2011–13: Muhteşem Yüzyıl

Uzerli's most known breakout role is as Hürrem Sultan in the historical television drama series Muhteşem Yüzyıl, directed by the Taylan Brothers. In 2010, after an eight-month search to find the best actress for this role, she was chosen by Meral Okay, the series' screenwriter, and Timur Savcı, the series' producer.^[5] About her selection, she said: "Until one day the phone rang, I was invited for a casting in Turkey, and then immediately I started living in Istanbul almost full time."^[6] She lived in a hotel for two years during the shooting of Muhteşem Yüzyıl. She shared the leading role with Halit Ergenç, Okan Yalabık and Nebahat Çehre. She won the Golden Butterfly Award for Best Actress for this part in 2012. In 2013, she left the series due to health concerns, reportedly a burnout.^[7] From episode 103 and onwards, Vahide Perçin was cast in to play an older version of Hürrem.^[8]

2014–present: Gecenin Kraliçesi and Annemin Yarası

At the end of 2014, Uzerli signed a contract with O3, the Turkish production company of MBC Group.^[9][10][11] As of December 2014, she was still living in Berlin, but planning to move to Istanbul.^[10] In December 2014, Star TV released a video and a photo of Uzerli introducing her as one of its stars in 2015.^[12][13] In October 2015, she was again introduced among the TV's stars for 2016.^[14][15] About her future, she says: "I am trying to build on my international success within any industry where actors are respected as artists, and where I can find great scripts that allow me to delve into a story that leaves the here and now behind."^[6] In March 2015, it was finalized that Uzerli would share the leading role with Murat Yıldırım in her new TV series.^[16] The series' name was later announced as Gecenin Kraliçesi.^[17] It is directed by Muhteşem Yüzyıl directors, the Taylan Brothers. Some of the scenes for this series were filmed in Cannes, France.^[17] The shooting later continued in Rize, Turkey.^[18] It premiered on Star TV in January 2016.^[19]

In addition to her career in television, Uzerli also appeared in a cinema movie in 2016, titled Annemin Yarası.^[20] The film was released in March 2016.^[20] Her co-stars include Ozan Güven, Okan Yalabık, and Belçim Bilgin.^[21] Between 2016 and 2017, she appeared in a guest role on Eşkiya Dünyaya Hükümdar Olmaz.^[22] In 2017, she continued her movie career by appearing in Cingöz Recai opposite Kenan İmirzalıoğlu, although the film was not a box office success.^[23] Later in the same year, she shared the leading role with Özcan Deniz and Aslı Enver in the movie Öteki Taraf.^[24] In 2019, Uzerli auditioned for a role in the third season of the Netflix original series Dark.^[25] She also appeared as the lead role in the movie Kovan, the proceeds of which were donated to Haluk Levent's Ahbap foundation.^[26]

As a model, she is the face of Blue Diamond and Maison Novague. She was also the face of Russian brand Faberlic. She has appeared on the cover of FabUk and has done photoshoots and videos for Louis Vuitton and Vogue. She has a photography page on Instagram.