Malayalam

Meera Jasmine made her debut in the Malayalam film Soothradharan.^[13] Her second film was Gramophone, directed by Kamal, in which she appeared alongside Navya Nair and Dileep.^[13] Her role as a Jewish girl was appreciated by Malayalam critics. Her third film was Swapnakkoodu, a romantic comedy alongside Prithviraj Sukumaran, Kunchako Boban, Jayasurya, and Bhavana under director Kamal. Her performance was appreciated and the film was a high commercial success.^[1] Among the five main characters, the one who scored the most was again Meera.^[14]

She rose to fame in Malayalam cinema with the film Kasthooriman directed by her mentor Lohithadas,^[15] where she played a happy go lucky yet emotionally complex character. She received her first Filmfare award for her performance in Kasthooriman. The film was a success at the box office, running for 100 days. The same year, she acted in T. V. Chandran's acclaimed Padam Onnu Oru Vilapam. She played a 15-year-old Muslim girl who was forced to marry an older man, for which she was awarded a State Award and the National Award in addition with several other awards.^[16] It was followed by her performance as Raziya in Perumazhakkalam alongside Kavya Madhavan.

In the film Achuvinte Amma (2005), she enacted the young, adorable character Achu.^[17] She then paired with Mohanlal in Rasathanthram (2006). She played as a girl pretending to be a boy due to the pressure of circumstances in the first half of the film . The film went on to become a commercial success. Her next film with Dileep – Vinodayathra, which again was directed by Sathyan Anthikkad. She was next featured opposite Mammootty in the critically acclaimed film Ore Kadal. The film was showcased in film festivals and won awards. Her performance as an innocent middle-class woman won praise from audiences. Media quoted her as, "Matching step with the megastar in this histrionic race is Meera Jasmine, who amazes you with a stunning delineation of her difficult role" . Her next film was Calcutta News with Dileep. Blessy, who introduced her to film field, was the director of Calcutta News. In Innathe Chintha Vishayam (2008), she collaborated with Sathyan Anthikkad for his fourth consecutive film, again opposite Mohanlal, but failed to succeed. Her next films Minnaminnikoottam with Kamal and Rathri Mazha with Lenin Rajendran, which released after a long post-production delay, were box office failures.

More than a year later, she played the role of a playback singer in Rajeev Anchal's Paattinte Palazhy.^[18] Though the film was commercially not successful, her character was noted and her performance gave her a comeback. Her next film, Four Friends, was a multi-starrer directed by Saji Surendran. She played the role of a cancer patient in this film. In the 2011 film Mohabbat, she played the lead role opposite Anand Michael and Munna.

After a brief hiatus, she began committing films by late 2012. She was keen in choosing more women-centric roles and in Babu Janardhanan's Lisammayude Veedu, a sequel to the 2006 film Achanurangatha Veedu, her role was that of a serial rape victim. She acted opposite Mohanlal in Siddique's comedy film Ladies and Gentleman. Her latest project is Shajiyem's Ms. Lekha Tharoor Kanunnathu, a fantasy film.^[19] In 2014, she starred opposite Jayaram in Sugeeth's family film, Onnum Mindathe, but the film failed at the box office. She signed up for Ithinumappuram, a period film based in the 1970s, in which she plays a highly orthodox and rich Nair woman who falls in love with someone from a lower caste and gets married against her parents' will.^[20]

After that, she acted in the movie Mazhaneerthullikal directed by V. K. Prakash but the movie was not released. In 2016, she co-starred with Anoop Menon, Joju George and Kaniha in the crime thriller 10 Kalpanakal directed by Don Max, but the film was not a theatrical success. However, the film received rave reviews from critics and was praised for its script, direction and cast.

In 2018, Meera made a comeback after a gap of two years with a guest appearance in Kalidas Jayaram starrer Poomaram directed by Abrid Shine. After a long hiatus, in 2022 Meera joined hands with Sathyan Anthikad for a family entertainer 'Makal' alongside Jayaram. The film received decent reviews and Meera was praised for her subtle act.

Tamil, Telugu and Kannada

Meera Jasmine's Tamil debut was Run, directed by Lingusamy, which became a high success in Tamil Nadu and made her a sought-after actress.^[1] The success of Run and gave her the chance to work with the established actors of the Tamil film industry.Though her successive films did not fare as well,^[1] she was noticed by director Mani Ratnam who gave her a role in Aayutha Ezhuthu.^[1] She later appeared in N. Lingusamy's Sandakozhi and SS Stanley's Mercury Pookkal.^[21] Her latest Tamil film, Mambattiyan got released in December 2011.^[22][23]

Meera Jasmine became noted in the Telugu film industry with Run, the dubbed version of the same-titled Tamil film. She was seen in the Telugu films in 2004 with Ammayi Bagundi and Gudumba Shankar, also entered Kannada cinema by co-starring with Puneet Rajkumar in Maurya. Her Kannada film Arasu again with Puneet Rajkumar and Ramya was a hit. Her other Kannada films include Devaru Kotta Thangi and Ijjodu. Ijjodu, in which she played Chenni, a Basavi woman, who ends up becoming a sex worker, was screened at four prestigious domestic film festivals and garnered critical acclaim.^[24]

Meera Jasmine's biggest commercial success in Telugu remains Bhadra with Ravi Teja in the male lead. Her other Telugu films are Raraju, Maharadhi, Yamagola Malli Modalayindi, Gorintaku and Maa Ayana Chanti Pilladu, in which she is paired for a second time with Sivaji.