Hubert Schoemaker
Born(1950-03-23)March 23, 1950
Deventer, Netherlands
DiedJanuary 1, 2006(2006-01-01) (aged 55)
Paoli, Pennsylvania)
NationalityDutch
CitizenshipDutch
Alma materUniversity of Notre Dame
Massachusetts Institute of Technology
Known forRemicade
SpouseAnn Postorino (1) Anne Faulkner Schoemaker (2)[1]
ChildrenMaureen, Katherine, Anne, and Hubert Matthew Schoemaker)
Scientific career
Fieldsimmunology, biochemistry, business, biotechnology
InstitutionsCentocor
Corning
Neuronyx

Hubert Jacob Paul Schoemaker (March 23, 1950 – January 1, 2006)[2] was a Dutch biotechnologist. He was a co-founder and the president of one of America's first biotechnology companies, Centocor, which was founded in 1979 for the commercialising of monoclonal antibodies. In 1999 he founded Neuronyx, Inc., for the manufacture of stem cells and the development of stem-cell therapies.[3]

Early life and education

Schoemaker was born in Deventer, Netherlands. He attended St. Bernardus School in Deventer, and Canisius College, Nijmegen. In 1969 he moved to the United States to attend the University of Notre Dame, where he majored in chemistry, graduating in May 1972. Soon after he married Ann Postorino.[4]

He then earned a doctorate in biochemistry in 1975 from the Massachusetts Institute of Technology. Supervised by Paul Schimmel, his doctoral research was an investigation of the structure function relationships of transfer RNAs and their complexes.[4]

Career

After declining postdoctoral research positions with Stanley Cohen and Klaus Weber, Schoemaker chose to work as a research scientist in industry. His choice was influenced by the severe disabilities suffered by his first daughter, Maureen, who was born with lissencephaly and needed specialised care. This inspired Schoemaker to become involved in commercial biotechnology.[1]

In 1976 Schoemaker joined Corning Medical, a Boston-based division of Corning Glass Works. At Corning Schoemaker rapidly progressed from being a specialist in immunoassay development for diagnostics to heading research and development. Among his achievements at the company was devising effective diagnostic kit tests for thyroid disorders.[1]

In 1979 Schoemaker became involved in the founding of Centocor together with a former Corning Medical colleague Ted Allen and the bioentrepreneur Michael Wall with whom he had some dealings while at Corning.[1] Inspired by the work of Hilary Koprowski, who developed some of the earliest monoclonal antibodies against tumour antigens and influenza viral antigens, the objective of Centocor was to commercialise monoclonal antibodies for diagnostics and therapeutics.[5] In 1980 Schoemaker joined Centocor and soon after became its first chief executive officer.[1]

From the start Centocor decided to fill its product pipeline through partnerships with research institutions and marketing alliances. Central to this policy was Schoemaker's ability to network and the company's decision to design diagnostic kits so that were compatible with existing diagnostic systems. Under Schoemaker's leadership Centocor rapidly grew into a profitable diagnostic business. By 1985 the company had revenues of approximately $50 million. In part this success was built upon the swift approval the company won for two of its tests. The first was for gastrointestinal cancer test and the other was for hepatitis B. Between 1983 and 1986 Centocor introduced three other diagnostic tests to the market: one for ovarian cancer (the first diagnostic test available for the disease), one for breast cancer and one for colorectal cancer.[6]

Despite the company's success on the diagnostic front, Schoemaker was plunged in 1992 into efforts to save the company from bankruptcy when its first therapeutic, Centoxin, a drug designed to treat septic shock, failed to win FDA approval.[7] In part the crisis had come about as a result of the company's executives trying to go it alone in developing the drug. What saved the company was a return to the policy of collaboration. Learning from its mistakes with Centoxin, in December 1994 Centocor gained marketing approval for ReoPro, a monoclonal antibody drug for cardiovascular disease. The first therapeutic to ever receive simultaneous US and European approvals, and the second monoclonal antibody to ever win approval as a drug, ReoPro marked a milestone for both Centocor and for monoclonal antibodies therapeutics. ReoPro was to be followed in August 1998 by the approval of Centocor's Remicade, a drug to treat auto-immune disorders like Crohn's disease and rheumatoid arthritis.[8]

After selling Centocor to Johnson and Johnson in 1999, Schoemaker went on to form Neuronyx, Inc., a biotech company focused on developing cellular therapies. After Schoemaker died in 2006 the company was continued by his wife Anne Faulkner Schoemaker. Initial work focused on using stem cells taken from adult bone marrow to help regenerate heart tissue damaged during heart attacks.[9] Later the company turned direction to looking at the development of a treatment for incision wounds in women following breast cancer reconstruction surgery. The company later changed its name to Garnet BioTherapeutics.[10] Despite promising clinical results and raising more than $55 million in venture capital funding, the company was unable to continue.[11]

Death

Schoemaker was diagnosed in 1994 with a form of brain cancer, medulloblastoma.[1] He died on January 1, 2006, at age 55.[2]

References

  1. 1 2 3 4 5 6 "Dr. Hubert Schoemaker". What is Biotechnology?. Retrieved 9 November 2018.
  2. 1 2 Pollack, Andrew (January 13, 2006). "Hubert Schoemaker, a Biotech Pioneer, Dies at 55". The New York Times.
  3. ↑ Center for Oral History. "Hubert J.P. Schoemaker". Science History Institute.
  4. 1 2 Marks, Lara; Everson, Ted; Dionisio, Jen, eds. (9 July 1997). The Life of Hubert J. P. Schoemaker (1950–2006) An Oral History (PDF). Philadelphia, PA: Chemical Heritage Foundation.
  5. ↑ "Professor Hilary Koprowski". What is Biotechnology?. Retrieved 9 November 2018.
  6. ↑ Marks, L.V. (2009) "Collaboration - a competitor's tool: The story of Centocor, an entrepreneurial biotechnology company", Business History, 51(4): 529-46.
  7. ↑ Dionisio, Jennifer (2008). "A Will and a Way". Chemical Heritage Magazine. Chemical Heritage Foundation. Retrieved November 8, 2018.
  8. ↑ Marks, L. (2012) "The birth pangs of monoclonal antibody therapeutics", mAbs, 4 (3), 1-10.
  9. ↑ MORAN, SARAH E. (March 2, 2007). "Reducing tissue damage after a heart attack". Daily Local News. Retrieved 9 November 2018.
  10. ↑ "Company Overview of Garnet Biotherapeutics, Inc". Bloomberg. Retrieved 9 November 2018.
  11. ↑ "Venture-Backed Garnet BioTherapeutics, Inc. Files for Chapter 11 Bankruptcy". Seeking Alpha. December 30, 2010. Retrieved 9 November 2018.
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