TPK1

TPK1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3S4Y
Identifiers
Aliases	TPK1, HPP20, THMD5, thiamin pyrophosphokinase 1
External IDs	OMIM: 606370 MGI: 1352500 HomoloGene: 6960 GeneCards: TPK1
Gene location (Human)
Chr.	Chromosome 7 (human)
End	144,836,395 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	43,643,212 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; jejunal mucosa; ; monocyte; ; duodenum; ; Achilles tendon; ; blood; ; endothelial cell; ; palpebral conjunctiva; ; rectum; ; retinal pigment epithelium;
	Top expressed in
	proximal tubule; ; epithelium of stomach; ; kidney; ; pyloric antrum; ; ileum; ; duodenum; ; jejunum; ; mucous cell of stomach; ; left lobe of liver; ; colon;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	thiamine diphosphokinase activity; transferase activity; thiamine binding; nucleotide binding; ATP binding; kinase activity;
Cellular component	cytosol;
Biological process	thiamine metabolic process; thiamine diphosphate biosynthetic process; phosphorylation; thiamine-containing compound metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	27010
	29807
	ENSG00000196511
	ENSMUSG00000029735
	Q9H3S4
	Q9R0M5
NM_001042482; NM_022445; NM_001350879; NM_001350880; NM_001350881;
	NM_001350882; NM_001350883; NM_001350884; NM_001350885; NM_001350886; NM_001350887; NM_001350889; NM_001350893; NM_001350894; NM_001350895
	NM_013861; NM_001311111
NP_001035947; NP_071890; NP_001337808; NP_001337809; NP_001337810;
	NP_001337811; NP_001337812; NP_001337813; NP_001337814; NP_001337815; NP_001337816; NP_001337818; NP_001337822; NP_001337823; NP_001337824
	NP_001298040; NP_038889
	Wikidata
View/Edit Human	View/Edit Mouse

Thiamin pyrophosphokinase 1 is an enzyme that in humans is encoded by the TPK1 gene.^[5]^[6]

This gene encodes a protein, that exists as a homodimer, which catalyzes the conversion of thiamine to thiamine pyrophosphate. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.^[6]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000196511 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029735 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Nosaka K, Onozuka M, Kakazu N, Hibi S, Nishimura H, Nishino H, Abe T (May 2001). "Isolation and characterization of a human thiamine pyrophosphokinase cDNA". Biochim Biophys Acta. 1517 (2): 293–7. doi:10.1016/s0167-4781(00)00247-5. PMID 11342111.
1 2 "Entrez Gene: TPK1 thiamin pyrophosphokinase 1".

Egi Y, Koyama S, Shioda T, et al. (1992). "Identification, purification and reconstitution of thiamin metabolizing enzymes in human red blood cells". Biochim. Biophys. Acta. 1160 (2): 171–8. doi:10.1016/0167-4838(92)90004-W. PMID 1332781.
Bohn H, Winckler W (1985). "Isolation and characterization of four new placental tissue proteins (PP18, PP19, PP20, PP21)". Arch. Gynecol. 236 (4): 235–42. doi:10.1007/BF02133941. PMID 3896163. S2CID 6395375.
Iwashima A, Kinugasa A, Nose Y (1983). "Radiometric assay for thiamine pyrophosphokinase activity in human leukocytes". Acta Vitaminol. Enzymol. 5 (1): 41–5. PMID 6303095.
<Please add first missing authors to populate metadata.> (1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074.
Nosaka K, Onozuka M, Nishino H, et al. (1999). "Molecular cloning and expression of a mouse thiamin pyrophosphokinase cDNA". J. Biol. Chem. 274 (48): 34129–33. doi:10.1074/jbc.274.48.34129. PMID 10567383.
Zhao R, Gao F, Goldman ID (2001). "Molecular cloning of human thiamin pyrophosphokinase". Biochim. Biophys. Acta. 1517 (2): 320–2. doi:10.1016/s0167-4781(00)00264-5. PMID 11342117.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human Chromosome 7: DNA Sequence and Biology". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
Onozuka M, Nosaka K (2004). "Steady-state kinetics and mutational studies of recombinant human thiamin pyrophosphokinase". J. Nutr. Sci. Vitaminol. 49 (3): 156–62. doi:10.3177/jnsv.49.156. PMID 12953792.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Bellyei S, Szigeti A, Boronkai A, et al. (2005). "Cloning, sequencing, structural and molecular biological characterization of placental protein 20 (PP20)/human thiamin pyrophosphokinase (hTPK)". Placenta. 26 (1): 34–46. doi:10.1016/j.placenta.2004.03.008. PMID 15664409.
Toyoshima M, Oka A, Egi Y, et al. (2005). "Thiamine-responsive congenital lactic acidosis: clinical and biochemical studies" (PDF). Pediatr. Neurol. 33 (2): 98–104. doi:10.1016/j.pediatrneurol.2005.02.007. PMID 16087053.
Onozuka M, Konno H, Akaji K, et al. (2006). "Molecular cloning and analysis of the 5'-flanking region of the human thiamin pyrophosphokinase gene". J. Nutr. Sci. Vitaminol. 51 (4): 274–7. doi:10.3177/jnsv.51.274. PMID 16262001.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Fradin D, Bougneres P (2007). "Three common intronic variants in the maternal and fetal thiamine pyrophosphokinase gene (TPK1) are associated with birth weight" (PDF). Ann. Hum. Genet. 71 (Pt 5): 578–85. doi:10.1111/j.1469-1809.2007.00348.x. PMID 17295612. S2CID 29631405.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000196511 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029735 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11342111-5] Nosaka K, Onozuka M, Kakazu N, Hibi S, Nishimura H, Nishino H, Abe T (May 2001). "Isolation and characterization of a human thiamine pyrophosphokinase cDNA". Biochim Biophys Acta. 1517 (2): 293–7. doi:10.1016/s0167-4781(00)00247-5. PMID 11342111.

[entrez-6] 1 2 "Entrez Gene: TPK1 thiamin pyrophosphokinase 1".

[1]

[2]

[3]

[4]

[5]

[6]

Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

References

Further reading