ME2 (gene)

ME2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1DO8, 1EFK, 1EFL, 1GZ3, 1GZ4, 1PJ2, 1PJ3, 1PJ4, 1PJL, 1QR6
Identifiers
Aliases	ME2, ODS1, malic enzyme 2
External IDs	OMIM: 154270 MGI: 2147351 HomoloGene: 37615 GeneCards: ME2
Gene location (Human)
Chr.	Chromosome 18 (human)
End	50,954,257 bp
RNA expression pattern
	Top expressed in
	jejunal mucosa; ; monocyte; ; duodenum; ; right ventricle; ; rectum; ; spongy bone; ; vena cava; ; seminal vesicula; ; appendix; ; thoracic diaphragm;
	n/a
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	malate dehydrogenase (decarboxylating) (NAD+) activity; electron transfer activity; oxidoreductase activity; NAD binding; oxaloacetate decarboxylase activity; catalytic activity; metal ion binding; malic enzyme activity; malate dehydrogenase (decarboxylating) (NADP+) activity;
Cellular component	mitochondrion; mitochondrial matrix;
Biological process	regulation of NADP metabolic process; metabolism; pyruvate metabolic process; malate metabolic process; electron transport chain; tricarboxylic acid cycle;
	Sources:Amigo / QuickGO
Orthologs
	4200
	107029
	ENSG00000082212
	n/a
	P23368
	Q99KE1
	NM_001168335; NM_002396
	NM_145494
	NP_001161807; NP_002387
	NP_663469
	Wikidata
View/Edit Human	View/Edit Mouse

NAD-dependent malic enzyme, mitochondrial is a protein that in humans is encoded by the ME2 gene.^[4]^[5] This gene encodes a mitochondrial NAD-dependent malic enzyme, a homotetrameric protein, that catalyzes the oxidative decarboxylation of malate to pyruvate. It had previously been weakly linked to a syndrome known as Friedreich ataxia that has since been shown to be the result of mutation in a completely different gene.^[5]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000082212 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Loeber G, Infante AA, Maurer-Fogy I, Krystek E, Dworkin MB (Mar 1991). "Human NAD(+)-dependent mitochondrial malic enzyme. cDNA cloning, primary structure, and expression in Escherichia coli". J Biol Chem. 266 (5): 3016–21. doi:10.1016/S0021-9258(18)49948-6. PMID 1993674.
1 2 "Entrez Gene: ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial".

Siebert G, Ritter H, Kömpf J (1980). "Mitochondrial malic enzyme (E.C.1.1.1.40) in human leukocytes: formal genetics and population genetics". Hum. Genet. 51 (3): 319–22. doi:10.1007/bf00283401. PMID 511162. S2CID 28855152.
Saha N, Jeremiah SJ, Povey S (1978). "Further data on mitochondrial malic enzyme in man". Hum. Hered. 28 (6): 421–5. doi:10.1159/000152993. PMID 680703.
Taroni F, Gellera C, Di Donato S (1988). "Evidence for two distinct mitochondrial malic enzymes in human skeletal muscle: purification and properties of the NAD(P)+-dependent enzyme". Biochim. Biophys. Acta. 916 (3): 446–54. doi:10.1016/0167-4838(87)90191-9. PMID 3689803.
Bukato G, Kochan Z, Swierczyński J (1996). "Different regulatory properties of the cytosolic and mitochondrial forms of malic enzyme isolated from human brain". Int. J. Biochem. Cell Biol. 27 (10): 1003–8. doi:10.1016/1357-2725(95)00080-9. PMID 7496989.
Bukato G, Kochan Z, Swierczyński J (1995). "Purification and properties of cytosolic and mitochondrial malic enzyme isolated from human brain". Int. J. Biochem. Cell Biol. 27 (1): 47–54. doi:10.1016/1357-2725(94)00057-3. PMID 7757881.
Xu Y, Bhargava G, Wu H, et al. (1999). "Crystal structure of human mitochondrial NAD(P)+-dependent malic enzyme: a new class of oxidative decarboxylases". Structure. 7 (8): R877–89. doi:10.1016/S0969-2126(99)80115-4. PMID 10477256.
Yang Z, Floyd DL, Loeber G, Tong L (2000). "Structure of a closed form of human malic enzyme and implications for catalytic mechanism". Nat. Struct. Biol. 7 (3): 251–7. doi:10.1038/73378. PMID 10700286. S2CID 23469024.
Yang Z, Batra R, Floyd DL, et al. (2000). "Potent and competitive inhibition of malic enzymes by lanthanide ions". Biochem. Biophys. Res. Commun. 274 (2): 440–4. doi:10.1006/bbrc.2000.3163. PMID 10913357.
Butta N, González-Manchón C, Arias-Salgado EG, et al. (2001). "Cloning and functional characterization of the 5' flanking region of the human mitochondrial malic enzyme gene. Regulatory role of Sp1 and AP-2". Eur. J. Biochem. 268 (10): 3017–27. doi:10.1046/j.1432-1327.2001.02194.x. hdl:10261/73615. PMID 11358520.
Yanaihara N, Kohno T, Takakura S, et al. (2001). "Physical and transcriptional map of a 311-kb segment of chromosome 18q21, a candidate lung tumor suppressor locus". Genomics. 72 (2): 169–79. doi:10.1006/geno.2000.6454. PMID 11401430.
Yang Z, Lanks CW, Tong L (2002). "Molecular mechanism for the regulation of human mitochondrial NAD(P)+-dependent malic enzyme by ATP and fumarate". Structure. 10 (7): 951–60. doi:10.1016/S0969-2126(02)00788-8. PMID 12121650.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. S2CID 23783563.
Tao X, Yang Z, Tong L (2004). "Crystal structures of substrate complexes of malic enzyme and insights into the catalytic mechanism". Structure. 11 (9): 1141–50. doi:10.1016/S0969-2126(03)00168-0. PMID 12962632.
Navarro-Lérida I, Martínez Moreno M, Roncal F, et al. (2004). "Proteomic identification of brain proteins that interact with dynein light chain LC8". Proteomics. 4 (2): 339–46. doi:10.1002/pmic.200300528. PMID 14760703. S2CID 8868600.
Greenberg DA, Cayanis E, Strug L, et al. (2005). "Malic enzyme 2 may underlie susceptibility to adolescent-onset idiopathic generalized epilepsy". Am. J. Hum. Genet. 76 (1): 139–46. doi:10.1086/426735. PMC 1196416. PMID 15532013.
Hung HC, Chien YC, Hsieh JY, et al. (2005). "Functional roles of ATP-binding residues in the catalytic site of human mitochondrial NAD(P)+-dependent malic enzyme". Biochemistry. 44 (38): 12737–45. doi:10.1021/bi050510b. PMID 16171388.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000082212 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1993674-4] Loeber G, Infante AA, Maurer-Fogy I, Krystek E, Dworkin MB (Mar 1991). "Human NAD(+)-dependent mitochondrial malic enzyme. cDNA cloning, primary structure, and expression in Escherichia coli". J Biol Chem. 266 (5): 3016–21. doi:10.1016/S0021-9258(18)49948-6. PMID 1993674.

[entrez-5] 1 2 "Entrez Gene: ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial".

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References

Further reading