Evolution of Infectious Disease
AuthorPaul W. Ewald
LanguageEnglish
SubjectEvolutionary biology
PublisherOxford University Press
Publication date
December 1, 1993
Pages320
ISBN0-19-506058-X
OCLC27221612
616.9/0471 20
LC ClassRC112 .E93 1994

Evolution of Infectious Disease is a 1993 book by the evolutionary biologist Paul W. Ewald. In this book, Ewald contests the traditional view that parasites should evolve toward benign coexistence with their hosts. He draws on various studies that contradict this dogma and asserts his theory based on fundamental evolutionary principles. This book provides one of the first in-depth presentations of insights from evolutionary biology on various fields in health science, including epidemiology and medicine.

Infectious diseases

Infectious disease are illnesses induced by another organism.[1] Such diseases range from mild to severe cases. The onset of infectious disease can be induced by bacteria, viruses, fungi, and parasites.[1] Several examples of infectious diseases are as follows: tuberculosis, chickenpox, mumps, meningitis, measles, and malaria.[2] Infectious diseases can be obtained through many routes of transmission such as inhalation, open wounds, sores, ingestion, sexual intercourse, and insect bites.[3] Author, Paul Ewald used his book to expound upon infectious diseases in humans and animals, explain various routes of transmission as well as epidemiology as a whole.[1] Epidemiology is defined as the study of the onset, distribution, and control of diseases.[4] Evolutionary epidemiology focuses on the distribution of infectious diseases whereas Darwinian epidemiology focuses on human beings as hosts of infectious diseases.[1] To fully comprehend both aspects of epidemiology, it is necessary to understand how organisms induce these diseases as well as how infected organisms counteract.

Evolution

The extensive research about pathogens shows that they can evolve within a month, whereas animal hosts such as humans take centuries to make large evolutionary changes.[5] Parasite virulence and host resistance are variables that strongly impact a pathogen's ability to replicate and be distributed to many hosts. Parasite virulence is the level of harm a host endures due to a virus, bacteria, or parasite.[1] The way a host lives contributes heavily to how their body will react to pathogens. If an organism lives a moderately healthy lifestyle, including its diet, physical activity, and decreased stress, its chances of fighting off infectious diseases increase.

Host resistance pivots around how well a host's immune system can fight off a disease and rid their body of the pathogens.[6] Although a healthy lifestyle can help a host, infectious diseases seem to evolve so quickly that a new generation of a disease may have emerged before scientists have the chance to make a vaccination for the first generation. Pathogens adapt to the medications and form a resistance to them which causes the new generations of pathogens to be more detrimental than the previous generations.[7] After many generations have emerged, scientists must continuously form new vaccinations to combat the components of the disease that evolve every time a generation appears.

Experimental data

Two sets of experiments were performed which tested the correlation of pathogens and declining organism populations as well as zoonotic pathogens being associated with emerging infectious diseases. The first experiment focused solely on a pathogen's ability to decrease or completely wipe out a whole population of organisms. In this experiment, researchers used Daphnia magna as the host and six microparasites were vertically transmitted to the host.[8] Researchers Ebert, Lipsitch, and Mangin found that while pathogens and parasites do cause a change in a population, they do not have the ability to destroy an entire population.[7] The pathogens did however have an impact on the host's fertility. Some females involved in the experiment were unable to reproduce after being infected with the microparasites.[9]

The second experiment focused more on zoonotic pathogens being correlated with emerging infectious diseases in humans. The researchers comprised a database with separate infectious species, infectious pathogens that cause disease in patients with abnormal immune systems, and pathogens that have only been found in one case of human disease.[10] The researchers broke this database down into five portions which were viruses, bacteria, fungi, protozoa, and helminths. Direct contact, indirect contact, and vector borne were the routes of transmission used.[11] They found that 1415 zoonotic pathogen diseases have been found in humans.

See also


References

  1. 1 2 3 4 5 Ewald, Paul (2010). Evolution of Infectious Disease. Oxford: Oxford university press. pp. 1–50.
  2. ↑ Wilson, M (1995). "Travel and the emergence of infectious diseases". Ann. N.Y. Acad. Sci. 740: 1–500. doi:10.1111/j.1749-6632.1994.tb19849.x. PMID 7840439. S2CID 6467348.
  3. ↑ Krilov, L (2018). "Infectious Disease Update". Pediatric Annals. 47 (9): e345–e346. doi:10.3928/19382359-20180809-02. PMID 30208192.
  4. ↑ Leventhal, Gabriel E.; Hill, Alison L.; Nowak, Martin A.; Bonhoeffer, Sebastian (2015). "Evolution and emergence of infectious diseases in theoretical and real-world networks". Nature Communications. 6: 6. Bibcode:2015NatCo...6.6101L. doi:10.1038/ncomms7101. PMC 4335509. PMID 25592476.
  5. ↑ Schrag, S. J.; Wiener, P. (1995). "Emerging infectious disease: What are the relative roles of ecology and evolution?". Trends in Ecology and Evolution. 10 (8): 319–324. doi:10.1016/S0169-5347(00)89118-1. PMID 21237055.
  6. ↑ Zwizwai, R. (2018). "Infectious disease surveillance update". Lancet Infectious Diseases. 18 (9): 9. doi:10.1016/S1473-3099(18)30507-3. S2CID 206157175.
  7. 1 2 Woolhouse, M. E. J.; Taylor, Louise H.; Haydon, Daniel T. (2001). "Population biology of multi-host pathogens". Science. 292 (5519): 1109–112. Bibcode:2001Sci...292.1109W. doi:10.1126/science.1059026. PMID 11352066. S2CID 40290820.
  8. ↑ Ebert, Dieter; Lipsitch, Marc; Mangin, Katrina L. (2000). "The Effect of Parasites on Host Population Density and Extinction: Experimental Epidemiology with Daphnia and Six Microparasites". The American Naturalist. 156 (5): 459–477. doi:10.1086/303404. PMID 29587512. S2CID 4406535.
  9. ↑ Bengtsson, Jan; Milbrink, Göran (1995). "Predicting extinctions: interspecific competition, predation and population variability in experimental Daphnia populations". Oecologia. 101 (4): 397–406. Bibcode:1995Oecol.101..397B. doi:10.1007/BF00329418. PMID 28306954. S2CID 12286690.
  10. ↑ Taylor, Louise H.; Latham, Sophia M.; Woolhouse, Mark E.J. (2001). "Risk factors for human disease emergence". Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences. 356 (1411): 983–989. doi:10.1098/rstb.2001.0888. PMC 1088493. PMID 11516376.
  11. ↑ Úbeda, Francisco; Jansen, Vincent A. A. (2016). "The evolution of sex-specific virulence in infectious diseases". Nature Communications. 7: 13849. Bibcode:2016NatCo...713849U. doi:10.1038/ncomms13849. PMC 5159935. PMID 27959327.
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