OS9
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesOS9, ERLEC2, OS-9, endoplasmic reticulum lectin, OS9 endoplasmic reticulum lectin
External IDsOMIM: 609677 MGI: 1924301 HomoloGene: 31409 GeneCards: OS9
Orthologs
SpeciesHumanMouse
Entrez

10956

216440

Ensembl

ENSG00000135506

ENSMUSG00000040462

UniProt

Q13438

Q8K2C7

RefSeq (mRNA)

NM_001171026
NM_177614

RefSeq (protein)

NP_001164497
NP_808282

Location (UCSC)Chr 12: 57.69 – 57.72 MbChr 10: 126.93 – 126.96 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Protein OS-9 is a protein that in humans is encoded by the OS9 gene.[5][6][7][8][9]

Function

This gene encodes a protein that is highly expressed in osteosarcomas. This protein binds to the hypoxia-inducible factor 1 (HIF-1), a key regulator of the hypoxic response and angiogenesis, and promotes the degradation of one of its subunits. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[9]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000135506 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000040462 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Su YA, Hutter CM, Trent JM, Meltzer PS (Apr 1996). "Complete sequence analysis of a gene (OS-9) ubiquitously expressed in human tissues and amplified in sarcomas". Molecular Carcinogenesis. 15 (4): 270–5. doi:10.1002/(SICI)1098-2744(199604)15:4<270::AID-MC4>3.0.CO;2-K. PMID 8634085. S2CID 23490951.
  6. Kimura Y, Nakazawa M, Tsuchiya N, Asakawa S, Shimizu N, Yamada M (Dec 1997). "Genomic organization of the OS-9 gene amplified in human sarcomas". Journal of Biochemistry. 122 (6): 1190–5. doi:10.1093/oxfordjournals.jbchem.a021880. PMID 9498564.
  7. Hosokawa N, Kamiya Y, Kamiya D, Kato K, Nagata K (Jun 2009). "Human OS-9, a lectin required for glycoprotein endoplasmic reticulum-associated degradation, recognizes mannose-trimmed N-glycans". The Journal of Biological Chemistry. 284 (25): 17061–8. doi:10.1074/jbc.M809725200. PMC 2719344. PMID 19346256.
  8. Christianson JC, Shaler TA, Tyler RE, Kopito RR (Mar 2008). "OS-9 and GRP94 deliver mutant alpha1-antitrypsin to the Hrd1-SEL1L ubiquitin ligase complex for ERAD". Nature Cell Biology. 10 (3): 272–82. doi:10.1038/ncb1689. PMC 2757077. PMID 18264092.
  9. 1 2 "Entrez Gene: OS9 amplified in osteosarcoma".

Further reading

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