PARD3

PARD3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2KOM
Identifiers
Aliases	PARD3, ASIP, Baz, PAR3, PAR3alpha, PARD-3, PARD3A, PPP1R118, SE2-5L16, SE2-5LT1, SE2-5T2, par-3 family cell polarity regulator
External IDs	OMIM: 606745 MGI: 2135608 HomoloGene: 10489 GeneCards: PARD3
Gene location (Human)
Chr.	Chromosome 10 (human)
End	34,815,325 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	128,338,767 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; skin of abdomen; ; nipple; ; Achilles tendon; ; internal globus pallidus; ; gastric mucosa; ; sural nerve; ; gastrocnemius muscle; ; islet of Langerhans; ; vagina;
	Top expressed in
	esophagus; ; lip; ; secondary oocyte; ; conjunctival fornix; ; hand; ; cornea; ; ciliary body; ; skin of abdomen; ; epidermis; ; internal carotid artery;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	phosphatidylinositol-3-phosphate binding; protein binding; phosphatidylinositol-4,5-bisphosphate binding; protein phosphatase binding; phosphatidylinositol-3,4,5-trisphosphate binding; lipid binding; identical protein binding; phosphatidylinositol binding;
Cellular component	cytoplasm; cytosol; membrane; cell-cell junction; bicellular tight junction; plasma membrane; axonal growth cone; internode region of axon; cell junction; neuronal cell body; cell cortex; cytoskeleton; endomembrane system; adherens junction; protein-containing complex; apical plasma membrane; apical junction complex;
Biological process	establishment of epithelial cell polarity; cell differentiation; axonogenesis; protein targeting to membrane; negative regulation of peptidyl-threonine phosphorylation; myelination in peripheral nervous system; cell division; establishment or maintenance of cell polarity; positive regulation of myelination; regulation of cellular localization; protein kinase C-activating G protein-coupled receptor signaling pathway; asymmetric cell division; bicellular tight junction assembly; cell cycle; transforming growth factor beta receptor signaling pathway; protein-containing complex assembly; microtubule cytoskeleton organization; cell adhesion; protein localization; establishment of cell polarity; establishment or maintenance of epithelial cell apical/basal polarity; establishment of centrosome localization;
	Sources:Amigo / QuickGO
Orthologs
	56288
	93742
	ENSG00000148498
	ENSMUSG00000025812
	Q8TEW0
	Q99NH2
NM_001184785; NM_001184786; NM_001184787; NM_001184788; NM_001184789;
	NM_001184790; NM_001184791; NM_001184792; NM_001184793; NM_001184794; NM_019619
NM_001013580; NM_001013581; NM_001122850; NM_033620; NM_001309391;
	NM_001309392; NM_001363431; NM_001363432
NP_001171714; NP_001171715; NP_001171716; NP_001171717; NP_001171718;
	NP_001171719; NP_001171720; NP_001171721; NP_001171722; NP_001171723; NP_062565
NP_001013598; NP_001013599; NP_001116322; NP_001296320; NP_001296321;
	NP_296369; NP_001350360; NP_001350361
	Wikidata
View/Edit Human	View/Edit Mouse

Partitioning defective 3 homolog is a protein that in humans is encoded by the PARD3 gene.^[5]^[6]

Function

PARD proteins, which were first identified in C. elegans, are essential for asymmetric cell division and polarized growth, whereas CDC42 (MIM 116952) mediates the establishment of cell polarity. The CDC42 GTPase, which is controlled by nucleotide exchange factors (GEFs; see MIM 606057) and GTPase-activating proteins (GAPs; see MIM 604980), interacts with a large set of effector proteins that typically contain a CDC42/RAC (MIM 602048)-interactive binding (CRIB) domain.[supplied by OMIM]^[6]

Interactions

PARD3 has been shown to interact with:

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000148498 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025812 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Joberty G, Petersen C, Gao L, Macara IG (Oct 2000). "The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42". Nat Cell Biol. 2 (8): 531–9. doi:10.1038/35019573. PMID 10934474. S2CID 27139234.
1 2 "Entrez Gene: PARD3 par-3 partitioning defective 3 homolog (C. elegans)".
1 2 Ebnet K, Aurrand-Lions M, Kuhn A, Kiefer F, Butz S, Zander K, Meyer zu Brickwedde MK, Suzuki A, Imhof BA, Vestweber D (Oct 2003). "The junctional adhesion molecule (JAM) family members JAM-2 and JAM-3 associate with the cell polarity protein PAR-3: a possible role for JAMs in endothelial cell polarity". J. Cell Sci. 116 (Pt 19): 3879–91. doi:10.1242/jcs.00704. PMID 12953056.
↑ Kohjima M, Noda Y, Takeya R, Saito N, Takeuchi K, Sumimoto H (Dec 2002). "PAR3beta, a novel homologue of the cell polarity protein PAR3, localizes to tight junctions". Biochem. Biophys. Res. Commun. 299 (4): 641–6. doi:10.1016/s0006-291x(02)02698-0. PMID 12459187.
↑ Takekuni K, Ikeda W, Fujito T, Morimoto K, Takeuchi M, Monden M, Takai Y (Feb 2003). "Direct binding of cell polarity protein PAR-3 to cell-cell adhesion molecule nectin at neuroepithelial cells of developing mouse". J. Biol. Chem. 278 (8): 5497–500. doi:10.1074/jbc.C200707200. PMID 12515806.

Johansson A, Driessens M, Aspenström P (2000). "The mammalian homologue of the Caenorhabditis elegans polarity protein PAR-6 is a binding partner for the Rho GTPases Cdc42 and Rac1". J. Cell Sci. 113 (18): 3267–75. doi:10.1242/jcs.113.18.3267. PMID 10954424.
Eichmuller S, Usener D, Dummer R, Stein A, Thiel D, Schadendorf D (2001). "Serological detection of cutaneous T-cell lymphoma-associated antigens". Proc. Natl. Acad. Sci. U.S.A. 98 (2): 629–34. doi:10.1073/pnas.021386498. PMC 14639. PMID 11149944.
Suzuki A, Yamanaka T, Hirose T, Manabe N, Mizuno K, Shimizu M, Akimoto K, Izumi Y, Ohnishi T, Ohno S (2001). "Atypical protein kinase C is involved in the evolutionarily conserved par protein complex and plays a critical role in establishing epithelia-specific junctional structures". J. Cell Biol. 152 (6): 1183–96. doi:10.1083/jcb.152.6.1183. PMC 2199212. PMID 11257119.
Noda Y, Takeya R, Ohno S, Naito S, Ito T, Sumimoto H (2001). "Human homologues of the Caenorhabditis elegans cell polarity protein PAR6 as an adaptor that links the small GTPases Rac and Cdc42 to atypical protein kinase C." Genes Cells. 6 (2): 107–19. doi:10.1046/j.1365-2443.2001.00404.x. PMID 11260256. S2CID 8789941.
Ebnet K, Suzuki A, Horikoshi Y, Hirose T, Meyer Zu Brickwedde MK, Ohno S, Vestweber D (2001). "The cell polarity protein ASIP/PAR-3 directly associates with junctional adhesion molecule (JAM)". EMBO J. 20 (14): 3738–48. doi:10.1093/emboj/20.14.3738. PMC 125258. PMID 11447115.
Fang CM, Xu YH (2002). "Down-regulated expression of atypical PKC-binding domain deleted asip isoforms in human hepatocellular carcinomas". Cell Res. 11 (3): 223–9. doi:10.1038/sj.cr.7290090. PMID 11642408.
Gao L, Macara IG, Joberty G (2003). "Multiple splice variants of Par3 and of a novel related gene, Par3L, produce proteins with different binding properties". Gene. 294 (1–2): 99–107. doi:10.1016/S0378-1119(02)00681-9. PMID 12234671.
Kohjima M, Noda Y, Takeya R, Saito N, Takeuchi K, Sumimoto H (2003). "PAR3beta, a novel homologue of the cell polarity protein PAR3, localizes to tight junctions". Biochem. Biophys. Res. Commun. 299 (4): 641–6. doi:10.1016/S0006-291X(02)02698-0. PMID 12459187.
Takekuni K, Ikeda W, Fujito T, Morimoto K, Takeuchi M, Monden M, Takai Y (2003). "Direct binding of cell polarity protein PAR-3 to cell-cell adhesion molecule nectin at neuroepithelial cells of developing mouse". J. Biol. Chem. 278 (8): 5497–500. doi:10.1074/jbc.C200707200. PMID 12515806.
Warner DR, Pisano MM, Roberts EA, Greene RM (2003). "Identification of three novel Smad binding proteins involved in cell polarity". FEBS Lett. 539 (1–3): 167–73. doi:10.1016/S0014-5793(03)00155-8. PMID 12650946.
Brajenovic M, Joberty G, Küster B, Bouwmeester T, Drewes G (2004). "Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network". J. Biol. Chem. 279 (13): 12804–11. doi:10.1074/jbc.M312171200. PMID 14676191.
Navarro-Lérida I, Martínez Moreno M, Roncal F, Gavilanes F, Albar JP, Rodríguez-Crespo I (2004). "Proteomic identification of brain proteins that interact with dynein light chain LC8". Proteomics. 4 (2): 339–46. doi:10.1002/pmic.200300528. PMID 14760703. S2CID 8868600.
Brill LM, Salomon AR, Ficarro SB, Mukherji M, Stettler-Gill M, Peters EC (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Anal. Chem. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186.
Liu XF, Ishida H, Raziuddin R, Miki T (2004). "Nucleotide exchange factor ECT2 interacts with the polarity protein complex Par6/Par3/protein kinase Czeta (PKCzeta) and regulates PKCzeta activity". Mol. Cell. Biol. 24 (15): 6665–75. doi:10.1128/MCB.24.15.6665-6675.2004. PMC 444862. PMID 15254234.
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, Metalnikov P, O'Donnell P, Taylor P, Taylor L, Zougman A, Woodgett JR, Langeberg LK, Scott JD, Pawson T (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000148498 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025812 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10934474-5] Joberty G, Petersen C, Gao L, Macara IG (Oct 2000). "The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42". Nat Cell Biol. 2 (8): 531–9. doi:10.1038/35019573. PMID 10934474. S2CID 27139234.

[entrez-6] 1 2 "Entrez Gene: PARD3 par-3 partitioning defective 3 homolog (C. elegans)".

[pmid12953056-7] 1 2 Ebnet K, Aurrand-Lions M, Kuhn A, Kiefer F, Butz S, Zander K, Meyer zu Brickwedde MK, Suzuki A, Imhof BA, Vestweber D (Oct 2003). "The junctional adhesion molecule (JAM) family members JAM-2 and JAM-3 associate with the cell polarity protein PAR-3: a possible role for JAMs in endothelial cell polarity". J. Cell Sci. 116 (Pt 19): 3879–91. doi:10.1242/jcs.00704. PMID 12953056.

[pmid12459187-8] Kohjima M, Noda Y, Takeya R, Saito N, Takeuchi K, Sumimoto H (Dec 2002). "PAR3beta, a novel homologue of the cell polarity protein PAR3, localizes to tight junctions". Biochem. Biophys. Res. Commun. 299 (4): 641–6. doi:10.1016/s0006-291x(02)02698-0. PMID 12459187.

[pmid12515806-9] Takekuni K, Ikeda W, Fujito T, Morimoto K, Takeuchi M, Monden M, Takai Y (Feb 2003). "Direct binding of cell polarity protein PAR-3 to cell-cell adhesion molecule nectin at neuroepithelial cells of developing mouse". J. Biol. Chem. 278 (8): 5497–500. doi:10.1074/jbc.C200707200. PMID 12515806.

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Function

Interactions

References

Further reading