Nanoprobe Composition

Nanoprobe at the Advanced Photon Source, Argonne National Laboratory.

A nanoprobe is an optical device developed by tapering an optical fiber to a tip measuring 100 nm = 1000 angstroms wide.

Raman scattering: The reflection of light from a laser-lit object.

A very thin coating of silver nanoparticles helps to enhance the Raman scattering effect of the light. (The phenomenon of light reflection from an object when illuminated by a laser light is referred to as Raman scattering.) The reflected light demonstrates vibration energies unique to each object (samples in this case), which can be characterised and identified.

Silver nanoparticles

The silver nanoparticles in this technique provides for the rapid oscillations of electrons, adding to vibration energies, and thus enhancing Raman Scattering—commonly known as surface-enhanced Raman scattering (SERS). These SERS nanoprobes produce higher electromagnetic fields enabling higher signal output—eventually resulting in accurate detection and analysis of samples.

Enhanced signal output

The term nanoprobe also refers more generically to any chemical or biological technique that deals with nanoquantitles, that is, introducing or extracting substances measured in nanoliters or nanograms rather than microliters or micrograms. For example:

  • Introducing nanoparticles in aqueous solution to serve as nanoprobes in electrospray ionization mass spectrometry[1]
  • Extracting nanoquantities of neurochemicals via in vivo microdialysis[2]
  • Using gold-based metallic nanoprobes for Theranostics (therapeutic diagnostics)[3]

In semiconductor manufacturing, nanoprobing is showing potential for conventional IC failure analysis and debugging, as well as for transistor design, circuit, and process development, and even for yield engineering.[4]

Use of nanoprobe in the detection of diabetes

Nanotechnology solutions can be used in the diagnosis and early treatment of diabetes. There are two types of diabetes: type 1[5] and type 2.[6] Regular checking of blood glucose involves a painful mechanism by piercing the finger. Still, New nanotechnology innovations have made it possible to check blood sugar non-invasively, leading to the early detection of diabetes.[7] Nanoprobe devices have improved the insulin monitoring system, which is necessary for diabetes management, gene therapy and Islet cell screening, pre-transplantation.[8]

See also

References

  1. ↑ Wu, Hui-Fen; Agrawal, Kavita; Shrivas, Kamlesh; Lee, Yi-Hsien (2010). "On particle ionization/enrichment of multifunctional nanoprobes: Washing/separation-free, acceleration and enrichment of microwave-assisted tryptic digestion of proteins via bare TiO2 nanoparticles in ESI-MS and comparing to MALDI-MS". Journal of Mass Spectrometry. 45 (12): 1402–8. Bibcode:2010JMSp...45.1402W. doi:10.1002/jms.1855. PMID 20967754.
  2. ↑ Khandelwal, Purnima; Beyer, Chad E.; Lin, Qian; Schechter, Lee E.; Bach, Alvin C. (2004). "Studying Rat Brain Neurochemistry Using Nanoprobe NMR Spectroscopy: A Metabonomics Approach". Analytical Chemistry. 76 (14): 4123–7. doi:10.1021/ac049812u. PMID 15253652.
  3. ↑ Panchapakesan, Balaji; Book-Newell, Brittany; Sethu, Palaniappan; Rao, Madhusudhana; Irudayaraj, Joseph (2011). "Gold nanoprobes for theranostics". Nanomedicine. 6 (10): 1787–811. doi:10.2217/nnm.11.155. PMC 3236610. PMID 22122586.
  4. ↑ Ukraintsev, V. (2014). "Modern trends in processing, metrology, and control for integrated circuits". SPIE Newsroom. doi:10.1117/2.1201312.005247.
  5. ↑ "Type 1 vs Type 2 Diabetes | UVA Health". uvahealth.com. Retrieved 2023-11-30.
  6. ↑ "Type 1 vs Type 2 Diabetes | UVA Health". uvahealth.com. Retrieved 2023-11-30.
  7. ↑ Lemmerman, Luke; Das, Devleena; Higuita-Castro, Natalia; Mirmira, Raghavendra G; Gallego-Perez, Daniel (June 2020). "Nanomedicine-based Strategies for Diabetes: Diagnostics, Monitoring and Treatment". Trends in Endocrinology and Metabolism. 31 (6): 448–458. doi:10.1016/j.tem.2020.02.001. ISSN 1043-2760. PMC 7987328. PMID 32396845.
  8. ↑ Lemmerman, Luke; Das, Devleena; Higuita-Castro, Natalia; Mirmira, Raghavendra G; Gallego-Perez, Daniel (June 2020). "Nanomedicine-based Strategies for Diabetes: Diagnostics, Monitoring and Treatment". Trends in Endocrinology and Metabolism. 31 (6): 448–458. doi:10.1016/j.tem.2020.02.001. ISSN 1043-2760. PMC 7987328. PMID 32396845.


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