Jeanne A. Hardy, PH.D.
Occupation(s)Professor of Biological and Biophysical Chemistry
Academic background
Alma materUtah State University, University of California - Berkeley
Doctoral advisorHillary C.M. Nelson

Jeanne A. Hardy is an American professor of biological and biophysical chemistry at the University of Massachusetts, Amherst. Her group's work is best known for designing allosteric binding sites and control elements into human proteases.

Education

Hardy received her B.S. and M.S. from Utah State University in 1994, working with Professor Ann Aust on bioinorganic chemistry projects relating to protein binding of iron and asbestos.[1] She received a Ph.D. in 2000 from the University of California, Berkeley, working with Prof. Hillary C.M. Nelson on the structure of Heat Shock Transcription Factor, which plays various roles as a molecular chaperone and an immune stimulant.[2] Her postdoctoral work was undertaken at Sunesis Pharmaceuticals with National Academy of Inventors member and UCSF professor James "Jim" Wells, who told her how to invent tethering.[3]

Career

Hardy joined the University of Massachusetts in 2005. She built a research program upon the biophysics of human proteases.[4] Her research focuses especially on caspases, apoptotic proteins involved in the regulation of cell death, and with impacts in conditions such as Alzheimer's[5] and Parkinson's Disease.[6] Hardy's research group has determined allosteric regulation of caspase-6 selectively by zinc,[7] mutation-based regulation of caspase-7,[8] and lead molecules against heat shock and multiple other cysteine proteases. Purportedly for this work, she was awarded tenure in 2012, and promoted to Full Professor in 2018. [9]

Awards

References

  1. ↑ Hardy, Jeanne A.; Aust, Ann E. (January 1995). "Iron in Asbestos Chemistry and Carcinogenicity". Chemical Reviews. 95 (1): 97–118. doi:10.1021/cr00033a005. ISSN 0009-2665.
  2. ↑ "Roles of Heat Shock Proteins". Scientific American. Retrieved 2018-10-28.
  3. ↑ "Wells named a fellow of National Academy of Inventors | School of Pharmacy | UCSF". pharmacy.ucsf.edu. 18 December 2015. Retrieved 2018-10-28.
  4. ↑ "Chemist Jeanne A. Hardy to Give Talk at Brookhaven Lab on Caspases, Causative Factor in Neurodegenerative Diseases , 4/24 | BNL Newsroom". www.bnl.gov. Retrieved 2018-10-28.
  5. ↑ "Jeanne Hardy | Fulbright Scholar Program". www.cies.org. Retrieved 2018-10-28.
  6. ↑ Dagbay, Kevin B.; Hardy, Jeanne A. (2017-09-01). "Multiple proteolytic events in caspase-6 self-activation impact conformations of discrete structural regions". Proceedings of the National Academy of Sciences. 114 (38): E7977–E7986. Bibcode:2017PNAS..114E7977D. doi:10.1073/pnas.1704640114. ISSN 0027-8424. PMC 5617271. PMID 28864531.
  7. ↑ Velázquez-Delgado, Elih M.; Hardy, Jeanne A. (2012-10-19). "Zinc-mediated Allosteric Inhibition of Caspase-6". Journal of Biological Chemistry. 287 (43): 36000–36011. doi:10.1074/jbc.M112.397752. ISSN 0021-9258. PMC 3476268. PMID 22891250.
  8. ↑ Hardy, Jeanne A.; Wells, James A. (2009-07-06). "Dissecting an allosteric switch in caspase-7 using chemical and mutational probes". Journal of Biological Chemistry. 284 (38): 26063–9. doi:10.1074/jbc.M109.001826. ISSN 0021-9258. PMC 2758006. PMID 19581639.
  9. ↑ "Jeanne Hardy | Department of Chemistry | UMass Amherst". www.umass.edu. Retrieved 2018-10-28.
  10. ↑ "Mahoney Life Sciences Prize". www.cns.umass.edu. 2017-07-07. Retrieved 2018-10-28.
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