Sofia Mensurado
Born1992
Alma materFaculty of Sciences of the University of Lisbon
OccupationScientist
EmployerInstituto de Medicina Molecular

Sofia Mensurado (1992) is a Portuguese scientist whose research focuses on molecular processes in breast cancer immunotherapy.[1] Her team won the Janssen prize in 2018.[2]

Biography

Sofia Mensurado Silva graduated in medical sciences from the University of Lisbon and did her master's degree in biochemistry at the Faculty of Sciences of the University of Lisbon, developing her thesis at the iMM (João Lobo Antunes Institute of Molecular Medicine).[3] She did her PhD in Bruno Silva-Santos' laboratory at the same institute.[4] Since 2020, she has been a postdoctoral researcher at the iMM.[5]

Her research studies the role of T lymphocytes in the immune response to cancer, specifically the neutralization of gamma-delta T cells, which help tumor proliferation.[6] Sofia Mensurado studies the efficacy of methionine (an amino acid, a component of proteins, present in our diet) in boosting immunotherapy as a treatment for breast cancer.[1][7]

Awards

Her doctoral project, entitled "Regulation of T cell fitness and function in the tumour microenvironment", was funded with a doctoral scholarship from the FCT (Foundation for Science and Technology) in 2015.[4] In April 2016, she received an award from the Portuguese Society of Immunology for a trip abroad.[8]

In 2018, together with Bruno Silva-Santos and Karine Serre, he won the 2nd edition of the Janssen Innovation prize, worth €30,000, for the research "Tumor-associated neutrophils suppress pro-tumoral IL-17+ γδ T cells through induction of oxidative stress".[2][9] This study was also supported by the iMM-Laço Fund, awarded by Associação Laço in partnership with iMM (Instituto de Medicina Molecular – João Lobo Antunes).[1][7][10]

Works

She has co-authored several scientific articles:[4][11][12]

  • 2019 – γδ T cells: pleiotropic immune effectors with therapeutic potential in cancer, Nature Reviews Cancer[13]
  • 2019 – γδ-T cells promote IFN-γ–dependent Plasmodium pathogenesis upon liver-stage infection, PNAS[14]
  • 2018 – Tumor-associated neutrophils suppress pro-tumoral IL-17+ γδ T cells through induction of oxidative stress, PLOS Biology[15]
  • 2017 – IL‐23 drives differentiation of peripheral γδ17 T cells from adult bone marrow‐derived precursors, EMBO Reports[16]
  • 2014 – Murine CD27((-)) V gamma 6((+)) gamma delta T cells producing IL-17A promote ovarian cancer growth via mobilization of protumor small peritoneal macrophages, PNAS[17]

References

  1. 1 2 3 "Ciência avança contra o cancro de mama". www.dn.pt (in European Portuguese). 2020-10-05. Retrieved 2023-11-03.
  2. 1 2 "Já são conhecidos os vencedores da 2.ª edição do Prémio Janssen Inovação - News Farma". www.newsfarma.pt (in European Portuguese). Retrieved 2023-11-03.
  3. ↑ "Highlights 2016 – Instituto Medicina Molecular" (PDF). imm.medicina.ulisboa.pt.
  4. 1 2 3 "ORCID". orcid.org. Retrieved 2023-11-03.
  5. ↑ "Sofia Mensurado". iMM. Retrieved 2023-11-03.
  6. ↑ "Ribot & Silva-Santos Lab". iMM. Retrieved 2023-11-03.
  7. 1 2 Rosa, Rita Robalo (2020-10-23). "A alimentação pode fazer diferença no combate ao cancro da mama, mas o rastreio é o mais importante". PÚBLICO (in Portuguese). Retrieved 2023-11-03.
  8. ↑ "Travel Grants | SPI | Sociedade Portuguesa de Imunologia". 2020-09-25. Archived from the original on 2020-09-25. Retrieved 2023-11-03.
  9. ↑ "2.ª Edição do Prémio Janssen Inovação | Janssen Portugal". janssen.com. 2020-10-30. Archived from the original on 2020-10-30. Retrieved 2023-11-03.
  10. ↑ "Activa | Sofia Mensurado, investigadora, fala-nos sobre o cancro da mama e os mais recentes avanços na luta contra esta doença". Activa (in European Portuguese). 2020-10-06. Retrieved 2023-11-03.
  11. ↑ "Sofia Mensurado". researchgate.net.
  12. ↑ "Web of Science". www.webofscience.com. Retrieved 2023-11-03.
  13. ↑ Silva-Santos, Bruno; Mensurado, Sofia; Coffelt, Seth B. (2019-07-17). "γδ T cells: pleiotropic immune effectors with therapeutic potential in cancer". Nature Reviews Cancer. 19 (7): 392–404. doi:10.1038/s41568-019-0153-5. ISSN 1474-1768. PMC 7614706. PMID 31209264.
  14. ↑ Ribot, Julie C.; Neres, Rita; Zuzarte-Luís, Vanessa; Gomes, Anita Q.; Mancio-Silva, Liliana; Mensurado, Sofia; Pinto-Neves, Daniel; Santos, Miguel M.; Carvalho, Tânia; Landry, Jonathan J. M.; Rolo, Eva A.; Malik, Ankita; Silva, Daniel Varón; Mota, Maria M.; Silva-Santos, Bruno (2019-05-14). "γδ-T cells promote IFN-γ–dependent Plasmodium pathogenesis upon liver-stage infection". Proceedings of the National Academy of Sciences. 116 (20): 9979–9988. Bibcode:2019PNAS..116.9979R. doi:10.1073/pnas.1814440116. ISSN 0027-8424. PMC 6525508. PMID 31028144.
  15. ↑ Mensurado, Sofia; Rei, Margarida; Lança, Telma; Ioannou, Marianna; Gonçalves-Sousa, Natacha; Kubo, Hiroshi; Malissen, Marie; Papayannopoulos, Venizelos; Serre, Karine; Silva-Santos, Bruno (2018-05-11). "Tumor-associated neutrophils suppress pro-tumoral IL-17+ γδ T cells through induction of oxidative stress". PLOS Biology. 16 (5): e2004990. doi:10.1371/journal.pbio.2004990. ISSN 1545-7885. PMC 5965901. PMID 29750788.
  16. ↑ Papotto, Pedro H; Gonçalves‐Sousa, Natacha; Schmolka, Nina; Iseppon, Andrea; Mensurado, Sofia; Stockinger, Brigitta; Ribot, Julie C; Silva‐Santos, Bruno (2017-08-30). "IL ‐23 drives differentiation of peripheral γδ17 T cells from adult bone marrow‐derived precursors". EMBO Reports. 18 (11): 1957–1967. doi:10.15252/embr.201744200. ISSN 1469-221X. PMC 5666615. PMID 28855306.
  17. ↑ Rei, Margarida; Gonçalves-Sousa, Natacha; Lança, Telma; Thompson, Richard G.; Mensurado, Sofia; Balkwill, Frances R.; Kulbe, Hagen; Pennington, Daniel J.; Silva-Santos, Bruno (2014-08-26). "Murine CD27(-) Vγ6(+) γδ T cells producing IL-17A promote ovarian cancer growth via mobilization of protumor small peritoneal macrophages". Proceedings of the National Academy of Sciences of the United States of America. 111 (34): E3562–3570. Bibcode:2014PNAS..111E3562R. doi:10.1073/pnas.1403424111. ISSN 1091-6490. PMC 4151711. PMID 25114209.
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