N-acetyltransferase 2

NAT2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2PFR
Identifiers
Aliases	NAT2, AAC2, NAT-2, PNAT, N-acetyltransferase 2, N-acetyltransferase 2 (arylamine N-acetyltransferase)
External IDs	OMIM: 612182 MGI: 97279 HomoloGene: 115468 GeneCards: NAT2
Gene location (Human)
Chr.	Chromosome 8 (human)
End	18,401,218 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	67,944,756 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; jejunal mucosa; ; duodenum; ; rectum; ; amniotic fluid; ; appendix; ; smooth muscle tissue; ; secondary oocyte; ; placenta; ; spleen;
	Top expressed in
	pineal gland; ; blastocyst; ; respiratory epithelium; ; olfactory epithelium; ; morula; ; gastrocnemius muscle; ; liver; ; superior frontal gyrus; ; hippocampus proper; ; anterior horn of spinal cord;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	arylamine N-acetyltransferase activity; transferase activity; acetyltransferase activity; acyltransferase activity; protein binding; N-acetyltransferase activity;
Cellular component	cytoplasm; cytosol;
Biological process	xenobiotic metabolic process; metabolism;
	Sources:Amigo / QuickGO
Orthologs
	10
	17960
	ENSG00000156006
	ENSMUSG00000025588
	P11245
	P50294
	NM_000015
	NM_008673
	NP_000006
	NP_032699
	Wikidata
View/Edit Human	View/Edit Mouse

N-acetyltransferase 2 (arylamine N-acetyltransferase), also known as NAT2, is an enzyme which in humans is encoded by the NAT2 gene.^[5]

Function

This gene encodes a type of N-acetyltransferase. The NAT2 isozyme functions to both activate and deactivate arylamine and hydrazine drugs and carcinogens. Polymorphisms in this gene are responsible for the N-acetylation polymorphism in which human populations segregate into rapid, intermediate, and slow acetylator phenotypes. Polymorphisms in NAT2 are also associated with higher incidences of cancer and drug toxicity. A second arylamine N-acetyltransferase gene (NAT1) is located near NAT2.^[6]

Phenotype prediction

The NAT2 acetylator phenotype can be inferred from NAT2 genotype (a combination of SNPs observed in a given individual).^[7]^[8]^[9]^[10]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000156006 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025588 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Vatsis KP, Weber WW, Bell DA, Dupret JM, Evans DA, Grant DM, Hein DW, Lin HJ, Meyer UA, Relling MV, Sim E, Suzuki T, Yamazoe Y (February 1995). "Nomenclature for N-acetyltransferases". Pharmacogenetics. 5 (1): 1–17. doi:10.1097/00008571-199502000-00001. PMID 7773298.
↑ "Entrez Gene: NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase)".
↑ "NAT2PRED: a computational predictor of the human N-AcetylTransferase-2 (NAT2) acetylator phenotype". State University of New York – Albany. Archived from the original on 2009-05-22. Retrieved 2009-04-30.
↑ Kuznetsov IB, McDuffie M, Moslehi R (May 2009). "A web server for inferring the human N-acetyltransferase-2 (NAT2) enzymatic phenotype from NAT2 genotype". Bioinformatics. 25 (9): 1185–6. doi:10.1093/bioinformatics/btp121. PMC 2672629. PMID 19261719.
↑ Agúndez JA (2008). "Polymorphisms of human N-acetyltransferases and cancer risk". Curr. Drug Metab. 9 (6): 520–31. doi:10.2174/138920008784892083. PMID 18680472.
↑ Agúndez JA (2008). "N-acetyltransferases: lessons learned from eighty years of research". Curr. Drug Metab. 9 (6): 463–4. doi:10.2174/138920008784892146. PMID 18680465.

External links

NAT2 human gene location in the UCSC Genome Browser.
NAT2 human gene details in the UCSC Genome Browser.
The Arylamine N-acetyltransferase Gene Nomenclature Committee homepage
PDBe-KB provides an overview of all the structure information available in the PDB for Human Arylamine N-acetyltransferase 2

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000156006 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025588 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7773298-5] Vatsis KP, Weber WW, Bell DA, Dupret JM, Evans DA, Grant DM, Hein DW, Lin HJ, Meyer UA, Relling MV, Sim E, Suzuki T, Yamazoe Y (February 1995). "Nomenclature for N-acetyltransferases". Pharmacogenetics. 5 (1): 1–17. doi:10.1097/00008571-199502000-00001. PMID 7773298.

[6] "Entrez Gene: NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase)".

[urlNAT2PRED:_a_computational_predictor_of_the_human_N-AcetylTransferase-2_(NAT2)_acetylator_phenotype-7] "NAT2PRED: a computational predictor of the human N-AcetylTransferase-2 (NAT2) acetylator phenotype". State University of New York – Albany. Archived from the original on 2009-05-22. Retrieved 2009-04-30.

[pmid19261719-8] Kuznetsov IB, McDuffie M, Moslehi R (May 2009). "A web server for inferring the human N-acetyltransferase-2 (NAT2) enzymatic phenotype from NAT2 genotype". Bioinformatics. 25 (9): 1185–6. doi:10.1093/bioinformatics/btp121. PMC 2672629. PMID 19261719.

[pmid18680472-9] Agúndez JA (2008). "Polymorphisms of human N-acetyltransferases and cancer risk". Curr. Drug Metab. 9 (6): 520–31. doi:10.2174/138920008784892083. PMID 18680472.

[pmid18680465-10] Agúndez JA (2008). "N-acetyltransferases: lessons learned from eighty years of research". Curr. Drug Metab. 9 (6): 463–4. doi:10.2174/138920008784892146. PMID 18680465.

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Function

Phenotype prediction

References

Further reading

External links