Paul A. Hargrave
Born1938
Palmyra, New York, United States
Alma materColgate University
University of Minnesota
Known forRhodopsin
Scientific career
FieldsBiochemistry
InstitutionsCalifornia Institute of Technology
Southern Illinois University
University of Florida

Paul Hargrave (born 1938) is an American biochemist whose laboratory work established key features of the structure of rhodopsin.[1][2]

Career

In 1970, Hargrave received a PhD from the University of Minnesota, where he studied with protein chemist Finn Wold. After post-doctoral work under William J. Dreyer at the California Institute of Technology, Hargrave joined the faculty at Southern Illinois University in 1973.[3]

In 1983, Hargrave and colleagues in his laboratory published the full amino acid sequence for rhodopsin, a photoreceptor protein, after having previously published partial sequences.[4][5][6][7] The sequencing of rhodopsin was later described as a "monumental step" toward understanding the structure of rhodopsin.[8][9] At the time, the purification of water-insoluble peptides was a challenge, and the Hargrave lab published several discoveries about how to manage them.[10]

Hargrave came to the University of Florida in 1984 as a Jules and Doris Stein Research to Prevent Blindness Professor[11] and in 1990 was named the Francis N. Bullard Professor and Eminent Scholar of Ophthalmology and Biochemistry at the University of Florida.[12] His work continued to explore the structure of rhodopsin, including developing a topographic model.[13][14] He also pursued further research into the function of rhodopsin, including its role in visual disease such as retinitis pigmentosa and retinoblastoma.[15][16]

In 1985, Hargrave chaired and secured funding for the first FASEB Science Research Conference on Biology and Chemistry of Vision, which has become a biennial conference.[17][18]

Awards

In 2000, he received the Friedenwald Award of the Association for Research in Vision and Ophthalmology, which honors "outstanding research in the basic or clinical sciences as applied to ophthalmology."[19][20]

Selected works

  • Hargrave, P. A., K. P. Hofmann, and U. B. Kaupp. Signal Transduction in Photoreceptor Cells: Proceedings of an International Workshop, Held at the Research Centre Jülich, Jülich, Fed. Rep. of Germany, 8–11 August 1990. Berlin: Springer-Verlag, 1992. ISBN 3540537651 OCLC 24794897
  • Hargrave, P. A. Photoreceptor Cells. San Diego: Academic Press, 1993. ISBN 9780121852795 OCLC 28740269

Personal life

Hargrave is a member of the 50 States Marathon Club, having completed a marathon in every state in the United States.[21]

He is the father of board game designer Elizabeth Hargrave.[22]

References

  1. ↑ American Men and Women of Science: Chemistry. Bowker. 1977. p. 479. ISBN 9780835210119. Retrieved 26 November 2018.
  2. ↑ American men & women of science: Physical and Biological Sciences. Bowker. 1989. p. 501. ISBN 9780835214179. Retrieved 26 November 2018.
  3. ↑ Papermaster, David S. (2001-01-01). "Introducing Paul Hargrave, the 2000 Recipient of the Friedenwald Award". Investigative Ophthalmology & Visual Science. 42 (1): 1–2. ISSN 1552-5783. PMID 11133840.
  4. ↑ Hargrave, P. A. (1977-05-27). "The amino-terminal tryptic peptide of bovine rhodopsin. A glycopeptide containing two sites of oligosaccharide attachment". Biochimica et Biophysica Acta (BBA) - Protein Structure. 492 (1): 83–94. doi:10.1016/0005-2795(77)90216-1. ISSN 0006-3002. PMID 861254.
  5. ↑ Hargrave, Paul A (1982-01-01). et al. "The carboxyl-terminal one-third of bovine rhodopsin: Its structure and function". Vision Research. 22 (12): 1429–1438. doi:10.1016/0042-6989(82)90205-X. ISSN 0042-6989. PMID 7182998. S2CID 1556264.
  6. ↑ Hargrave, P. A.; McDowell, J. H.; Curtis, Donna R.; Wang, Janet K.; Juszczak, Elizabeth; Fong, Shao-Ling; Mohana Rao, J. K.; Argos, P. (1983). "The structure of bovine rhodopsin". Biophysics of Structure and Mechanism. 9 (4): 235–244. doi:10.1007/bf00535659. ISSN 0340-1057. PMID 6342691. S2CID 20407577.
  7. ↑ Hargrave, P. A.; McDowell, J. H.; Feldmann, R. J.; Atkinson, P. H.; Rao, J. K.; Argos, P. (1984). "Rhodopsin's protein and carbohydrate structure: selected aspects". Vision Research. 24 (11): 1487–1499. doi:10.1016/0042-6989(84)90311-0. ISSN 0042-6989. PMID 6533983. S2CID 31984423.
  8. ↑ Dratz, Edward; Hargrave, Paul A (1983-04-01). "The structure of rhodopsin and the rod outer segment disk membrane". Trends in Biochemical Sciences. 8 (4): 128–131. doi:10.1016/0968-0004(83)90235-9. ISSN 0968-0004.
  9. ↑ Palczewski, Krzysztof (February 2011). "Focus on vision: 3 decades of remarkable contributions to biology and medicine". The FASEB Journal. 25 (2): 439–443. doi:10.1096/fj.11-0202ufm. ISSN 0892-6638. PMC 3228347. PMID 21282210.
  10. ↑ Papermaster, David S. (2001-01-01). "Introducing Paul Hargrave, the 2000 Recipient of the Friedenwald Award". Investigative Ophthalmology & Visual Science. 42 (1): 1–2. ISSN 1552-5783. PMID 11133840.
  11. ↑ "News and Comment". Archives of Ophthalmology. 103 (4): 492. 1985-04-01. doi:10.1001/archopht.1985.01050040034012. ISSN 0003-9950.
  12. ↑ "Paul Hargrave, Ph.D. | UFRF Professors". ufrfprofessors.feed.research.ufl.edu. Retrieved 2018-11-16.
  13. ↑ Unger, Vinzenz M.; Hargrave, Paul A.; Baldwin, Joyce M.; Schertler, Gebhard F. X. (September 1997). "Arrangement of rhodopsin transmembrane α-helices". Nature. 389 (6647): 203–206. Bibcode:1997Natur.389..203U. doi:10.1038/38316. ISSN 0028-0836. PMID 9296501. S2CID 205026444.
  14. ↑ Hargrave, Paul A; McDowell, J Hugh (1993-01-01). "Rhodopsin and Phototransduction". International Review of Cytology. 137: 49–97. doi:10.1016/S0074-7696(08)62600-5. ISBN 9780123645388. ISSN 0074-7696. PMID 1478822.
  15. ↑ Deretic, Dusanka; Williams, Andrew H.; Ransom, Nancy; Morel, Valerie; Hargrave, Paul A.; Arendt, Anatol (2005-03-01). "Rhodopsin C terminus, the site of mutations causing retinal disease, regulates trafficking by binding to ADP-ribosylation factor 4 (ARF4)". Proceedings of the National Academy of Sciences. 102 (9): 3301–3306. Bibcode:2005PNAS..102.3301D. doi:10.1073/pnas.0500095102. ISSN 0027-8424. PMC 552909. PMID 15728366.
  16. ↑ Vrabec, Tamara; Arbizo, Violeta; Adamus, Grazyna; McDowell, J Hugh; Hargrave, PA; Donoso, Larry (1989-07-01). "Rod Cell-Specific Antigens in Retinoblastoma". Archives of Ophthalmology. 107 (7): 1061–3. doi:10.1001/archopht.1989.01070020123044. ISSN 0003-9950. PMID 2473730.
  17. ↑ Kefalov, Vladimir J.; Arshavsky, Vadim Y. (June 2014). "FASEB Science Research Conference on Biology and Chemistry of Vision". The FASEB Journal. 28 (6): 2395–2397. doi:10.1096/fj.14-0602ufm. ISSN 0892-6638. PMC 6137602. PMID 24891609.
  18. ↑ Paul, Hargrave. "FASEB Conference: Biology and Chemistry of Vision August 11-16, 1985; Saxton's River, Vermont". Grantome.
  19. ↑ Papermaster, David S. (2001-01-01). "Introducing Paul Hargrave, the 2000 Recipient of the Friedenwald Award". Investigative Ophthalmology & Visual Science. 42 (1): 1–2. ISSN 1552-5783. PMID 11133840.
  20. ↑ "International society honors UF vision scientist". UF Health, University of Florida Health. 2000-06-07. Retrieved 2018-11-17.
  21. ↑ "USA Male Finishers by Date". 50 States Club. Retrieved 2018-11-16.
  22. ↑ @elizhargrave (October 13, 2020). "(Elizabeth Hargrave links to this Wikipedia profile as belonging to her father)" (Tweet) – via Twitter.
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