Naphthomycins are a group of closely related antimicrobial chemical compounds isolated from Streptomyces. They are considered a subclass of ansamycins.

Members include:

  • Naphthomycin A[1][2]
  • Naphthomycin B[3]
  • Naphthomycin C[3]
  • Naphthomycin D
  • Naphthomycin E
  • Naphthomycin F
  • Naphthomycin G
  • Naphthomycin H[4]
  • Naphthomycin I[5]
  • Naphthomycin J[5]
  • Naphthomycin K[6]
  • Naphthomycin L[7]
  • Naphthomycin M[7]
  • Naphthomycin N[7]

Chemical structures

References

  1. ↑ Balerna, M.; Keller-Schierlein, W.; Martius, C.; Wolf, H.; Zähner, H. (1969). "Metabolic products of microorganisms. 72. Naphthomycin, an antimetabolite of vitamin K". Arch. Mikrobiol. 65 (4): 303–17. doi:10.1007/BF00412210. PMID 4988744. S2CID 31145406.
  2. ↑ Williams, TH (1975). "Naphthomycin, a novel ansa macrocyclic metabolite. Proton NMR spectra and structural elucidation using lanthanide shift reagent". J Antibiot. 28 (1): 85–86. doi:10.7164/antibiotics.28.85. PMID 805115.
  3. 1 2 Keller-Schierlein, W; Meyer, M; Zeeck, A; Damberg, M; Machinek, R; Zähner, H; Lazar, G (1983). "Isolation and structural elucidation of naphthomycins B and C". The Journal of Antibiotics. 36 (5): 484–92. doi:10.7164/antibiotics.36.484. PMID 6874565.
  4. ↑ Mukhopadhyay, T; Franco, CM; Reddy, GC; Ganguli, BN; Fehlhaber, HW (1985). "A new ansamycin antibiotic, naphthomycin H from a Streptomyces species Y-83,40369". The Journal of Antibiotics. 38 (7): 948–51. doi:10.7164/antibiotics.38.948. PMID 4030505.
  5. 1 2 Hooper, AM; Rickards, RW (1998). "3-amino-5-hydroxybenzoic acid in antibiotic biosynthesis. XI. Biological origins and semisynthesis of thionaphthomycins, and the structures of naphthomycins I and J". The Journal of Antibiotics. 51 (9): 845–51. doi:10.7164/antibiotics.51.845. PMID 9820235.
  6. ↑ Lu, Chunhua; Shen, Yuemao (2007). "A Novel Ansamycin, Naphthomycin K from Streptomyces sp". The Journal of Antibiotics. 60 (10): 649–53. doi:10.1038/ja.2007.84. PMID 17965482.
  7. 1 2 3 Yang, YH; Fu, XL; Li, LQ; Zeng, Y; Li, CY; He, YN; Zhao, PJ (2012). "Naphthomycins L-N, ansamycin antibiotics from Streptomyces sp. CS". Journal of Natural Products. 75 (7): 1409–13. doi:10.1021/np300109s. PMID 22742732.
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