Menna R. Clatworthy FRCP FMedSci FLSW is a British immunologist who is Professor of Translational Medicine at the University of Cambridge. She studies human tissue immunity. She is a Fellow of the Academy of Medical Sciences and was elected to the European Molecular Biology Organization in 2022.

Early life and education

Clatworthy completed an undergraduate degree in medicine at Cardiff University. She specialised in nephrology at the University of Cambridge, where she undertook a doctorate in medicine. She was supported by the British Renal Association Raine Award.^[1]

Research and career

Clatworthy looks to understand the types of immune cells that live within human organs, and how their local environment impacts their function.^[2][3] She studies human tissue immunity in lymphoid and non-lymphoid organs.^[2] She makes use of single cell genome sequencing and advanced imaging to uncover how environmental cues shape immune responses in health and disease. Clatworthy established the Cambridge Tissue Immunity Laboratory.^[4] As part of this, she is responsible for the kidney cell atlas and the bladder cell atlas.^[2]

Clatworthy has studied the role of the immune system in neurological disorders, including Parkinson's disease and depression. To do this, she made use of a mouse model. She noticed that plasma cells within the dura (the outer part of the meninges) were aligned along the border of the dural venous sinuses.^[5] On further investigation, Clatworthy realised that these antibodies were producing Immunoglobulin A, antibodies which are typically found in the gut.^[5] She investigated the origins of these bacteria, and showed that they originated in the intestine. She argued that these antibodies flow to the dural venous sinuses to protect the brain from microbes.^[5]

Clatworthy was elected to the Academy of Medical Sciences in 2020 and the EMBO in 2022.^[6][7] During the COVID-19 pandemic, Clatworthy investigated the immune responses of people who suffered severe and asymptomatic COVID-19.^[8]

In 2020, Clatworthy was elected a Fellow of the Learned Society of Wales.^[9]

Selected publications

• Naeha Subramanian; Kannan Natarajan; Menna R Clatworthy; Ze Wang; Ronald N Germain (11 April 2013). "The adaptor MAVS promotes NLRP3 mitochondrial localization and inflammasome activation". Cell. 153 (2): 348–61. doi:10.1016/J.CELL.2013.02.054. ISSN 0092-8674. PMC 3632354. PMID 23582325. Wikidata Q24338420.
• Ivan Angulo; Oscar Vadas; Fabien Garçon; et al. (15 November 2013). "Phosphoinositide 3-kinase δ gene mutation predisposes to respiratory infection and airway damage". Science. 342 (6160): 866–71. doi:10.1126/SCIENCE.1243292. ISSN 0036-8075. PMC 3930011. PMID 24136356. Wikidata Q24603171.
• K G Smith; Menna R Clatworthy (1 May 2010). "FcgammaRIIB in autoimmunity and infection: evolutionary and therapeutic implications". Nature Reviews Immunology. 10 (5): 328–343. doi:10.1038/NRI2762. ISSN 1474-1733. PMC 4148599. PMID 20414206. Wikidata Q37736263.
• Menna, Clatworthy (2012). Transplantation at a glance. Wiley-Blackwell. ISBN 978-0-470-65842-0. OCLC 1313748607.

References