TP53RK
Identifiers
AliasesTP53RK, BUD32, C20orf64, Nori-2, Nori-2p, PRPK, dJ101A2, TP53 regulating kinase, GAMOS4, TPRKB
External IDsOMIM: 608679 MGI: 1914050 HomoloGene: 6042 GeneCards: TP53RK
EC number3.6.-.-
Orthologs
SpeciesHumanMouse
Entrez

112858

76367

Ensembl

ENSG00000172315

ENSMUSG00000042854

UniProt

Q96S44

Q99PW4

RefSeq (mRNA)

NM_033550

NM_023815

RefSeq (protein)

NP_291028

NP_076304.2

Location (UCSC)Chr 20: 46.68 – 46.69 MbChr 2: 166.63 – 166.64 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

TP53-regulating kinase, also known as PRPK is an enzyme that in humans is encoded by the TP53RK gene.[5][6][7] This protein is a serine/threonine protein kinase that phosphorylates p53 at Ser15.

PRPK is part of the KEOPS/EKC complex, which participates in transcription control,[8] telomere regulation [9] and tRNA modification.[10]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000172315 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000042854 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Abe Y, Matsumoto S, Wei S, Nezu K, Miyoshi A, Kito K, Ueda N, Shigemoto K, Hitsumoto Y, Nikawa J, Enomoto Y (Nov 2001). "Cloning and characterization of a p53-related protein kinase expressed in interleukin-2-activated cytotoxic T-cells, epithelial tumor cell lines, and the testes". The Journal of Biological Chemistry. 276 (47): 44003–11. doi:10.1074/jbc.M105669200. PMID 11546806.
  6. Facchin S, Lopreiato R, Ruzzene M, Marin O, Sartori G, Götz C, Montenarh M, Carignani G, Pinna LA (Aug 2003). "Functional homology between yeast piD261/Bud32 and human PRPK: both phosphorylate p53 and PRPK partially complements piD261/Bud32 deficiency". FEBS Letters. 549 (1–3): 63–6. doi:10.1016/S0014-5793(03)00770-1. PMID 12914926. S2CID 24581860.
  7. "Entrez Gene: TP53RK TP53 regulating kinase".
  8. Kisseleva-Romanova E, Lopreiato R, Baudin-Baillieu A, Rousselle JC, Ilan L, Hofmann K, Namane A, Mann C, Libri D (Aug 2006). "Yeast homolog of a cancer-testis antigen defines a new transcription complex". The EMBO Journal. 25 (15): 3576–85. doi:10.1038/sj.emboj.7601235. PMC 1538566. PMID 16874308.
  9. Downey M, Houlsworth R, Maringele L, Rollie A, Brehme M, Galicia S, Guillard S, Partington M, Zubko MK, Krogan NJ, Emili A, Greenblatt JF, Harrington L, Lydall D, Durocher D (Mar 2006). "A genome-wide screen identifies the evolutionarily conserved KEOPS complex as a telomere regulator". Cell. 124 (6): 1155–68. doi:10.1016/j.cell.2005.12.044. PMID 16564010. S2CID 13928061.
  10. Srinivasan M, Mehta P, Yu Y, Prugar E, Koonin EV, Karzai AW, Sternglanz R (Mar 2011). "The highly conserved KEOPS/EKC complex is essential for a universal tRNA modification, t6A". The EMBO Journal. 30 (5): 873–81. doi:10.1038/emboj.2010.343. PMC 3049205. PMID 21183954.

Further reading


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