Selenophosphate synthetase 1

SEPHS1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3FD5, 3FD6
Identifiers
Aliases	SEPHS1, SELD, SPS, SPS1, Selenophosphate synthetase 1
External IDs	OMIM: 600902 MGI: 1923580 HomoloGene: 56558 GeneCards: SEPHS1
Gene location (Human)
Chr.	Chromosome 10 (human)
End	13,348,298 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	4,910,557 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; islet of Langerhans; ; oocyte; ; secondary oocyte; ; rectum; ; internal globus pallidus; ; right lobe of liver; ; left lobe of thyroid gland; ; endothelial cell; ; body of pancreas;
	Top expressed in
	maxillary prominence; ; condyle; ; ganglionic eminence; ; abdominal wall; ; primitive streak; ; internal carotid artery; ; external carotid artery; ; cumulus cell; ; medial ganglionic eminence; ; endocardial cushion;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; selenide, water dikinase activity; GTP binding; protein binding; ATP binding; protein homodimerization activity; identical protein binding; protein heterodimerization activity; kinase activity;
Cellular component	cytoplasm; plasma membrane; nuclear membrane; membrane; nucleus;
Biological process	phosphorylation; selenocysteine biosynthetic process; selenium compound metabolic process; tRNA seleno-modification;
	Sources:Amigo / QuickGO
Orthologs
	22929
	109079
	ENSG00000086475
	ENSMUSG00000026662
	P49903; Q5T5U7
	Q8BH69
	NM_001195602; NM_001195604; NM_012247; NM_001375769; NM_001375770
	NM_175400
	NP_001182531; NP_001182533; NP_036379; NP_001362698
	NP_780609; NP_001349636; NP_001349637; NP_001349638; NP_001349639
	Wikidata
View/Edit Human	View/Edit Mouse

Selenide, water dikinase 1 is an enzyme that in humans is encoded by the SEPHS1 gene.^[5]^[6]

This protein functions as an enzyme that synthesizes selenophosphate from selenide and ATP. Selenophosphate is the selenium donor used to synthesize selenocysteine, which is co-translationally incorporated into selenoproteins at in-frame UGA codons.^[6]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000086475 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026662 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Low SC; Harney JW; Berry MJ (Oct 1995). "Cloning and functional characterization of human selenophosphate synthetase, an essential component of selenoprotein synthesis". J Biol Chem. 270 (37): 21659–64. doi:10.1074/jbc.270.37.21659. PMID 7665581.
1 2 "Entrez Gene: SEPHS1 selenophosphate synthetase 1".

Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Tamura T, Yamamoto S, Takahata M, et al. (2004). "Selenophosphate synthetase genes from lung adenocarcinoma cells: Sps1 for recycling L-selenocysteine and Sps2 for selenite assimilation". Proc. Natl. Acad. Sci. U.S.A. 101 (46): 16162–7. Bibcode:2004PNAS..10116162T. doi:10.1073/pnas.0406313101. PMC 528966. PMID 15534230.
Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Saiki R, Nagata A, Kainou T, et al. (2005). "Characterization of solanesyl and decaprenyl diphosphate synthases in mice and humans". FEBS J. 272 (21): 5606–22. doi:10.1111/j.1742-4658.2005.04956.x. PMID 16262699. S2CID 13735213.
Chung HJ, Yoon SI, Shin SH, et al. (2006). "p53-Mediated enhancement of radiosensitivity by selenophosphate synthetase 1 overexpression". J. Cell. Physiol. 209 (1): 131–41. doi:10.1002/jcp.20714. PMID 16786570. S2CID 24313890.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000086475 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026662 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7665581-5] Low SC; Harney JW; Berry MJ (Oct 1995). "Cloning and functional characterization of human selenophosphate synthetase, an essential component of selenoprotein synthesis". J Biol Chem. 270 (37): 21659–64. doi:10.1074/jbc.270.37.21659. PMID 7665581.

[entrez-6] 1 2 "Entrez Gene: SEPHS1 selenophosphate synthetase 1".

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References

Further reading