GEFT

ARHGEF25
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2RGN
Identifiers
Aliases	ARHGEF25, GEFT, p63RhoGEF, Rho guanine nucleotide exchange factor 25
External IDs	OMIM: 610215 MGI: 1277173 HomoloGene: 32691 GeneCards: ARHGEF25
Gene location (Human)
Chr.	Chromosome 12 (human)
End	57,617,245 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	127,025,952 bp
RNA expression pattern
	Top expressed in
	right coronary artery; ; gastric mucosa; ; popliteal artery; ; left uterine tube; ; myometrium; ; thoracic aorta; ; ascending aorta; ; left coronary artery; ; superior frontal gyrus; ; smooth muscle tissue;
	Top expressed in
	hippocampus proper; ; primary motor cortex; ; superior frontal gyrus; ; vas deferens; ; Region I of hippocampus proper; ; belly cord; ; prefrontal cortex; ; piriform cortex; ; internal carotid artery; ; external carotid artery;
	More reference expression data
	n/a
Gene ontology
Molecular function	guanyl-nucleotide exchange factor activity;
Cellular component	cytoplasm; cytosol; plasma membrane; myofibril; sarcomere; membrane;
Biological process	regulation of Rho protein signal transduction; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	115557
	52666
	ENSG00000240771
	ENSMUSG00000019467
	Q86VW2
	Q9CWR0
	NM_001111270; NM_133483; NM_182947; NM_001347933
	NM_001166413; NM_028027; NM_001358557; NM_001358558
	NP_001104740; NP_891992; NP_001334862
	NP_001159885; NP_082303; NP_001345486; NP_001345487
	Wikidata
View/Edit Human	View/Edit Mouse

RAC/CDC42 exchange factor, also known as GEFT, is a human gene.^[5]

Interactions

GEFT has been shown to interact with RHOA.^[6]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000240771 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000019467 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: GEFT RAC/CDC42 exchange factor".
↑ Lutz S, Freichel-Blomquist A, Rümenapp U, Schmidt M, Jakobs KH, Wieland T (May 2004). "p63RhoGEF and GEFT are Rho-specific guanine nucleotide exchange factors encoded by the same gene". Naunyn Schmiedebergs Arch. Pharmacol. 369 (5): 540–6. doi:10.1007/s00210-004-0926-5. PMID 15069594. S2CID 19812449.

Lutz S, Shankaranarayanan A, Coco C, Ridilla M, Nance MR, Vettel C, Baltus D, Evelyn CR, Neubig RR, Wieland T, Tesmer JJ (2008). "Structure of Galphaq-p63RhoGEF-RhoA complex reveals a pathway for the activation of RhoA by GPCRs". Science. 318 (5858): 1923–7. doi:10.1126/science.1147554. PMID 18096806. S2CID 2418867.
Bryan BA, Cai Y, Liu M (2006). "The Rho-family guanine nucleotide exchange factor GEFT enhances retinoic acid- and cAMP-induced neurite outgrowth". J. Neurosci. Res. 83 (7): 1151–9. doi:10.1002/jnr.20814. PMID 16496360. S2CID 11130365.
Bryan BA, Mitchell DC, Zhao L, Ma W, Stafford LJ, Teng BB, Liu M (2006). "Modulation of muscle regeneration, myogenesis, and adipogenesis by the Rho family guanine nucleotide exchange factor GEFT". Mol. Cell. Biol. 25 (24): 11089–101. doi:10.1128/MCB.25.24.11089-11101.2005. PMC 1316953. PMID 16314529.
Lutz S, Freichel-Blomquist A, Yang Y, Rümenapp U, Jakobs KH, Schmidt M, Wieland T (2005). "The guanine nucleotide exchange factor p63RhoGEF, a specific link between Gq/11-coupled receptor signaling and RhoA". J. Biol. Chem. 280 (12): 11134–9. doi:10.1074/jbc.M411322200. PMID 15632174.
Bryan B, Kumar V, Stafford LJ, Cai Y, Wu G, Liu M (2004). "GEFT, a Rho family guanine nucleotide exchange factor, regulates neurite outgrowth and dendritic spine formation". J. Biol. Chem. 279 (44): 45824–32. doi:10.1074/jbc.M406216200. PMID 15322108.
Lutz S, Freichel-Blomquist A, Rümenapp U, Schmidt M, Jakobs KH, Wieland T (2004). "p63RhoGEF and GEFT are Rho-specific guanine nucleotide exchange factors encoded by the same gene". Naunyn Schmiedebergs Arch. Pharmacol. 369 (5): 540–6. doi:10.1007/s00210-004-0926-5. PMID 15069594. S2CID 19812449.
Guo X, Stafford LJ, Bryan B, Xia C, Ma W, Wu X, Liu D, Songyang Z, Liu M (2003). "A Rac/Cdc42-specific exchange factor, GEFT, induces cell proliferation, transformation, and migration". J. Biol. Chem. 278 (15): 13207–15. doi:10.1074/jbc.M208896200. PMID 12547822.
Souchet M, Portales-Casamar E, Mazurais D, Schmidt S, Léger I, Javré JL, Robert P, Berrebi-Bertrand I, Bril A, Gout B, Debant A, Calmels TP (2002). "Human p63RhoGEF, a novel RhoA-specific guanine nucleotide exchange factor, is localized in cardiac sarcomere". J. Cell Sci. 115 (Pt 3): 629–40. doi:10.1242/jcs.115.3.629. PMID 11861769.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000240771 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000019467 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: GEFT RAC/CDC42 exchange factor".

[pmid15069594-6] Lutz S, Freichel-Blomquist A, Rümenapp U, Schmidt M, Jakobs KH, Wieland T (May 2004). "p63RhoGEF and GEFT are Rho-specific guanine nucleotide exchange factors encoded by the same gene". Naunyn Schmiedebergs Arch. Pharmacol. 369 (5): 540–6. doi:10.1007/s00210-004-0926-5. PMID 15069594. S2CID 19812449.

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Interactions

References

Further reading