Richard White
Born
Brooklyn, New York
NationalityAmerican
Alma materStuyvesant High School
Rensselaer Polytechnic Institute
Albany Medical College
Occupation(s)Physician, Researcher
Known forZebrafish as a model for cancer
Scientific career
InstitutionsYale New Haven Hospital
Dana Farber Cancer Institute
Memorial Sloan Kettering Cancer Center
University of Oxford

Richard White is an American physician-scientist known for his development of the zebrafish as a model for cancer.[1][2][3] He is a professor of genetics at the University of Oxford and a member of the Ludwig Institute for Cancer Research.[1][4][5][6][7] White is a Fellow of the American Society for Clinical Investigation.[3]

Early life and education

Richard White was born and raised in Brooklyn, New York. In 1989, he graduated from Stuyvesant High School. He pursued a joint B.S./M.D./Ph.D. program at Rensselaer Polytechnic Institute and Albany Medical College.[8]

Career and research

After completing his internship and residency in Internal medicine at Yale-New Haven Hospital, White underwent a medical oncology fellowship at Dana Farber Cancer Institute and Massachusetts General Hospital.[2][8] His postdoctoral research, conducted at Children’s Hospital Boston and Harvard Medical School under the mentorship of Leonard Zon, focused on the transcriptional programs associated with melanoma.[8][6][9][10]

White is credited with the development of the Casper Strain of Zebrafish, known for its optical transparency throughout adulthood, enabling advanced in vivo imaging.[2][1][11]

In 2012, he joined the faculty of Memorial Sloan Kettering Cancer Center and Weill-Cornell Medical College, where he explored the concept of "Oncogenic Competence" using Zebrafish models.[12][13][11] This concept identifies factors beyond DNA mutations that contribute to a cell's ability to form a tumor, including the cell's differentiation state, anatomical position, and interactions within the tumor microenvironment.[14][15][8]

In 2022, White moved to the University of Oxford, continuing his research.

Awards

Personal life

Richard resides in Oxford, UK, with his partner, Theresa Meyer, and their daughter.

Selected publications

  • White, R. M. et al. Transparent adult zebrafish as a tool for in vivo transplantation analysis. Cell Stem Cell 2, 183–189 (2008).
  • White, R. M. et al. DHODH modulates transcriptional elongation in the neural crest and melanoma. Nature 471, 518–522 (2011).
  • White, R., Rose, K. & Zon, L. Zebrafish cancer: the state of the art and the path forward. Nat. Rev. Cancer 13, 624–636 (2013).
  • Kaufman, C. K. et al. A zebrafish melanoma model reveals emergence of neural crest identity during melanoma initiation. Science 351, aad2197 (2016).
  • Kim, I. S. et al. Microenvironment-derived factors driving metastatic plasticity in melanoma. Nat. Commun. 8, 14343 (2017).
  • Zhang, M. et al. Adipocyte-Derived Lipids Mediate Melanoma Progression via FATP Proteins. Cancer Discov. 8, 1006–1025 (2018).
  • Baggiolini, A. et al. Developmental chromatin programs determine oncogenic competence in melanoma. Science 373, eabc1048 (2021).
  • Weiss, J. M. et al. Anatomic position determines oncogenic specificity in melanoma. Nature 604, 354–361 (2022).
  • Tagore, M. et al. GABA regulates electrical activity and tumor initiation in melanoma. Cancer Discov. (2023) doi:10.1158/2159-8290.CD-23-0389.

References

  1. 1 2 3 "Professor Richard White | University of Oxford". www.ox.ac.uk. Retrieved 2023-12-02.
  2. 1 2 3 "Richard White". www.ndm.ox.ac.uk. Retrieved 2023-12-02.
  3. 1 2 3 4 5 "Home". The American Society for Clinical Investigation. Retrieved 2023-12-02.
  4. ↑ "Editors for Cancer Biology". eLife. Retrieved 2023-12-02.
  5. ↑ "Confirmed Speakers | Stem Cell Biology, Cancer Plasticity and Therapeutic Potential | The European Association for Cancer Research". www.eacr.org. Retrieved 2023-12-02.
  6. 1 2 PhD, Neha J. Pancholi (2023-08-09). "Look Who's Talking: How Electrical Communication Drives Melanoma". American Association for Cancer Research (AACR). Retrieved 2023-12-02.
  7. ↑ "Ludwig Cancer Research". Retrieved 2023-12-02.
  8. 1 2 3 4 5 6 7 8 "The Richard White Lab | Sloan Kettering Institute". www.mskcc.org. 2022-03-30. Retrieved 2023-12-02.
  9. ↑ "GABA transfer between skin cells promotes melanoma initiation". News-Medical.net. 2023-08-09. Retrieved 2023-12-02.
  10. ↑ "2018 Archives". NCRI Cancer Conference abstracts. Retrieved 2023-12-02.
  11. 1 2 "Oncology Seminar Series". Lombardi Comprehensive Cancer Center. Retrieved 2023-12-02.
  12. ↑ "2018 NCRI Cancer Conference" (PDF).
  13. ↑ "NMM 2023" (PDF).
  14. ↑ Binet, Romuald; Lambert, Jean-Philippe; Tomkova, Marketa; Tischfield, Samuel; Baggiolini, Arianna; Picaud, Sarah; Sarkar, Sovan; Louphrasitthiphol, Pakavarin; Dias, Diogo; Carreira, Suzanne; Humphrey, Timothy; Fillipakopoulos, Panagis; White, Richard; Goding, Colin R. (2023-04-21). "DNA damage-induced interaction between a lineage addiction oncogenic transcription factor and the MRN complex shapes a tissue-specific DNA Damage Response and cancer predisposition". bioRxiv: The Preprint Server for Biology: 2023.04.21.537819. doi:10.1101/2023.04.21.537819. PMC 10153263. PMID 37131595.
  15. ↑ Adipocytes in the tumor microenvironment: an emerging target for melanoma treatment, retrieved 2023-12-02
  16. ↑ "PRESS RELEASE: The Pershing Square Sohn Cancer Research Alliance Celebrates Its 10th Anniversary; Annual $5.25M Pershing Square Sohn Prize Awarded to Seven Innovators". Pershing Square Foundation. 2023-05-16. Retrieved 2023-12-02.
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.