Lowell is a surname, see "Lowell family" for name origin. Notable people with the surname include:

• The Lowell family, a prominent family name in England and America
• Abbe Lowell (born 1952), American defense attorney
• Abbott Lawrence Lowell (1856–1943), lawyer, historian, philanthropist, and former President of Harvard University
• Amy Lowell (1874–1925), poet, critic, publisher, and sister of Abbott Lawrence and Percival Lowell
• Andrea Lowell (born 1983), actress and model
• Anna Cabot Lowell (1819–1874), American writer
• Augustus Lowell (1830–1900), businessman, philanthropist, and father of Percival, Abbott Lawrence, and Amy Lowell
• Carey Lowell (born 1961), actress and wife of actor Richard Gere
• Catelynn Lowell (Catelynn Baltierra; born 1992), American reality television personality, author, and public speaker
• Charles Russell Lowell, Sr. (1782–1861), Unitarian pastor, son of The Old Judge, father of James Russell, and great-great grandfather of Robert Lowell
• Charles Russell Lowell (1835–1864), Union General and American Civil War hero
• Charlie Lowell (born 1973), keyboardist for Jars of Clay
• Chipper Lowell, American comedian
• Chris Lowell (born 1984), actor
• Christopher Lowell (Richard Lowell Madden; born 1955), interior decorator and television personality
• Delmar R. Lowell (1844–1912), pastor, Civil War veteran, and genealogist
• Edward Jackson Lowell (1845–1894), author and father of Guy Lowell
• Eric Lowell (born 1935), English footballer
• Frances Lowell (1886 – not earlier than 1952), American educational psychologist
• Francis Cabot Lowell (businessman) (1775–1817), businessman and namesake of Lowell, Massachusetts
• Francis Cabot Lowell (judge) (1855–1911), United States Congressman and Federal Judge
• Guy Lowell (1870–1927), architect and landscape designer
• Harry Lowell (born 1971), American television and feature film producer
• Helen Lowell (Helen Lowell Robb; 1866–1937), American stage and film actress
• James A. Lowell (1849–1900), Canadian merchant and politician
• James Arnold Lowell (1869–1933), American jurist
• James Russell Lowell (1819–1891), American poet and politician
• Joan Lowell (1902–1967), actress and newspaper reporter
• John Lowell (1743–1802), aka The Old Judge, United States Federal Judge appointed by President George Washington
• John Lowell, Jr. (lawyer) (1769–1840), aka The Boston Rebel, Federalist lawyer and son of The Old Judge
• John Lowell, Jr. (philanthropist) (1799–1836), son of Industrialist Francis Cabot Lowell and founder of the Lowell Institute
• John Amory Lowell (1798–1881), businessman and philanthropist
• John Lowell (judge) (1824–1897), United States Federal judge and son of John Amory Lowell
• Josephine Shaw Lowell (1843–1905), sister of American Civil War hero Robert Gould Shaw, first woman to hold a public office in New York City, and wife of Gen. Charles Russell Lowell
• Joshua A. Lowell (1801–1874), United States Representative from Maine (1839–1843)
• Maria White Lowell (1821–1853), poet, abolitionist, and wife of James Russell Lowell
• Mike Lowell (born 1974), baseball player for the Boston Red Sox
• Nathan Lowell (born 1952), American science fiction writer
• Norman Lowell (born 1946), founder of the extreme-right Maltese political party, Imperium Europa
• Orson Lowell (1871–1956), American artist and illustrator
• Percival Lowell (1855–1916), author, astronomer, founder of Lowell Observatory, and brother of Amy and Abbott Lawrence Lowell
• Ralph Lowell (1890–1978), businessman, philanthropist, and founding force behind Boston's WGBH public television
• Robert Lowell (1917–1977), poet and lecturer
• Rupe Lowell (1893–1980), Australian rules footballer
• Scott Lowell (born 1965), actor
• Spencer Lowell (born 1983), American photographer
• Tom Lowell (born 1941), American film and television actor
• Waverly Lowell, American archivist
• William Lowell Sr. (1863–1954), American dentist, inventor of a wooden golf tee
• William Lowell Jr. (1897–1976), manufacturer of golf tees and industrial packaging specialist

Fictional characters:

• Carmen Lowell, main character in the book and film The Sisterhood of the Traveling Pants
• Christopher Lowell, stage name for Richard Lowell Madden, interior designer and TV host
• Elizabeth Lowell, pen name for Ann Maxwell, popular romance writer
• Ellen Lowell, fictional character from the American daytime soap opera As the World Turns
• Yuri Lowell, main character in the game Tales of Vesperia