Muhammad Imran Qadir
Born (1978-09-03) September 3, 1978
Shujabad, Multan, Pakistan
Alma materBahauddin Zakariya University, Multan
Quaid-i-Azam University, Islamabad
Known forCancer diagnostic test (Qadir test), Anti-HIV drug (Qadirvirtide), a theory of cancer etiology (Qadir theory), Drug for corona (QadirVID-19)
AwardsBest Young Research Scholar and PAS-Gold Medal
Scientific career
FieldsMolecular Biology, Biochemistry
InstitutionsBahauddin Zakariya University
Doctoral advisorDr. Salman A. Malik

Muhammad Imran Qadir (Urdu: محمد عمران قادر; born September 3, 1978), also known as M. I. Qadir, is a Pakistani pharmaceutical scientist.[1][2][3][4]

Life and education

Qadir received his early education from Shujabad, Multan. He received his B.Pharm degree from Bahauddin Zakariya University, Multan, Pakistan. Later he attended Quaid-i-Azam University, Islamabad and received his Ph.D degree in subject of Biochemistry and Molecular Biology.[5][6]

He worked in the College of Pharmacy, Government College University (Faisalabad).[7]

He then became a researcher and professor (associate) at Bahauddin Zakariya University, Multan, Pakistan.[8] There, he is heading "Phage Therapy & Drug Design Laboratory" of Institute of Molecular Biology and Biotechnology.[9]

Research contributions

  1. Qadir test: Qadir invented a medical test, known as the Qadir test, for diagnosis of cancer.[6][10] The approach takes a few hours using standard laboratory equipment for the analysis of plasma lipids (triglycerides, cholesterol, LDL-cholesterol and HDL-cholesterol) and a change in the lipid profile is used as marker for diagnosis of cancer. A number of prospective studies were carried out by the researcher by taking fasting blood samples of study subjects from all the major four types of cancers: carcinomas, sarcomas, lymphomas, and leukemias.[11]
  2. Qadirvirtide and Qadir-C30: His work also includes invention of anti-HIV drugs, Qadirvirtide[12][13][14][15] and Qadir-C30.[16][17][18] These are fusion inhibitors that may be used as prophylaxis or for the treatment of AIDS. These are synthetic peptides composed of 36 and 30 amino acids respectively. These block the entry of HIV genome into human CD4 cells by binding to HR1 region of spike protein of HIV, so that the virus can not come close to the human cell membrane and ultimately fusion of the viral envelope with human cell membrane is prevented.[19]
  3. Qadir theory of cancer etiology: He has posed that viruses are the cause of cancer, the idea was presented as a theory of cancer etiology.[20][21][22] He postulated that "Viruses are the causative agents of cancer: 100% of cancer patients contain virus/es in their body which are responsible for the cancer." He also argued that some studies have opposed the idea, but he rejected them because laboratory methods were not used to detect viruses in those studies. The theory was concluded with the point that, in near future, viruses will be isolated from all cancer patients as causative agent of a specific cancer.[23]
  4. Qadirphages: He discovered local bacteriophages to be used as anti-bacterial products which were named as Qadirphages.[24][25] The evolution of antibiotic resistance in bacteria has increased research in the field of therapies to search alternative methods to control the infections. Qadir isolated local phages, characterized them and found their antibacterial activities. The phages showed maximum propagation at 37 °C indicating that these work best at human body temperature. SDS-PAGE analysis confirmed the presence of protein cover and showed the various bands ranging from 10 to 200 kDa. Nucleic acid analysis confirmed the presence of RNA with a size of approximately 20 kb. Transmission electron microscopy indicated that the isolated phages belonged to Siphoviridae, Leviviridae, and Podoviridae families.[26]
  5. Fungal Research: He also discovered new genes in local fungi which are involved in curing skin diseases caused by these local fungi.[27]
  6. QadirVID-19: He designed a fusion inhibitor for specific treatment of COVID-19, which was named as QadirVID-19.[28] This drug is a synthetic peptide composed of 30 amino acids.[29] It is part of Heptad Repeat 2 (HR2) region of spike protein of 2019-nCoV which was found highly conserved region as it had 100% similarity, with BLAST scoring of 99.5 and E-value of 5e−24.[30]
  7. Publications: He has published more than 600 research articles.[31][32][33] He has also written and edited more 15 books in the field of medical sciences. Among them, "Rare and Uncommon Diseases"[34][35] and "Bacterial Diseases"[36] are famous.
  8. Mentorship: He is an HEC approved supervisor for PhD research in Pakistan.[8][37] He has contributed in health-related community awareness programs.[38][39]

Awards and recognition

Qadir was named best young research scholar by Higher Education Commission of Pakistan,[40][41] and Productive Scientist of Pakistan, by Pakistan Council for Science and Technology, Ministry of Science and Technology (Pakistan).[42][43] He received the Research Productivity Award, by Pakistan Council for Science and Technology, Ministry of Science and Technology (Pakistan).[44] He has also received a gold medal in the field of biotechnology from Pakistan Academy of Sciences (PAS).[45][46][47][48][49]

Fellowships and membership

Qadir is a Fellow of The Linnean Society of London, UK.[50] He is a member of the American Society for Microbiology[51] the International Dermoscopy Society (IDSS), Italy,[52] and the French Society for Cell Biology.[53] He is also member of other healthcare-related global societies.[54]

References

  1. ↑ "Dr. Imran Declared Top Scientist In Pharma Science By PCST". Retrieved 2019-07-09.
  2. ↑ "Dr. Imran Declared Top Scientist In Pharma Science By PCST". UrduPoint. Retrieved 2019-07-09.
  3. ↑ "Top in Pharma Science (in Urdu)". e.dunya.com.pk. Retrieved 2019-07-09.
  4. ↑ generator, metatags. "Khabrain Epaper". epaper.dailykhabrain.com.pk. Retrieved 2019-07-09.
  5. ↑ "Jang Multan 20.8.16". ResearchGate. Retrieved 2019-07-09.
  6. 1 2 "Scientist invents new test to diagnose cancer". The Nation. 2017-11-03. Retrieved 2019-07-09.
  7. ↑ "Dr. M. Imran Qadir". PlacesMap. Retrieved 2019-07-15.
  8. 1 2 "Personal Profile". Retrieved 2019-07-09.
  9. ↑ "Phage Therapy & Drug Design Laboratory". Retrieved 2020-02-27.
  10. ↑ "Muhammad Imran Qadir". KenzPub.
  11. ↑ Qadir, Muhammad Imran (2016). "Qadir test" (PDF). Pakistan Journal of Pharmaceutical Sciences. 29: 247–248.
  12. ↑ "HIV Fusion Inhibitors (definition)". www.reference.md.
  13. ↑ "Qadirvirtide - CTD". ctdbase.org.
  14. ↑ Qadir, Muhammad Imran (2011). "Qadirvirtide" (PDF). Pakistan Journal of Pharmaceutical Sciences. 24 (4): 593–595. PMID 21959827.
  15. ↑ "PakMediNet". www.pakmedinet.com. Retrieved 2019-07-09.
  16. ↑ Qadir, M.I.; Malik, S.A. (2011). "Genetic Variation in the HR Region of the env Gene of HIV: A Perspective for Resistance to HIV Fusion Inhibitors". AIDS Research and Human Retroviruses. 27 (1): 57–63. doi:10.1089/aid.2010.0098. PMID 20874419. S2CID 44371106. Retrieved 2019-12-09.
  17. ↑ "Qadirvirtide & Qadir-C30". BZUPAGES. Retrieved 2019-12-09.
  18. ↑ "Muhammad Imran Qadir". KenzPub. Retrieved 2019-12-13.
  19. ↑ "Qadirvirtide". Asian Digital Library.
  20. ↑ "Multan professor presents theory on cancer cause". Samaa TV. 14 February 2017.
  21. ↑ "BZU Teacher Presents Theory On Cancer Cause". Retrieved 2019-07-09.
  22. ↑ "Roznama Dunya". e.dunya.com.pk. Retrieved 2019-07-09.
  23. ↑ Qadir, Muhammad Imran (2018). "Qadir Theory of Cancer Etiology". Critical Reviews in Eukaryotic Gene Expression. 28 (1): 13–15. doi:10.1615/CritRevEukaryotGeneExpr.2018019561. ISSN 1045-4403. PMID 29773012.
  24. ↑ generator, metatags. "Khabrain Epaper". epaper.dailykhabrain.com.pk. Retrieved 2019-07-09.
  25. ↑ Sajjad, Sahir; Qadir, Muhammad Imran (2017). "Phage Therapy against Streptococcus pneumoniae: Modern Tool to Control Pneumonia". Critical Reviews in Eukaryotic Gene Expression. 27 (4): 289–295. doi:10.1615/CritRevEukaryotGeneExpr.2017019527. ISSN 1045-4403. PMID 29283323.
  26. ↑ Chauhdary, Zunera; Qadir, Muhammad Imran (2018). "Antibacterial Activity of Novel Strains of Bacteriophages: An Experimental Approach". Critical Reviews in Eukaryotic Gene Expression. 28 (1): 1–12. doi:10.1615/CritRevEukaryotGeneExpr.2017019608. ISSN 1045-4403. PMID 29773011.
  27. ↑ "Pakistani scientists discover new genes in fungus for skin disease cure". 2016-07-20.
  28. ↑ "Formula for Medicine of Corona". Daily Express. Retrieved 2020-09-15.
  29. ↑ Qadir, Muhammad Imran (2020). "QadirVID-19: A fusion inhibitor against Novel Coronavirus-2019 for specific management of COVID-19" (PDF). Pak J Pharm Sci. 33 (5): 2187–2191. doi:10.36721/PJPS.2020.33.5.REG.2187-2191.1. PMID 33824128.
  30. ↑ EBSCO's databases. "QadirVID-19".
  31. ↑ "Muhammad Imran Qadir - Google Scholar Citations". scholar.google.com.pk.
  32. ↑ "Profile: M. Imran Qadir". ResearchGate.
  33. ↑ "ORCID".
  34. ↑ Qadir, Muhammad Imran (16 October 2018). Rare and Uncommon Diseases. ISBN 9781527519503.
  35. ↑ "National Library of Medicine".
  36. ↑ Qadir, Muhammad Imran (9 September 2020). Bacterial Diseases. ISBN 9789811473753.
  37. ↑ "Search Engine for HEC Approved Supervisors (Eportal)". www.hec.gov.pk. Retrieved 2019-07-09.
  38. ↑ Tribune.com.pk (2012-10-01). "Cardiac problems: 'Stress, greasy food, lack of exercise unhealthy'". The Express Tribune. Retrieved 2019-07-09.
  39. ↑ "Kidney, bladder diseases: public awareness campaign launched". Business Recorder. 2013-10-15. Retrieved 2019-07-09.
  40. ↑ "HEC announces best young Pakistani research scholar". Times of Islamabad. 27 June 2016.
  41. ↑ "Education single means to ensure socio-economic development: Rana Tanveer". www.thenews.com.pk. 2016-06-26.
  42. ↑ "Productive Scientist 2010". gcuf.edu.pk. Retrieved 2019-07-09.
  43. ↑ Directory of Productive Scientists of Pakistan (PDF). Pakistan Council for Science & Technology. 2017. p. 283.
  44. ↑ Research Productivity Award (PDF). Pakistan Council for Science & Technology. 2017. p. 24.
  45. ↑ "Dr. Imran Qadir Received Gold Medal in Biotechnology". Retrieved 2019-12-10.
  46. ↑ "Jahan-e-Ilmo-adab". Retrieved 2019-12-10.
  47. ↑ "Roznama Express". Retrieved 2019-12-11.
  48. ↑ "Gold Medal". Naw-e-Waqat. p. Page 3, Column 3. Retrieved 2019-12-13.
  49. ↑ "PAS Gold Medals, Prizes and Certificates-2019" (PDF). PAS Newsletter. Page.3. January 2020. Retrieved 2020-08-23.
  50. ↑ "Fellows Elected, Oct 2018-Jan 2019" (PDF). The Linnean. 35: 41. April 2019.
  51. ↑ "Member Profile View". myasm.asm.org. Retrieved 2019-07-09.
  52. ↑ "List of IDS members – International Dermoscopy Society". Retrieved 2019-07-09.
  53. ↑ "Muhammad Imran Qadir, auteur sur SBCF". SBCF. Retrieved 2019-07-09.
  54. ↑ "Members Of Pakistan". Trialect. Retrieved 2019-12-13.
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