GKN1

GKN1
Identifiers
Aliases	GKN1, AMP18, BRICD1, CA11, FOV, foveolin, gastrokine 1
External IDs	OMIM: 606402 MGI: 1913533 HomoloGene: 10487 GeneCards: GKN1
Gene location (Human)
Chr.	Chromosome 2 (human)
End	68,980,980 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	87,327,924 bp
RNA expression pattern
	Top expressed in
	gastric mucosa; ; pylorus; ; cardia; ; body of stomach; ; fundus; ; left adrenal gland; ; pancreatic ductal cell; ; left uterine tube; ; right lung; ; canal of the cervix;
	Top expressed in
	epithelium of stomach; ; mucous cell of stomach; ; pyloric antrum; ; duodenum; ; interventricular septum; ; esophagus; ; cornea; ; jejunum; ; islet of Langerhans; ; sexually immature organism;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	molecular function;
Cellular component	extracellular region; extracellular space; cellular component;
Biological process	digestion; positive regulation of cell division; regulation of cell population proliferation;
	Sources:Amigo / QuickGO
Orthologs
	56287
	66283
	ENSG00000169605
	ENSMUSG00000030050
	Q9NS71
	Q9CR36
	NM_019617
	NM_025466
	NP_062563
	NP_079742
	Wikidata
View/Edit Human	View/Edit Mouse

Gastrokine-1 is a protein that in humans is encoded by the GKN1 gene.^[5]^[6]^[7]

The protein encoded by this gene is found to be down-regulated in human gastric cancer tissue as compared to normal gastric mucosa.^[7]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000169605 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030050 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Martin TE, Powell CT, Wang Z, Bhattacharyya S, Walsh-Reitz MM, Agarwal K, Toback FG (August 2003). "A novel mitogenic protein that is highly expressed in cells of the gastric antrum mucosa" (PDF). American Journal of Physiology. Gastrointestinal and Liver Physiology. 285 (2): G332-43. doi:10.1152/ajpgi.00453.2002. PMID 12851218. S2CID 2860022. Archived from the original (PDF) on 2019-03-02.
↑ Shiozaki K, Nakamori S, Tsujie M, Okami J, Yamamoto H, Nagano H, et al. (October 2001). "Human stomach-specific gene, CA11, is down-regulated in gastric cancer". International Journal of Oncology. 19 (4): 701–7. doi:10.3892/ijo.19.4.701. PMID 11562744.
1 2 "Entrez Gene: GKN1 gastrokine 1".

Yoshikawa Y, Mukai H, Hino F, Asada K, Kato I (May 2000). "Isolation of two novel genes, down-regulated in gastric cancer". Japanese Journal of Cancer Research. 91 (5): 459–63. doi:10.1111/j.1349-7006.2000.tb00967.x. PMC 5926377. PMID 10835488.
Westley BR, Griffin SM, May FE (June 2005). "Interaction between TFF1, a gastric tumor suppressor trefoil protein, and TFIZ1, a brichos domain-containing protein with homology to SP-C". Biochemistry. 44 (22): 7967–75. doi:10.1021/bi047287n. PMID 15924415.
Walsh-Reitz MM, Huang EF, Musch MW, Chang EB, Martin TE, Kartha S, Toback FG (July 2005). "AMP-18 protects barrier function of colonic epithelial cells: role of tight junction proteins". American Journal of Physiology. Gastrointestinal and Liver Physiology. 289 (1): G163-71. doi:10.1152/ajpgi.00013.2005. PMC 1444946. PMID 15961882.
Nardone G, Rippa E, Martin G, Rocco A, Siciliano RA, Fiengo A, et al. (February 2007). "Gastrokine 1 expression in patients with and without Helicobacter pylori infection". Digestive and Liver Disease. 39 (2): 122–9. doi:10.1016/j.dld.2006.09.017. PMID 17092786.

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