Response elements are short sequences of DNA within a gene promoter or enhancer region that are able to bind specific transcription factors and regulate transcription of genes.

Under conditions of stress, a transcription activator protein binds to the response element and stimulates transcription. If the same response element sequence is located in the control regions of different genes, then these genes will be activated by the same stimuli, thus producing a coordinated response.

Hormone response element

A hormone response element (HRE) is a short sequence of DNA within the promoter of a gene, that is able to bind to a specific hormone receptor complex and therefore regulate transcription.[1] The sequence is most commonly a pair of inverted repeats separated by three nucleotides, which also indicates that the receptor binds as a dimer. Specifically, HRE responds to steroid hormones, as the activated steroid receptor is the transcription factor binding HRE. This regulates the transcription of genes signalled by the steroid hormone.

A gene may have many different response elements, allowing complex control to be exerted over the level and rate of transcription.[2]

HRE are used in transgenic animal cells as inducers of gene expression.

Examples of HREs include estrogen response elements and androgen response elements.

Examples

Examples of response elements include:

References

  1. 1 2 Kimball JW (25 April 2011). "Steroid Hormone Receptors and their Response Elements". Kimball's Biology Pages.
  2. ↑ Krieger M, Scott MP, Matsudaira PT, Lodish HF, Darnell JE, Lawrence Z, Kaiser C, Berk A (2003). Molecular Cell Biology (Fifth ed.). San Francisco: W.H. Freeman. p. 973 pages. ISBN 0-7167-4366-3.
  3. ↑ Penvose, A; Keenan, JL; Bray, D; Ramlall, V; Siggers, T (7 June 2019). "Comprehensive study of nuclear receptor DNA binding provides a revised framework for understanding receptor specificity". Nature Communications. 10 (1): 2514. Bibcode:2019NatCo..10.2514P. doi:10.1038/s41467-019-10264-3. PMC 6555819. PMID 31175293.


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.