MLLT3

MLLT3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2LM0, 2MV7, 4TMP, 2N4Q, 5HJB, 5HJD
Identifiers
Aliases	MLLT3, AF9, YEATS3, myeloid/lymphoid or mixed-lineage leukemia; translocated to, 3, super elongation complex subunit, MLLT3 super elongation complex subunit
External IDs	OMIM: 159558 MGI: 1917372 HomoloGene: 37933 GeneCards: MLLT3
Gene location (Human)
Chr.	Chromosome 9 (human)
End	20,622,499 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	87,951,601 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; rectum; ; Achilles tendon; ; endothelial cell; ; stromal cell of endometrium; ; islet of Langerhans; ; sural nerve; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; gallbladder;
	Top expressed in
	metatarsal bones; ; plantaris muscle; ; extensor digitorum longus muscle; ; intercostal muscle; ; triceps brachii muscle; ; temporal muscle; ; sternocleidomastoid muscle; ; secondary oocyte; ; digastric muscle; ; epithelium of stomach;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; chromatin binding; histone binding; lysine-acetylated histone binding; modification-dependent protein binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	transcription elongation factor complex; extracellular exosome; nucleus; nucleoplasm; chromosome;
Biological process	positive regulation of Wnt signaling pathway, planar cell polarity pathway; regulation of transcription, DNA-templated; negative regulation of canonical Wnt signaling pathway; transcription, DNA-templated; segment specification; anterior/posterior pattern specification; transcription by RNA polymerase II; transcription elongation from RNA polymerase II promoter; positive regulation of transcription, DNA-templated; regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	4300
	70122
	ENSG00000171843
	ENSMUSG00000028496
	P42568
	A2AM29
	NM_004529; NM_001286691
	NM_001286158; NM_027326; NM_029931
	NP_001273620; NP_004520
NP_001273087; NP_081602; NP_084207; NP_001391884; NP_001391885;
	NP_001391886; NP_001391887
	Wikidata
View/Edit Human	View/Edit Mouse

Protein AF-9 is a protein that in humans is encoded by the MLLT3 gene.^[5]^[6]^[7]

Interactions

MLLT3 has been shown to interact with BCOR.^[8]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000171843 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028496 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Nakamura T, Alder H, Gu Y, Prasad R, Canaani O, Kamada N, Gale RP, Lange B, Crist WM, Nowell PC, et al. (Jul 1993). "Genes on chromosomes 4, 9, and 19 involved in 11q23 abnormalities in acute leukemia share sequence homology and/or common motifs". Proc Natl Acad Sci U S A. 90 (10): 4631–5. Bibcode:1993PNAS...90.4631N. doi:10.1073/pnas.90.10.4631. PMC 46566. PMID 8506309.
↑ Iida S, Seto M, Yamamoto K, Komatsu H, Tojo A, Asano S, Kamada N, Ariyoshi Y, Takahashi T, Ueda R (Nov 1993). "MLLT3 gene on 9p22 involved in t(9;11) leukemia encodes a serine/proline rich protein homologous to MLLT1 on 19p13". Oncogene. 8 (11): 3085–92. PMID 8414510.
↑ "Entrez Gene: MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3".
↑ Srinivasan, R Sathish; de Erkenez Andrea C; Hemenway Charles S (May 2003). "The mixed lineage leukemia fusion partner AF9 binds specific isoforms of the BCL-6 corepressor". Oncogene. 22 (22): 3395–406. doi:10.1038/sj.onc.1206361. ISSN 0950-9232. PMID 12776190.

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Huynh KD, Fischle W, Verdin E, Bardwell VJ (2000). "BCoR, a novel corepressor involved in BCL-6 repression". Genes Dev. 14 (14): 1810–23. doi:10.1101/gad.14.14.1810. PMC 316791. PMID 10898795.
García-Cuéllar MP, Zilles O, Schreiner SA, et al. (2001). "The ENL moiety of the childhood leukemia-associated MLL-ENL oncoprotein recruits human Polycomb 3". Oncogene. 20 (4): 411–9. doi:10.1038/sj.onc.1204108. PMID 11313972.
Hemenway CS, de Erkenez AC, Gould GC (2001). "The polycomb protein MPc3 interacts with AF9, an MLL fusion partner in t(9;11)(p22;q23) acute leukemias". Oncogene. 20 (29): 3798–805. doi:10.1038/sj.onc.1204478. PMID 11439343.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Srinivasan RS, de Erkenez AC, Hemenway CS (2003). "The mixed lineage leukemia fusion partner AF9 binds specific isoforms of the BCL-6 corepressor". Oncogene. 22 (22): 3395–406. doi:10.1038/sj.onc.1206361. PMID 12776190.
Erfurth F, Hemenway CS, de Erkenez AC, Domer PH (2004). "MLL fusion partners AF4 and AF9 interact at subnuclear foci". Leukemia. 18 (1): 92–102. doi:10.1038/sj.leu.2403200. PMID 14603337.
Montemurro L, Tonelli R, Fazzina R, et al. (2004). "Identification of two MLL-MLLT3 (alias MLL-AF9) chimeric transcripts in the MOLM-13 cell line". Cancer Genet. Cytogenet. 154 (1): 96–7. doi:10.1016/j.cancergencyto.2004.01.029. PMID 15381384.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Martino V, Tonelli R, Montemurro L, et al. (2006). "Down-regulation of MLL-AF9, MLL and MYC expression is not obligatory for monocyte-macrophage maturation in AML-M5 cell lines carrying t(9;11)(p22;q23)". Oncol. Rep. 15 (1): 207–11. doi:10.3892/or.15.1.207. PMID 16328057.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000171843 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028496 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8506309-5] Nakamura T, Alder H, Gu Y, Prasad R, Canaani O, Kamada N, Gale RP, Lange B, Crist WM, Nowell PC, et al. (Jul 1993). "Genes on chromosomes 4, 9, and 19 involved in 11q23 abnormalities in acute leukemia share sequence homology and/or common motifs". Proc Natl Acad Sci U S A. 90 (10): 4631–5. Bibcode:1993PNAS...90.4631N. doi:10.1073/pnas.90.10.4631. PMC 46566. PMID 8506309.

[pmid8414510-6] Iida S, Seto M, Yamamoto K, Komatsu H, Tojo A, Asano S, Kamada N, Ariyoshi Y, Takahashi T, Ueda R (Nov 1993). "MLLT3 gene on 9p22 involved in t(9;11) leukemia encodes a serine/proline rich protein homologous to MLLT1 on 19p13". Oncogene. 8 (11): 3085–92. PMID 8414510.

[entrez-7] "Entrez Gene: MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3".

[pmid12776190-8] Srinivasan, R Sathish; de Erkenez Andrea C; Hemenway Charles S (May 2003). "The mixed lineage leukemia fusion partner AF9 binds specific isoforms of the BCL-6 corepressor". Oncogene. 22 (22): 3395–406. doi:10.1038/sj.onc.1206361. ISSN 0950-9232. PMID 12776190.

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[4]

[5]

[6]

[7]

[8]

Interactions

References

Further reading