SLAMF8
Identifiers
Aliases	SLAMF8, BLAME, CD353, SBBI42, SLAM family member 8
External IDs	OMIM: 606620 MGI: 1921998 HomoloGene: 10589 GeneCards: SLAMF8
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q23.2 Start 159,826,811 bp[1] End 159,837,492 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 H3 Start 172,409,325 bp[2] End 172,418,135 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in appendix lymph node lower lobe of lung spleen superficial temporal artery amniotic fluid gallbladder rectum right coronary artery upper lobe of lung Top expressed in spleen morula thymus subcutaneous adipose tissue duodenum jejunum lip white adipose tissue esophagus skin of abdomen More reference expression data BioGPS More reference expression data
Gene ontology Molecular function signaling receptor activity identical protein binding Cellular component membrane integral component of membrane cell surface Biological process leukocyte chemotaxis involved in inflammatory response B-1 B cell lineage commitment negative regulation of macrophage chemotaxis regulation of NAD(P)H oxidase activity defense response to bacterium regulation of kinase activity regulation of B cell differentiation negative regulation of respiratory burst involved in inflammatory response negative regulation of monocyte chemotaxis phagosome acidification negative regulation of neutrophil migration negative regulation of dendritic cell chemotaxis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 56833 74748 Ensembl ENSG00000158714 ENSMUSG00000053318 UniProt Q9P0V8 Q9D3G2 RefSeq (mRNA) NM_020125 NM_001330741 NM_029084 RefSeq (protein) NP_001317670 NP_064510 NP_083360 Location (UCSC) Chr 1: 159.83 – 159.84 Mb Chr 1: 172.41 – 172.42 Mb PubMed search [3] [4]
Wikidata
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SLAM family member 8 is a protein that in humans is encoded by the SLAMF8 gene.^[5][6]

Function

This gene encodes a member of the CD2 family of cell surface proteins involved in lymphocyte activation. These proteins are characterized by Ig domains. This protein is expressed in lymphoid tissues, and studies of a similar protein in mouse suggest that it may function during B cell lineage commitment. The gene is found in a region of chromosome 1 containing many CD2 genes.^[6]

References

Further reading