry into host cell;
	Sources:Amigo / QuickGO
Orthologs
	81559
	94091
	ENSG00000154370
	ENSMUSG00000020455
	Q96F44
	Q99PQ2
	NM_145214
	NM_001290988; NM_053168
	NP_660215
	NP_001277917; NP_444398
	Wikidata
View/Edit Human	View/Edit Mouse

Tripartite motif-containing protein 11 is a protein found in humans that is encoded by the TRIM11 gene.^[5]^[6]

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the nucleus and the cytoplasm. Its function has not been identified.^[6]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000154370 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000020455 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Reymond A, Meroni G, Fantozzi A, Merla G, Cairo S, Luzi L, Riganelli D, Zanaria E, Messali S, Cainarca S, Guffanti A, Minucci S, Pelicci PG, Ballabio A (May 2001). "The tripartite motif family identifies cell compartments". EMBO J. 20 (9): 2140–51. doi:10.1093/emboj/20.9.2140. PMC 125245. PMID 11331580.
1 2 "Entrez Gene: TRIM11 tripartite motif-containing 11".

Ishikawa H, Tachikawa H, Miura Y, Takahashi N (2006). "TRIM11 binds to and destabilizes a key component of the activator-mediated cofactor complex (ARC105) through the ubiquitin-proteasome system". FEBS Lett. 580 (20): 4784–92. doi:10.1016/j.febslet.2006.07.066. PMID 16904669. S2CID 33550003.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Cooper ST, Hanson IM (2006). "A screen for proteins that interact with PAX6: C-terminal mutations disrupt interaction with HOMER3, DNCL1 and TRIM11". BMC Genet. 6: 43. doi:10.1186/1471-2156-6-43. PMC 1208879. PMID 16098226.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Niikura T, Hashimoto Y, Tajima H, et al. (2003). "A tripartite motif protein TRIM11 binds and destabilizes Humanin, a neuroprotective peptide against Alzheimer's disease-relevant insults". Eur. J. Neurosci. 17 (6): 1150–8. doi:10.1046/j.1460-9568.2003.02553.x. PMID 12670303. S2CID 1345339.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000154370 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000020455 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11331580-5] Reymond A, Meroni G, Fantozzi A, Merla G, Cairo S, Luzi L, Riganelli D, Zanaria E, Messali S, Cainarca S, Guffanti A, Minucci S, Pelicci PG, Ballabio A (May 2001). "The tripartite motif family identifies cell compartments". EMBO J. 20 (9): 2140–51. doi:10.1093/emboj/20.9.2140. PMC 125245. PMID 11331580.

[entrez-6] 1 2 "Entrez Gene: TRIM11 tripartite motif-containing 11".

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References

Further reading