Nonidet P-40 is a nonionic, non-denaturing detergent. Its official IUPAC name is octylphenoxypolyethoxyethanol.

Nonidet P-40 is sometimes abbreviated as NP-40, but should not be confused with a different detergent by the same name NP-40, nonylphenoxypolyethoxyethanol of the Tergitol NP series of Dow Chemicals.

Nonidet was a trademark of Shell Chemical Co. from 1956 to the early 2000s,[1][2] but they no longer make it.[3]

Nonidet P-40 is no longer sold by the chemical company Sigma-Aldrich. Sigma-Aldrich has replaced Nonidet P-40 with IGEPAL CA-630, which is described as a "nonionic, non-denaturing detergent". Sigma-Aldrich claims that IGEPAL CA-630 is "chemically indistinguishable from Nonidet P-40".

IGEPAL consists of octyl-phenoxy(polyoxyethylene)ethanol. Tergitol and the Sigma and BioChemica Nonidet P40 substitute detergents consist of nonyl-phenyl-polyethylene glycol. The original Shell Nonidet P-40 consisted of octyl-phenoxy(polyoxyethylene)ethanol, making IGEPAL the most comparable of the four substitutes.[3]

References

  1. ↑ "Search Results: Nonidet". Australian Trade Mark Search. IP Australia. Retrieved 5 February 2023.
  2. ↑ "Trade mark number UK00000754161". Intellectual Property Office. The Crown (UK). Retrieved 5 February 2023.
  3. 1 2 Saptarshi Sinha; Jessica Field; John H. Miller (June 2017). "Use of substitute Nonidet P-40 nonionic detergents in intraellular tubulin polymerization assays for screening of microtubulte targeting agents". Biochemistry and Cell Biology. 95 (3): 379–384. doi:10.1139/bcb-2016-0141. ISSN 0829-8211. PMID 28177759. S2CID 207087225.


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