LRRK1

LRRK1
Identifiers
Aliases	LRRK1, RIPK6, Roco1, leucine-rich repeat kinase 1, leucine rich repeat kinase 1, OSMD
External IDs	OMIM: 610986 MGI: 2142227 HomoloGene: 23464 GeneCards: LRRK1
Gene location (Human)
Chr.	Chromosome 15 (human)
End	101,078,257 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	66,038,098 bp
RNA expression pattern
	Top expressed in
	lymph node; ; appendix; ; transverse colon; ; spleen; ; monocyte; ; minor salivary gland; ; rectum; ; stromal cell of endometrium; ; sural nerve; ; thymus;
	Top expressed in
	right lung lobe; ; left lung; ; medullary collecting duct; ; left lung lobe; ; conjunctival fornix; ; epithelium of stomach; ; cervix; ; calvaria; ; spleen; ; Paneth cell;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	kinase activity; transferase activity; nucleotide binding; protein kinase activity; GTP binding; protein binding; ATP binding; metal ion binding; identical protein binding; protein serine/threonine kinase activity; signal transducer activity;
Cellular component	mitochondrion; cytoplasm; cytosol;
Biological process	positive regulation of canonical Wnt signaling pathway; osteoclast development; negative regulation of peptidyl-tyrosine phosphorylation; positive regulation of intracellular signal transduction; bone resorption; phosphorylation; positive regulation of peptidyl-tyrosine phosphorylation; intracellular signal transduction; protein phosphorylation;
	Sources:Amigo / QuickGO
Orthologs
	79705
	233328
	ENSG00000154237
	ENSMUSG00000015133
	Q38SD2
	Q3UHC2
	NM_024652; NM_001039843
	NM_146191
	NP_078928
	NP_666303
	Wikidata
View/Edit Human	View/Edit Mouse

Leucine-rich repeat serine/threonine-protein kinase 1 is an enzyme that in humans is encoded by the LRRK1 gene.^[5]^[6]^[7]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000154237 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000015133 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Nagase T, Nakayama M, Nakajima D, Kikuno R, Ohara O (May 2001). "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 8 (2): 85–95. doi:10.1093/dnares/8.2.85. PMID 11347906.
↑ Bosgraaf L, Van Haastert PJ (Dec 2003). "Roc, a Ras/GTPase domain in complex proteins" (PDF). Biochim Biophys Acta. 1643 (1–3): 5–10. doi:10.1016/j.bbamcr.2003.08.008. PMID 14654223. S2CID 45525061.
↑ "Entrez Gene: LRRK1 leucine-rich repeat kinase 1".

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Korr D, Toschi L, Donner P, et al. (2006). "LRRK1 protein kinase activity is stimulated upon binding of GTP to its Roc domain". Cell. Signal. 18 (6): 910–20. doi:10.1016/j.cellsig.2005.08.015. PMID 16243488.
Zody MC, Garber M, Sharpe T, et al. (2006). "Analysis of the DNA sequence and duplication history of human chromosome 15". Nature. 440 (7084): 671–5. Bibcode:2006Natur.440..671Z. doi:10.1038/nature04601. PMID 16572171.
Haugarvoll K, Toft M, Ross OA, et al. (2007). "Variants in the LRRK1 gene and susceptibility to Parkinson's disease in Norway". Neurosci. Lett. 416 (3): 299–301. doi:10.1016/j.neulet.2007.02.020. PMID 17324517. S2CID 10196943.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
Greggio E, Lewis PA, van der Brug MP, et al. (2007). "Mutations in LRRK2/dardarin associated with Parkinson disease are more toxic than equivalent mutations in the homologous kinase LRRK1". J. Neurochem. 102 (1): 93–102. doi:10.1111/j.1471-4159.2007.04523.x. PMID 17394548.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000154237 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000015133 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11347906-5] Nagase T, Nakayama M, Nakajima D, Kikuno R, Ohara O (May 2001). "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 8 (2): 85–95. doi:10.1093/dnares/8.2.85. PMID 11347906.

[pmid14654223-6] Bosgraaf L, Van Haastert PJ (Dec 2003). "Roc, a Ras/GTPase domain in complex proteins" (PDF). Biochim Biophys Acta. 1643 (1–3): 5–10. doi:10.1016/j.bbamcr.2003.08.008. PMID 14654223. S2CID 45525061.

[entrez-7] "Entrez Gene: LRRK1 leucine-rich repeat kinase 1".

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References

Further reading