NDST1

NDST1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1NST
Identifiers
Aliases	NDST1, HSST, NST1, MRT46, N-deacetylase/N-sulfotransferase 1, N-deacetylase and N-sulfotransferase 1
External IDs	OMIM: 600853 MGI: 104719 HomoloGene: 20386 GeneCards: NDST1
Gene location (Human)
Chr.	Chromosome 5 (human)
End	150,558,211 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	60,881,722 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; olfactory bulb; ; subthalamic nucleus; ; inferior ganglion of vagus nerve; ; right lobe of liver; ; inferior olivary nucleus; ; upper lobe of left lung; ; external globus pallidus; ; spleen; ; ventral tegmental area;
	Top expressed in
	right lung lobe; ; left lung; ; left lung lobe; ; lacrimal gland; ; epithelium of stomach; ; left lobe of liver; ; salivary gland; ; vas deferens; ; digastric muscle; ; maxillary prominence;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; sulfotransferase activity; deacetylase activity; catalytic activity; hydrolase activity; N-acetylglucosamine deacetylase activity; protein binding; [heparan sulfate-glucosamine N-sulfotransferase activity]; heparan sulfate N-acetylglucosaminyltransferase activity; heparan sulfate sulfotransferase activity;
Cellular component	integral component of membrane; Golgi apparatus; membrane; Golgi membrane;
Biological process	cardiac septum development; heparin biosynthetic process; embryonic neurocranium morphogenesis; coronary vasculature development; respiratory gaseous exchange by respiratory system; fibroblast growth factor receptor signaling pathway; aorta development; heart development; glycosaminoglycan biosynthetic process; animal organ morphogenesis; embryonic viscerocranium morphogenesis; polysaccharide biosynthetic process; forebrain development; metabolism; protein sulfation; inflammatory response; midbrain development; glycosaminoglycan metabolic process; heparan sulfate proteoglycan biosynthetic process; heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process; positive regulation of MAPK cascade; positive regulation of smoothened signaling pathway; sulfur compound metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	3340
	15531
	ENSG00000070614
	ENSMUSG00000054008
	P52848
	Q3UHN9
	NM_001301063; NM_001543
NM_008306; NM_001348100; NM_001348101; NM_001348102; NM_001348103;
	NM_001348146
	NP_001287992; NP_001534
NP_032332; NP_001335029; NP_001335030; NP_001335031; NP_001335032;
	NP_001335075
	Wikidata
View/Edit Human	View/Edit Mouse

Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 is an enzyme. In humans, it is encoded by the NDST1 gene.^[5]^[6]^[7]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000070614 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000054008 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Dixon J, Loftus SK, Gladwin AJ, Scambler PJ, Wasmuth JJ, Dixon MJ (Aug 1995). "Cloning of the human heparan sulfate-N-deacetylase/N-sulfotransferase gene from the Treacher Collins syndrome candidate region at 5q32-q33.1". Genomics. 26 (2): 239–44. doi:10.1016/0888-7543(95)80206-2. PMID 7601448.
↑ Humphries DE, Sullivan BM, Aleixo MD, Stow JL (Aug 1997). "Localization of human heparan glucosaminyl N-deacetylase/N-sulphotransferase to the trans-Golgi network". Biochem J. 325. ( Pt 2) (2): 351–7. doi:10.1042/bj3250351. PMC 1218567. PMID 9230113.
↑ "Entrez Gene: NDST1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1".

Sueyoshi T, Kakuta Y, Pedersen LC, et al. (1998). "A role of Lys614 in the sulfotransferase activity of human heparan sulfate N-deacetylase/N-sulfotransferase". FEBS Lett. 433 (3): 211–4. doi:10.1016/S0014-5793(98)00913-2. PMID 9744796. S2CID 9055616.
Aikawa J, Esko JD (1999). "Molecular cloning and expression of a third member of the heparan sulfate/heparin GlcNAc N-deacetylase/ N-sulfotransferase family". J. Biol. Chem. 274 (5): 2690–5. doi:10.1074/jbc.274.5.2690. PMID 9915799.
Kakuta Y, Sueyoshi T, Negishi M, Pedersen LC (1999). "Crystal structure of the sulfotransferase domain of human heparan sulfate N-deacetylase/ N-sulfotransferase 1". J. Biol. Chem. 274 (16): 10673–6. doi:10.1074/jbc.274.16.10673. PMID 10196134.
Pikas DS, Eriksson I, Kjellén L (2000). "Overexpression of different isoforms of glucosaminyl N-deacetylase/N-sulfotransferase results in distinct heparan sulfate N-sulfation patterns". Biochemistry. 39 (15): 4552–8. doi:10.1021/bi992524l. PMID 10758005.
Mura CV, Becker MI, Orellana A, Wolff D (2002). "Immunopurification of Golgi vesicles by magnetic sorting". J. Immunol. Methods. 260 (1–2): 263–71. doi:10.1016/S0022-1759(01)00546-4. PMID 11792394.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Bengtsson J, Eriksson I, Kjellén L (2003). "Distinct effects on heparan sulfate structure by different active site mutations in NDST-1". Biochemistry. 42 (7): 2110–5. doi:10.1021/bi026928g. PMID 12590599.
van den Born J, Pikas DS, Pisa BJ, et al. (2003). "Antibody-based assay for N-deacetylase activity of heparan sulfate/heparin N-deacetylase/N-sulfotransferase (NDST): novel characteristics of NDST-1 and -2". Glycobiology. 13 (1): 1–10. doi:10.1093/glycob/cwg011. PMID 12634318.
Nakayama K, Natori Y, Sato T, et al. (2004). "Altered expression of NDST-1 messenger RNA in puromycin aminonucleoside nephrosis". J. Lab. Clin. Med. 143 (2): 106–14. doi:10.1016/j.lab.2003.10.012. PMID 14966466.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000070614 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000054008 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7601448-5] Dixon J, Loftus SK, Gladwin AJ, Scambler PJ, Wasmuth JJ, Dixon MJ (Aug 1995). "Cloning of the human heparan sulfate-N-deacetylase/N-sulfotransferase gene from the Treacher Collins syndrome candidate region at 5q32-q33.1". Genomics. 26 (2): 239–44. doi:10.1016/0888-7543(95)80206-2. PMID 7601448.

[pmid9230113-6] Humphries DE, Sullivan BM, Aleixo MD, Stow JL (Aug 1997). "Localization of human heparan glucosaminyl N-deacetylase/N-sulphotransferase to the trans-Golgi network". Biochem J. 325. ( Pt 2) (2): 351–7. doi:10.1042/bj3250351. PMC 1218567. PMID 9230113.

[entrez-7] "Entrez Gene: NDST1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1".

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References

Further reading