PTPRH
Identifiers
AliasesPTPRH, R-PTP-H, SAP1, protein tyrosine phosphatase, receptor type H, protein tyrosine phosphatase receptor type H
External IDsOMIM: 602510 MGI: 3026877 HomoloGene: 37693 GeneCards: PTPRH
Orthologs
SpeciesHumanMouse
Entrez

5794

545902

Ensembl

ENSG00000080031

ENSMUSG00000035429

UniProt

Q9HD43

E9Q0N2

RefSeq (mRNA)

NM_001161440
NM_002842

NM_207270

RefSeq (protein)

NP_001154912
NP_002833

NP_997153

Location (UCSC)Chr 19: 55.18 – 55.21 MbChr 7: 4.55 – 4.61 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Receptor-type tyrosine-protein phosphatase H is an enzyme that in humans is encoded by the PTPRH gene.[5][6]

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP. The extracellular region contains eight fibronectin type III-like repeats and multiple N-glycosylation sites. The gene was shown to be expressed primarily in brain and liver, and at a lower level in heart and stomach. It was also found to be expressed in several cancer cell lines, but not in the corresponding normal tissues.[6]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000080031 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000035429 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Matozaki T, Suzuki T, Uchida T, Inazawa J, Ariyama T, Matsuda K, Horita K, Noguchi H, Mizuno H, Sakamoto C, et al. (Feb 1994). "Molecular cloning of a human transmembrane-type protein tyrosine phosphatase and its expression in gastrointestinal cancers". J Biol Chem. 269 (3): 2075–81. doi:10.1016/S0021-9258(17)42137-5. PMID 8294459.
  6. 1 2 "Entrez Gene: PTPRH protein tyrosine phosphatase, receptor type, H".

Further reading


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