HLA-A74
(MHC Class I, A cell surface antigen)
HLA-A74
About
Proteintransmembrane receptor/ligand
Structureαβ heterodimer
SubunitsHLA-A*74--, β2-microglobulin
Subtypes
Subtype
allele
Available structures
A74 *7401
{{{cNick2}}} *74{{{cAllele2}}}
{{{cNick3}}} *74{{{cAllele3}}}
{{{cNick4}}} *74{{{cAllele4}}}
Rare alleles
Subtype
allele
Available structures
A74.3 *7403
{{{rnick2}}} *74{{{rallele2}}}
{{{rnick3}}} *74{{{rallele3}}}
Alleles link-out to IMGT/HLA database at EBI

HLA-A74 (A74) is a human leukocyte antigen serotype within HLA-A serotype group. The serotype is determined by the antibody recognition of α74 subset of HLA-A α-chains. For A74, the alpha "A" chain are encoded by the HLA-A*74 allele group and the β-chain are encoded by B2M locus.[1] A74 and A*74 are almost synonymous in meaning. A74 is a split antigen of the broad antigen serotype A19. A74 is a sister serotype of A29, A30, A31, A32, and A33.

Further information: History and naming of human leukocyte antigens

A74 is more common in Subsaharan Africa. A74 is a rare HLA-A allele group.

Serotype

A74 recognition of some HLA A*74 gene products[2]
A*74 A74 A19 Sample
allele % % size (N)
*74014011119
*740317029

A74 has a poor serotyping rate.

Disease associations

A significant association has been found between A74 and nasal polyposis.[3]

Allele distribution

HLA A*7401 frequencies
Study populationFreq.
 (in %)[4]
Colombia African Black11.6
Kenya9.4
Cameroon Beti8.3
Guinea Bissau7.7
Kenya Luo7.2
Burkina Faso Mossi6.6
South African Natal Zulu6.5
Cape Verde Southeastern I…5.6
Uganda Kampala5.2
Cameroon Yaounde5.0
Cameroon Bamileke4.5
USA African America4.0
Cameroon Sawa3.8
South Africa Tswana3.7
Mali Bandiagara3.6
Iran Baloch2.8
Zimbabwe Harare Shona2.7
Zambia Lusaka2.3
Senegal Niokholo Mandenka2.2
Burkina Faso Rimaibe2.1
Tunisia Ghannouch1.8
Kenya Nandi1.7
Brazil Parana Mulatto1.6
Brazil1.5
Morocco Nador Metalsa Cla…1.4
Thailand Northeast1.2
Venezuela Colonia Tovar1.2
Brazil Belo Horizonte1.1
Thailand1.1
Tunisia Tunis1.1
Turkey (1)1.1
Allele frequencies presented, only
HLA A*7403 frequencies
Study populationFreq.
 (in %)[4]
Kenya Luo2.8
Argentina Toba Rosario0.6
Iran Baloch0.6
Saudi Arabia Guraiat and …0.5
Kenya0.3
Madeira0.3
Uganda Kampala0.3
Allele frequencies presented, only

Sources

  • Madrigal JA, Belich MP, Hildebrand WH, et al. (November 1992). "Distinctive HLA-A,B antigens of black populations formed by interallelic conversion" (PDF). J. Immunol. 149 (10): 3411–5. PMID 1431115.

References

  1. ↑ Arce-Gomez B, Jones EA, Barnstable CJ, Solomon E, Bodmer WF (February 1978). "The genetic control of HLA-A and B antigens in somatic cell hybrids: requirement for beta2 microglobulin". Tissue Antigens. 11 (2): 96–112. doi:10.1111/j.1399-0039.1978.tb01233.x. PMID 77067.
  2. ↑ Allele Query Form IMGT/HLA - European Bioinformatics Institute
  3. ↑ Luxenberger W, Posch U, Berghold A, Hofmann T, Lang-Loidolt D (2000). "HLA patterns in patients with nasal polyposis". European Archives of Oto-Rhino-Laryngology. 257 (3): 137–9. doi:10.1007/s004050050210. PMID 10839486.
  4. 1 2 Middleton, D.; Menchaca, L.; Rood, H.; Komerofsky, R. (2003). "New allele frequency database: http://www.allelefrequencies.net". Tissue Antigens. 61 (5): 403–407. doi:10.1034/j.1399-0039.2003.00062.x. PMID 12753660.
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