STRN4

STRN4
Identifiers
Aliases	STRN4, ZIN, zinedin, PPP2R6C, striatin 4
External IDs	OMIM: 614767 MGI: 2142346 HomoloGene: 8378 GeneCards: STRN4
Gene location (Human)
Chr.	Chromosome 19 (human)
End	46,746,994 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	16,574,856 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; ganglionic eminence; ; stromal cell of endometrium; ; monocyte; ; left uterine tube; ; upper lobe of left lung; ; right coronary artery; ; body of stomach; ; canal of the cervix; ; popliteal artery;
	Top expressed in
	spermatocyte; ; spermatid; ; superior frontal gyrus; ; internal carotid artery; ; hippocampus proper; ; external carotid artery; ; piriform cortex; ; prefrontal cortex; ; ganglionic eminence; ; temporal lobe;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein phosphatase 2A binding; protein binding; calmodulin binding; armadillo repeat domain binding; protein domain specific binding; protein-containing complex binding;
Cellular component	cytoplasm; dendritic spine; protein phosphatase type 2A complex; cell projection; membrane; protein-containing complex; dendrite; FAR/SIN/STRIPAK complex;
Biological process	biological process;
	Sources:Amigo / QuickGO
Orthologs
	29888
	97387
	ENSG00000090372
	ENSMUSG00000030374
	Q9NRL3
	P58404
	NM_001039877; NM_013403
	NM_001039878; NM_133789
	NP_001034966; NP_037535
	NP_001034967; NP_598550
	Wikidata
View/Edit Human	View/Edit Mouse

Striatin-4 is a protein that in humans is encoded by the STRN4 gene.^[5]^[6]

Interactions

STRN4 has been shown to interact with STK24.^[7]^[8]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000090372 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030374 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Castets F, Rakitina T, Gaillard S, Moqrich A, Mattei MG, Monneron A (Aug 2000). "Zinedin, SG2NA, and striatin are calmodulin-binding, WD repeat proteins principally expressed in the brain". J. Biol. Chem. 275 (26): 19970–7. doi:10.1074/jbc.M909782199. PMID 10748158.
↑ "Entrez Gene: STRN4 striatin, calmodulin binding protein 4".
↑ Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
↑ Goudreault M, D'Ambrosio LM, Kean MJ, Mullin MJ, Larsen BG, Sanchez A, Chaudhry S, Chen GI, Sicheri F, Nesvizhskii AI, Aebersold R, Raught B, Gingras AC (Jan 2009). "A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein". Mol. Cell. Proteomics. 8 (1): 157–71. doi:10.1074/mcp.M800266-MCP200. PMC 2621004. PMID 18782753.

Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
Gaillard S, Bartoli M, Castets F, Monneron A (2001). "Striatin, a calmodulin-dependent scaffolding protein, directly binds caveolin-1". FEBS Lett. 508 (1): 49–52. doi:10.1016/S0014-5793(01)03020-4. PMID 11707266. S2CID 7887096.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000090372 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030374 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10748158-5] Castets F, Rakitina T, Gaillard S, Moqrich A, Mattei MG, Monneron A (Aug 2000). "Zinedin, SG2NA, and striatin are calmodulin-binding, WD repeat proteins principally expressed in the brain". J. Biol. Chem. 275 (26): 19970–7. doi:10.1074/jbc.M909782199. PMID 10748158.

[entrez-6] "Entrez Gene: STRN4 striatin, calmodulin binding protein 4".

[pmid17353931-7] Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

[pmid18782753-8] Goudreault M, D'Ambrosio LM, Kean MJ, Mullin MJ, Larsen BG, Sanchez A, Chaudhry S, Chen GI, Sicheri F, Nesvizhskii AI, Aebersold R, Raught B, Gingras AC (Jan 2009). "A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein". Mol. Cell. Proteomics. 8 (1): 157–71. doi:10.1074/mcp.M800266-MCP200. PMC 2621004. PMID 18782753.

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Interactions

References

Further reading