TPCN1
Identifiers
AliasesTPCN1, TPC1, two pore segment channel 1
External IDsOMIM: 609666 MGI: 2182472 HomoloGene: 9905 GeneCards: TPCN1
Orthologs
SpeciesHumanMouse
Entrez

53373

252972

Ensembl

ENSG00000186815

ENSMUSG00000032741

UniProt

Q9ULQ1

Q9EQJ0

RefSeq (mRNA)

NM_001143819
NM_001301214
NM_017901
NM_001351346
NM_001351347

NM_145853

RefSeq (protein)

NP_001137291
NP_001288143
NP_060371
NP_001338275
NP_001338276

NP_665852

Location (UCSC)Chr 12: 113.22 – 113.3 MbChr 5: 120.67 – 120.73 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Two pore segment channel 1 (TPC1) is a human protein encoded by the TPCN1 gene.[5] The protein encoded by this gene is an ion channel. In contrast to other calcium and sodium channels which have four homologous domains, each containing 6 transmembrane segments (S1 to S6), TPCN1 only contains two domains (each containing segments S1 to S6).[6][7][8]

Structure

The structure of a TPC1 ortholog from Arabidopsis thaliana has been solved by two laboratories.[9][10] The structures were solved using X-ray crystallography and contained the fold of a voltage-gated ion channel and EF hands. Only a single voltage sensor domain appears to responsible for voltage sensing.

Filoviral Infections

Genetic knockout and pharmacological inhibition experiments demonstrate that Two-pore Channels, TPC1 and TPC2, are required for infection by Filoviruses Ebola and Marburg in mice.[11]

See also

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000186815 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032741 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ↑ "Entrez Gene: two pore segment channel 1".
  6. ↑ Hirosawa M, Nagase T, Ishikawa K, Kikuno R, Nomura N, Ohara O (October 1999). "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain". DNA Research. 6 (5): 329–36. doi:10.1093/dnares/6.5.329. PMID 10574461.
  7. ↑ Ishibashi K, Suzuki M, Imai M (April 2000). "Molecular cloning of a novel form (two-repeat) protein related to voltage-gated sodium and calcium channels". Biochemical and Biophysical Research Communications. 270 (2): 370–6. doi:10.1006/bbrc.2000.2435. PMID 10753632.
  8. ↑ Clapham DE, Garbers DL (December 2005). "International Union of Pharmacology. L. Nomenclature and structure-function relationships of CatSper and two-pore channels". Pharmacological Reviews. 57 (4): 451–4. doi:10.1124/pr.57.4.7. PMID 16382101. S2CID 35096827.
  9. ↑ Guo J, Zeng W, Chen Q, Lee C, Chen L, Yang Y, Cang C, Ren D, Jiang Y (March 2016). "Structure of the voltage-gated two-pore channel TPC1 from Arabidopsis thaliana". Nature. 531 (7593): 196–201. Bibcode:2016Natur.531..196G. doi:10.1038/nature16446. PMC 4841471. PMID 26689363.
  10. ↑ Kintzer AF, Stroud RM (March 2016). "Structure, inhibition and regulation of two-pore channel TPC1 from Arabidopsis thaliana". Nature. 531 (7593): 258–62. Bibcode:2016Natur.531..258K. doi:10.1038/nature17194. PMC 4863712. PMID 26961658.
  11. ↑ Sakurai Y, Kolokoltsov AA, Chen CC, Tidwell MW, Bauta WE, Klugbauer N, Grimm C, Wahl-Schott C, Biel M, Davey RA (February 2015). "Ebola virus. Two-pore channels control Ebola virus host cell entry and are drug targets for disease treatment". Science. 347 (6225): 995–8. doi:10.1126/science.1258758. PMC 4550587. PMID 25722412.

Further reading

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