IKZF4

IKZF4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2MA7
Identifiers
Aliases	IKZF4, EOS, ZNFN1A4, IKAROS family zinc finger 4
External IDs	OMIM: 606239 MGI: 1343139 HomoloGene: 69103 GeneCards: IKZF4
Gene location (Human)
Chr.	Chromosome 12 (human)
End	56,038,435 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	128,505,227 bp
RNA expression pattern
	Top expressed in
	left adrenal gland; ; adrenal cortex; ; right adrenal gland; ; inferior ganglion of vagus nerve; ; gastrocnemius muscle; ; ventral tegmental area; ; gastric mucosa; ; left uterine tube; ; pituitary gland; ; anterior pituitary;
	Top expressed in
	secondary oocyte; ; female urethra; ; trigeminal ganglion; ; suprachiasmatic nucleus; ; supraoptic nucleus; ; yolk sac; ; ascending aorta; ; olfactory bulb; ; superior frontal gyrus; ; aortic valve;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA-binding transcription factor activity; nucleic acid binding; sequence-specific DNA binding; DNA binding; bHLH transcription factor binding; protein homodimerization activity; metal ion binding; protein heterodimerization activity; zinc ion binding; protein domain specific binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus; nucleoplasm; nuclear body; protein-containing complex;
Biological process	negative regulation of transcription, DNA-templated; regulation of transcription, DNA-templated; transcription, DNA-templated; positive regulation of transcription by RNA polymerase II; protein homooligomerization; protein heterooligomerization;
	Sources:Amigo / QuickGO
Orthologs
	64375
	22781
	ENSG00000123411
	ENSMUSG00000002578
	Q9H2S9
	Q8C208
	NM_022465; NM_001351089; NM_001351090; NM_001351091; NM_001351092
	NM_011772; NM_001358536; NM_001358537
	NP_071910; NP_001338018; NP_001338019; NP_001338020; NP_001338021
	NP_035902; NP_001345465; NP_001345466
	Wikidata
View/Edit Human	View/Edit Mouse

Zinc finger protein Eos is a protein that in humans is encoded by the IKZF4 gene.^[5]^[6]

Members of the Ikaros (ZNFN1A1; MIM 603023) family of transcription factors, which includes Eos, are expressed in lymphocytes and are implicated in the control of lymphoid development.[supplied by OMIM]^[6]

Interactions

IKZF4 has been shown to interact with CTBP1^[7] and IKZF1.^[5]^[8]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000123411 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000002578 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 Perdomo J, Holmes M, Chong B, Crossley M (Jan 2001). "Eos and pegasus, two members of the Ikaros family of proteins with distinct DNA binding activities". J Biol Chem. 275 (49): 38347–54. doi:10.1074/jbc.M005457200. PMID 10978333.
1 2 "Entrez Gene: IKZF4 IKAROS family zinc finger 4 (Eos)".
↑ Perdomo, José; Crossley Merlin (Dec 2002). "The Ikaros family protein Eos associates with C-terminal-binding protein corepressors". Eur. J. Biochem. Germany. 269 (23): 5885–92. doi:10.1046/j.1432-1033.2002.03313.x. ISSN 0014-2956. PMID 12444977.
↑ Honma, Y; Kiyosawa H; Mori T; Oguri A; Nikaido T; Kanazawa K; Tojo M; Takeda J; Tanno Y; Yokoya S; Kawabata I; Ikeda H; Wanaka A (Mar 1999). "Eos: a novel member of the Ikaros gene family expressed predominantly in the developing nervous system". FEBS Lett. NETHERLANDS. 447 (1): 76–80. doi:10.1016/S0014-5793(99)00265-3. ISSN 0014-5793. PMID 10218586. S2CID 28898354.

Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Bao J, Lin H, Ouyang Y, et al. (2005). "Activity-dependent transcription regulation of PSD-95 by neuregulin-1 and Eos". Nat. Neurosci. 7 (11): 1250–8. doi:10.1038/nn1342. PMID 15494726. S2CID 1964177.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Perdomo J, Crossley M (2003). "The Ikaros family protein Eos associates with C-terminal-binding protein corepressors". Eur. J. Biochem. 269 (23): 5885–92. doi:10.1046/j.1432-1033.2002.03313.x. PMID 12444977.
Koipally J, Georgopoulos K (2002). "A molecular dissection of the repression circuitry of Ikaros". J. Biol. Chem. 277 (31): 27697–705. doi:10.1074/jbc.M201694200. PMID 12015313.
Nagase T, Nakayama M, Nakajima D, et al. (2001). "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 8 (2): 85–95. doi:10.1093/dnares/8.2.85. PMID 11347906.
Honma Y, Kiyosawa H, Mori T, et al. (1999). "Eos: a novel member of the Ikaros gene family expressed predominantly in the developing nervous system". FEBS Lett. 447 (1): 76–80. doi:10.1016/S0014-5793(99)00265-3. PMID 10218586. S2CID 28898354.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000123411 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000002578 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10978333-5] 1 2 Perdomo J, Holmes M, Chong B, Crossley M (Jan 2001). "Eos and pegasus, two members of the Ikaros family of proteins with distinct DNA binding activities". J Biol Chem. 275 (49): 38347–54. doi:10.1074/jbc.M005457200. PMID 10978333.

[entrez-6] 1 2 "Entrez Gene: IKZF4 IKAROS family zinc finger 4 (Eos)".

[pmid12444977-7] Perdomo, José; Crossley Merlin (Dec 2002). "The Ikaros family protein Eos associates with C-terminal-binding protein corepressors". Eur. J. Biochem. Germany. 269 (23): 5885–92. doi:10.1046/j.1432-1033.2002.03313.x. ISSN 0014-2956. PMID 12444977.

[pmid10218586-8] Honma, Y; Kiyosawa H; Mori T; Oguri A; Nikaido T; Kanazawa K; Tojo M; Takeda J; Tanno Y; Yokoya S; Kawabata I; Ikeda H; Wanaka A (Mar 1999). "Eos: a novel member of the Ikaros gene family expressed predominantly in the developing nervous system". FEBS Lett. NETHERLANDS. 447 (1): 76–80. doi:10.1016/S0014-5793(99)00265-3. ISSN 0014-5793. PMID 10218586. S2CID 28898354.

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Interactions

References

Further reading