ROBO3

ROBO3
Identifiers
Aliases	ROBO3, HGPPS, HGPS, RBIG1, RIG1, roundabout guidance receptor 3, HGPPS1
External IDs	OMIM: 608630 MGI: 1343102 HomoloGene: 32119 GeneCards: ROBO3
Gene location (Human)
Chr.	Chromosome 11 (human)
End	124,881,471 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	37,344,542 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; vena cava; ; sural nerve; ; left uterine tube; ; amygdala; ; spleen; ; nucleus accumbens; ; pericardium; ; right adrenal gland; ; right lobe of thyroid gland;
	Top expressed in
	superior frontal gyrus; ; nerve fascicle; ; rhombic lip; ; habenula; ; outer nuclear layer; ; inner nuclear layer; ; secondary oocyte; ; dentate gyrus; ; primary motor cortex; ; morula;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; cell-cell adhesion mediator activity;
Cellular component	integral component of membrane; axon; membrane; plasma membrane;
Biological process	multicellular organism development; chemotaxis; cell differentiation; axon midline choice point recognition; Roundabout signaling pathway; nervous system development; axon guidance; homophilic cell adhesion via plasma membrane adhesion molecules; chemoattraction of axon; dendrite self-avoidance; commissural neuron axon guidance;
	Sources:Amigo / QuickGO
Orthologs
	64221
	19649
	ENSG00000154134
	ENSMUSG00000032128
	Q96MS0
	Q9Z2I4
	NM_022370
	NM_001164767; NM_011248
NP_071765; NP_001357285; NP_001357286; NP_001357287; NP_001357288;
	NP_001357290; NP_001357293; NP_001357295
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Roundabout homolog 3 is a protein that in humans is encoded by the ROBO3 gene.^[5]^[6]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000154134 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032128 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Jen JC, Chan WM, Bosley TM, Wan J, Carr JR, Rub U, Shattuck D, Salamon G, Kudo LC, Ou J, Lin DD, Salih MA, Kansu T, Al Dhalaan H, Al Zayed Z, MacDonald DB, Stigsby B, Plaitakis A, Dretakis EK, Gottlob I, Pieh C, Traboulsi EI, Wang Q, Wang L, Andrews C, Yamada K, Demer JL, Karim S, Alger JR, Geschwind DH, Deller T, Sicotte NL, Nelson SF, Baloh RW, Engle EC (Jun 2004). "Mutations in a human ROBO gene disrupt hindbrain axon pathway crossing and morphogenesis". Science. 304 (5676): 1509–13. Bibcode:2004Sci...304.1509J. doi:10.1126/science.1096437. PMC 1618874. PMID 15105459.
↑ "Entrez Gene: ROBO3 roundabout, axon guidance receptor, homolog 3 (Drosophila)".

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Yuan SS, Cox LA, Dasika GK, Lee EY (1999). "Cloning and functional studies of a novel gene aberrantly expressed in RB-deficient embryos". Dev. Biol. 207 (1): 62–75. doi:10.1006/dbio.1998.9141. PMID 10049565.
Jen J, Coulin CJ, Bosley TM, et al. (2002). "Familial horizontal gaze palsy with progressive scoliosis maps to chromosome 11q23-25". Neurology. 59 (3): 432–5. doi:10.1212/wnl.59.3.432. PMID 12177379. S2CID 32947142.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Bosley TM, Salih MA, Jen JC, et al. (2006). "Neurologic features of horizontal gaze palsy and progressive scoliosis with mutations in ROBO3". Neurology. 64 (7): 1196–203. doi:10.1212/01.WNL.0000156349.01765.2B. PMID 15824346. S2CID 72500917.
Camurri L, Mambetisaeva E, Davies D, et al. (2006). "Evidence for the existence of two Robo3 isoforms with divergent biochemical properties". Mol. Cell. Neurosci. 30 (4): 485–93. doi:10.1016/j.mcn.2005.07.014. PMID 16226035. S2CID 41242127.
Chan WM, Traboulsi EI, Arthur B, et al. (2006). "Horizontal gaze palsy with progressive scoliosis can result from compound heterozygous mutations in ROBO3". J. Med. Genet. 43 (3): e11. doi:10.1136/jmg.2005.035436. PMC 2563249. PMID 16525029.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000154134 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032128 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid15105459-5] Jen JC, Chan WM, Bosley TM, Wan J, Carr JR, Rub U, Shattuck D, Salamon G, Kudo LC, Ou J, Lin DD, Salih MA, Kansu T, Al Dhalaan H, Al Zayed Z, MacDonald DB, Stigsby B, Plaitakis A, Dretakis EK, Gottlob I, Pieh C, Traboulsi EI, Wang Q, Wang L, Andrews C, Yamada K, Demer JL, Karim S, Alger JR, Geschwind DH, Deller T, Sicotte NL, Nelson SF, Baloh RW, Engle EC (Jun 2004). "Mutations in a human ROBO gene disrupt hindbrain axon pathway crossing and morphogenesis". Science. 304 (5676): 1509–13. Bibcode:2004Sci...304.1509J. doi:10.1126/science.1096437. PMC 1618874. PMID 15105459.

[entrez-6] "Entrez Gene: ROBO3 roundabout, axon guidance receptor, homolog 3 (Drosophila)".

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References

Further reading