SMIM11
Identifiers
AliasesSMIM11, C21orf51, FAM165B, small integral membrane protein 11, SMIM11B, SMIM11A, small integral membrane protein 11A
External IDsHomoloGene: 129857 GeneCards: SMIM11
Orthologs
SpeciesHumanMouse
Entrez

54065

n/a

Ensembl

ENSG00000205670

n/a

UniProt

P58511

n/a

RefSeq (mRNA)

NM_058182
NM_001376899

n/a

RefSeq (protein)

NP_478062
NP_001363828

n/a

Location (UCSC)Chr 21: 34.38 – 34.42 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Small integral membrane protein 11 is a protein which in humans is encoded by the SMIM11 gene.[3][4]

Gene

Locus

SMIM11 is located on the plus strand of chromosome 21 and has 4 exons.[4]

Expression of SMIM11A in human tissue samples

Expression

The expression of SMIM11 is highest in the brain, thyroid, and stomach, though it is also expressed in many other tissues.[4]

mRNA

There are no known transcript variants or isoforms of SMIM11.[5]

Protein

The SMIM11 protein is 58 amino acids long. The theoretical molecular weight of this protein is 6kDa and the theoretical pI is 9.[6] The protein is localized in the cytoplasm and mitochondria, as well as focal adhesion points between the cells.[7][8]

Domains, Motifs, and Post-translational Modifications

SMIM11 contains a transmembrane domain.[9] The protein also holds a dileucine motif. Post-translational modifications include ubiquitylation site, as well as two phosphorylated sites, one on a threonine and one on a serine[10][11]

Secondary Structure and Tertiary Structure

The protein is composed mostly of alpha-helices.[12] The N-terminus of SMIM11 sticks out into the extracellular matrix, while the C-terminal end is located within the cytoplasm of the cell.[13]

Tertiary Structure of SMIM11

Quaternary Structure and Protein Interactions

Experimentally-determined protein interactions for SMIM11 have not yet been identified.[14]

Concenptual translation of SMIM11

Homology and Evolution

Paralogs

No paralogs or paralogous domains exist for SMIM11

Orthologs

SMIM11 has a large number of orthologs. These orthologs range from other mammals to birds, reptiles, amphibians, and bony fish.[15]

Ortholog Table of SMIM11

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000205670 - Ensembl, May 2017
  2. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ↑ "P58511 · SIM11_HUMAN". www.uniprot.org. UniProt. Retrieved 2022-12-23.
  4. 1 2 3 "SMIM11 small integral membrane protein 11 [ Homo sapiens (human) ]". ncbi.nlm.nih.gov. National Center for Biotechnology Information, U.S. National Library of Medicine. Retrieved 2022-12-23.
  5. ↑ "SMIM11A Protein Coding". genecards.org.
  6. ↑ "Compute pI/Mw Tool Expasy". expasy.org.
  7. ↑ "PSORT II Server". psort.hgc.jp.
  8. ↑ "Immunohistochemistry of SMIM11A: The Human Protein Atlas". proteinatlas.org.
  9. ↑ "Homo sapiens small integral membrane protein 11A (SMIM11A), mRNA". ncbi.nlm.nih.gov. NCBI (National Center for Biotechnology Information).
  10. ↑ "iPTMnet Report for P58511 (SMIM11A)". research.bioinformatics.udel.edu.
  11. ↑ "NetPhos 3.1 Server". cbs.dtu.dk.
  12. ↑ "Phyre2 Results". sbg.bio.ic.ac.uk.
  13. ↑ "TMHHM Server". cbs.dtu.dk.
  14. ↑ "STRING FAM165B". string-db.org.
  15. ↑ "NCBI Protein Blast". blast.ncbi.nlm.nih.gov.
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